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Anti-β2-glycoprotein I in Sjogren’s syndrome is associated with parkinsonism

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Abstract

The nervous system may be involved in up to 30% of patients with Sjogren’s syndrome (SS). We describe three patients with Sjogren’s syndrome and a concomitant parkinsonian syndrome. Elevated titers of anti-β2-glycoprotein I IgG were found in the serum of all three patients. This autoantibody is strongly associated with anticardiolipin (aCL) antibodies, antiphospholipid syndrome (APS), and thromboembolic phenomena, but its role in the pathogenesis of the parkinsonian disorder in SS is unclear. These patients may present a subtype of SS patients in which the presence of aCL antibodies is associated with central nervous system involvement predominantly in the basal ganglia.

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Authors and Affiliations

  1. Department of Neurology, Sackler Faculty of Medicine, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, 52621, Tel-Aviv, Israel

    Sharon Hassin-Baer

  2. Department of Medicine E, Sackler Faculty of Medicine, Meir Medical Center, Tel Aviv University, KFAR SABA, 44281, Tel Aviv, Israel

    Yair Levy

  3. Department of Internal Medicine F, Sackler Faculty of Medicine, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, 52621, Tel Aviv, Israel

    Pnina Langevitz

  4. Department of Family Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Sasson Nakar

  5. Department of Internal Medicine C, Sackler Faculty of Medicine, Chaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, 52621, Tel Aviv, Israel

    Michael Ehrenfeld

Authors
  1. Sharon Hassin-Baer
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  2. Yair Levy
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  3. Pnina Langevitz
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  4. Sasson Nakar
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  5. Michael Ehrenfeld
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Corresponding author

Correspondence to Yair Levy.

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Sharon Hassin-Baer and Levy Yair contributed equally to this work.

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Hassin-Baer, S., Levy, Y., Langevitz, P. et al. Anti-β2-glycoprotein I in Sjogren’s syndrome is associated with parkinsonism. Clin Rheumatol 26, 743–747 (2007). https://doi.org/10.1007/s10067-006-0398-8

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  • DOI: https://doi.org/10.1007/s10067-006-0398-8

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