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Inverse relationship between multiple sclerosis and allergic respiratory diseases

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Abstract

Th1 up-regulation seems to favour autoimmunity, while Th2 up-regulation seems to favour humoral immunity. Accordingly, subjects affected by atopic diseases (such as allergic respiratory diseases, ARDs) should be less prone to autoimmune diseases (such as multiple sclerosis, MS), and vice versa. The recent identification of Th17 cells, which seem to favour the development of both autoimmunity and allergy, led to the revision of the classic Th1/Th2 paradigm. We studied 200 MS patients and 200 controls to analyze the relationships between ARDs and MS. MS patients had less probability to suffer from ARDs (OR = 0.30, p < 0.001) and allergic rhinitis (OR = 0.25, p < 0.001), after adjusting for environmental factors. MS tended to be less severe when associated to ARDs. Our findings add some elements for the comprehension of immune mechanisms involved in MS pathogenesis and suggest to analyze other MS cohorts, in order to evaluate if MS patients affected by allergic diseases show particular clinical findings.

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References

  1. Rudwaleit M, Andermann B, Alten R et al (2002) Atopic disorders in ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis 61:968–974

    Article  PubMed  CAS  Google Scholar 

  2. Provenzano G, Donato G, Brai G, Rinaldi F (2002) Prevalence of allergic respiratory diseases in patients with RA. Ann Rheum Dis 61:281

    Article  PubMed  CAS  Google Scholar 

  3. Edwards LJ, Constantinescu CS (2004) A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult Scler 10:575–581

    Article  PubMed  CAS  Google Scholar 

  4. Neukirch F, Lyon-Caen O, Clanet M, Bosquet J, Feingold J, Duret P (1997) Asthma, nasal allergies and multiple sclerosis. J Allergy Clin Immunol 99:270–271

    PubMed  CAS  Google Scholar 

  5. Tremlett HL, Evans J, Wiles CM, Luscombe DK (2002) Asthma and multiple sclerosis: an inverse association in a case–control general practice population. Q J Med 95:753–756

    CAS  Google Scholar 

  6. Solaro C, Messmer Uccelli M, Guglieri P et al (2002) Prevalence of atopy in multiple sclerosis patients: a case–control study. J Neurol 248:239–240

    Google Scholar 

  7. Alonso A, Hernán MA, Ascherio A (2008) Allergy, family history of autoimmune diseases, and the risk of multiple sclerosis. Acta Neurol Scand 117:15–20

    PubMed  CAS  Google Scholar 

  8. McDonald WI, Compson A, Edan G et al (2001) Recommended diagnostic criteria for multiple sclerosis guidelines from the international panel on the diagnosis of MS. Ann Neurol 50:121–127

    Article  PubMed  CAS  Google Scholar 

  9. European Community Respiratory Health Group (2002) The European respiratory health survey II. Eur Respir J 20:1071–1079

    Article  Google Scholar 

  10. European Community Respiratory Health Group (1996) Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 9:87–695

    Google Scholar 

  11. Wjst M, Dharmage S, André E et al (2005) Latitude, birth date, and allergy. PLoS Med 2:e294

    Article  PubMed  Google Scholar 

  12. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452

    PubMed  CAS  Google Scholar 

  13. Roxburgh RH, Seaman SR, Masterman T et al (2005) Multiple sclerosis severity score: using disability and disease duration to rate disease severity. Neurology 64:1144–1151

    PubMed  CAS  Google Scholar 

  14. Miranda C, Busacker A, Balzar S, Trudeau J, Wenzel SE (2004) Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 113:101–108

    Article  PubMed  Google Scholar 

  15. Kidd P (2003) Th1/Th2 balance: the hypothesis, its limitations, and implications for health anddisease. Altern Med Rev 8:223–246

    PubMed  Google Scholar 

  16. Pedotti R, De Voss JJ, Steinman L, Galli SJ (2003) Involvement of both ‘allergic’ and ‘autoimmune’ mechanisms in EAE, MS and other autoimmune diseases. Trends Immunol 24:479–484

    Article  PubMed  CAS  Google Scholar 

  17. Harrington LE, Hatton RD, Mangan PR et al (2005) Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper 1 and 2 lineages. Nat Immunol 6:1123–1132

    Article  PubMed  CAS  Google Scholar 

  18. Oboki K, Ohno T, Saito H, Nakae S (2008) Th17 and allergy. Allergol Int 57:121–134

    Article  PubMed  CAS  Google Scholar 

  19. Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008) Th17 in human disease. Immunol Rev 223:87–113

    Article  PubMed  CAS  Google Scholar 

  20. Molet S, Hamid Q, Davoine F et al (2001) Il-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 108:430–438

    Article  PubMed  CAS  Google Scholar 

  21. Klemens C, Rasp G, Jund F et al (2007) Mediators and cytokine in allergic and viral-induced rhinitis. Allergy Asthma Proc 28:434–441

    Article  PubMed  CAS  Google Scholar 

  22. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG (2002) Multiple sclerosis. N Engl J Med 343:938–952

    Article  Google Scholar 

  23. Al-Shammri S, Rawoot P, Azizieh F et al (2004) Th1/Th2 cytokine patterns and clinical profiles during and after pregnancy in women with multiple sclerosis. J Neurol Sci 222:21–27

    Article  PubMed  CAS  Google Scholar 

  24. Arnon R, Aharoni R (2004) Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications. Proc Natl Acad Sci USA 101(Suppl 2):14593–14598

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Neurology, Multiple Sclerosis Centre, CRISM, Neurological Institute ‘C. Mondino’, Via Mondino 2, 27100, Pavia, Italy

    Roberto Bergamaschi, Massimo Crabbio, Alfredo Romani, Valeria Bargiggia & Vittorio Cosi

  2. Department of Health Sciences, Statistics and Epidemiology Unit, University of Pavia, Pavia, Italy

    Simona Villani, Michela Ponzio & Anna Verri

Authors
  1. Roberto Bergamaschi
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  2. Simona Villani
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  3. Massimo Crabbio
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  4. Michela Ponzio
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  5. Alfredo Romani
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  6. Anna Verri
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  7. Valeria Bargiggia
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  8. Vittorio Cosi
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Correspondence to Roberto Bergamaschi.

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Bergamaschi, R., Villani, S., Crabbio, M. et al. Inverse relationship between multiple sclerosis and allergic respiratory diseases. Neurol Sci 30, 115–118 (2009). https://doi.org/10.1007/s10072-009-0036-8

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  • DOI: https://doi.org/10.1007/s10072-009-0036-8

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