Abstract
Amyotrophic lateral sclerosis (ALS) is generally considered to be a paradigm of pure motor neuron disorder; nevertheless, the possible occurrence of cognitive impairment up to a frank dementia in patients affected by ALS is recognized. The appraisal of the cognitive impairment in ALS patients is crucial not only to the therapeutic trials of this incurable disease, but also to the planning of care, compliance to interventions, the end-of-life decisions. The cognitive/behavioral changes of ALS patients are consistent with frontotemporal dysfunctions; the overlap of neuropathological features of ALS and frontotemporal lobe degeneration (FTLD) supports, in addition, the putative spectrum of ALS and FTD. In the present review, the pertinent clinical, genetic, neuropathological, neuropsychological and neuroimaging data of the literature are comprehensively and critically discussed. The distinct and overlapping features of ALS and FTD are pointed out, as well as the undisclosed questions deserving additional studies.
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References
Murphy J, Henry R, Lomen-Hoert C (2006) Identification and categorization of frontotemporal dementia impairment in ALS. In: Strong MJ (ed) Dementia and motor neuron disease. Informa UK Ltd, Abingdon, pp 59–66
Strong MJ, Grace GM, Freedman M et al (2009) Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 10:131–146
Neumann M, Sampathu DM, Kwong LK et al (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314:130–133
Arai T, Hasegawa M, Akiyama H et al (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 351:602–611
Mackenzie IR, Feldman HH (2005) Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum. J Neuropathol Exp Neurol 64:730–739
Lillo P, Hodges JR (2009) Frontotemporal dementia and motor neuron disease: overlapping clinic-pathologic disorders. J Clin Neurosci 16:1131–1135
Geser F, VM-Y Lee, Trojanowski JQ (2010) Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology 30:103–112
Neumann M, Kwong LK, Sampathu DM et al (2007) TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol 64:1388–1394
Mackenzie IRA (2007) The neuropathology of FTD associated with ALS. Alzheimer Dis Assoc Disord 21:44–49
Ringholz GM, Appel SH, Bradshaw M et al (2005) Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology 65:586–590
Hamilton RL, Bowser R (2004) Alzheimer disease pathology in amyotrophic lateral sclerosis. Acta Neuropathol 107:515–522
Lomen-Hoerth C, Anderson T, Miller B (2002) The overlap of amyotrophic lateral sclerosis and frontotemporal dementia. Neurology 59:1077–1079
Kertesz A, Blair M, McMonagle P et al (2007) The diagnosis and course of frontotemporal dementia. Alzheimer Dis Assoc Disord 21:155–163
Neary D, Snowden JS, Gustafson L et al (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51:1546–1554
Hodges JR, Davies RR, Xuereb JH et al (2004) Clinicopathological correlates in frontotemporal dementia. Ann Neurol 56:399–406
Knopman DS, Boeve BF, Parisi JE et al (2005) Antemortem diagnosis of frontotemporal lobar degeneration. Ann Neurol 57:480–488
Mackenzie IR, Feldman H (2003) The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease. Acta Neuropathol 105:98–102
Hodges JR, Davies R, Xuereb J et al (2003) Survival in frontotemporal dementia. Neurology 61:349–354
Hu W, Seelar H, Josephs K (2009) Clinical and survival profiles of patients with frontotemporal dementia and motor neuron disease. Neurology 72 (Suppl 3) P09.163
Mc Clusky L, Elman L, Libon D (2009) ALS-dementia in a large population of patients with ALS and FTD. Neurology 72 (Suppl 3) S45.007
Magistrello M, Rota E, Caglio M (2009) The diagnosis of FTD-ALS: a longitudinal study in a specialized dementia unit. Neurol Sci 9:S266
Caselli RJ, Windebank AJ, Petersen RC et al (1993) Rapidly progressive aphasic dementia and motor neuron disease. Ann Neurol 33:200–207
Tsuchiya K, Ikeda K, Haga et al (2001) Atypical amyotrophic lateral sclerosis with dementia mimicking frontal Pick’sdisease: a report of an autopsy case with a clinical course of 15 years. Acta Neuropathol. 101:625–630
Olney RK, Murphy J, Forshew D et al (2005) The effects of executive and behavioral dysfunction on the course of ALS. Neurology 65:1774–1777
Raaphorst J, De Visser M, Linssen WH, De Haan RJ, Schmand B (2009) The cognitive profile of amyotrophic lateral sclerosis: a meta-analysis. Amyotroph Lateral Scler 29:1–13
Grossman AB, Woolley-Levine S, Bradley WG, Miller RG (2007) Detecting neurobehavioral changes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 8:56–61
Gibbons ZC, Richardson A, Neary D, Snowden JS (2008) Behaviour in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9:67–74
Lomen-Hoerth C, Murphy J, Langmore S et al (2003) Are amyotrophic lateral sclerosis patients cognitively normal? Neurology 60:1094–1097
Rakowicz WP, Hodges JR (1998) Dementia and aphasia in motor neuron disease: an underrecognised association? J Neurol Neurosurg Psychiatry 65:881–889
Murphy JM, Henry RG, Langmore S et al (2007) Continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch Neurol 64:530–534
Phukan J, Pender NP, Hardiman O (2007) Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol 6:994–1003
Bak TH, Hodges JR (2004) The effects of motor neurone disease on language: further evidence. Brain Lang 89:354–361
Doran M, Xuereb J, Odges JR (1995) Rapidly progressive aphasia with bulbar motor neurone disease: a clinical and neuropsycological study. Behav Neurol 8:169–180
Tsuchiya K, Ozawa E, Fukushima J et al (2000) Rapidly progressive aphasia and motor neuron disease: a clinical, radiological, and pathological study of an autopsy case with circumscribed lobar atrophy. Acta Neuropathol 99:81–87
Duffy JR, Peach RK, Strand EA (2007) Progressive apraxia of speech as a sign of motor neuron disease. Am J Speech Lang Pathol 16:198–208
Rippon GA, Scarmeas N, Gordon PH et al (2006) An observational study of cognitive impairment in amyotrophic lateral sclerosis. Arch Neurol 63:345–352
Abrahams S, Goldstein LH, Al-Chalabi A et al (1997) Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 62:464–472
Robinson KM, Lacey SC, Grugan P et al (2006) Cognitive functioning in sporadic amyotrophic lateral sclerosis: a six month longitudinal study. JNNP 77:668–670
Strong MJ, Grace GM, Orange JB et al (1999) A prospective study of cognitive impairment in ALS. Neurology 53:1665–1670
Abrahams S, Leigh PN, Goldstein LH (2005) Cognitive change in ALS: a prospective study. Neurology 64:1222–1226
Schreiber H, Gaigalat T, Wiedemuth-Catrinescu U et al (2005) Cognitive function in bulbar- and spinal-onset amyotrophic lateral sclerosis. A longitudinal study in 52 patients. J Neurol 252:772–781
Hosler BA, Siddique T, Sapp PC et al (2000) Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21–q22. JAMA 284:1664–1669
Vance C, Al-Chalabi A, Ruddy D et al (2006) Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2–21.3. Brain 129:868–876
Valdmanis PN, Dupre N, Bouchard JP et al (2007) Three families with amyotrophic lateral sclerosis and frontotemporal dementia with evidence of linkage to chromosome 9p. Arch Neurol 64:240–245
Le Ber I, Camuzat A, Berger E et al (2009) Chromosome 9p-linked families with fronto-temporal dementia associated with motor neuron disease. Neurology 72:1669–1676
Boxer A, Mackenzie R, Boeve BF et al (2010) Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family. J Neurol Neurosurg Psychiatry. doi:10.1136/jnnp.2009.204081
Gellera C, Colombrita C, Ticozzi N et al (2008) Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. Neurogenetics 9:33–40
Wicks P, Abrahams S, Papps B et al (2009) SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis. J Neurol 256:234–241
Belzil VV, Valdmanis PN, Dion PA et al (2009) Mutations in FUS cause FALS and SALS in French and French Canadian populations. Neurology 73:1176–1179
Chio A, Restagno G, Brunetti M et al (2009) Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation. Neurobiol Aging 30:1272–1275
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL et al (2009) Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323:1205–1208
Vance C, Rogelj B, Hortobagyi T et al (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323:1208–1211
Kirby J, Goodall EF, Smith W et al (2009) Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis. Neurogenetics doi 101007/s10048-009-0218-9
Baker M, Mackenzie IR, Pickering-Brown SM et al (2006) Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442:916–919
Pickering-Brown SM, Rollinson S, Du Plessis D et al (2008) Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations. Brain 131:721–731
Yu CE, Bird TD, Bekris LM et al (2010) The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Arch Neurol 67:161–170
Gitcho MA, Bigio EH, Mishra M et al (2009) TARDBP 3’-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathol 118:633–645
Gallone S, Giordana MT, Scarpini E et al (2009) Absence of TARDBP gene mutations in an Italian series of patients with frontotemporal lobar degeneration. Dement Geriatr Cogn Disord 28:239–243
Mackenzie IRA, Neumann M, Bigio EH et al (2010) Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 119:1–4
Cairns NJ, Neumann M, Bigio EH et al (2007) TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol 171:227–240
Wilson CM, Grace GM, Munots D, He BP, Strong MJ (2001) Cognitive impairment in sporadic ALS: a pathological continuum underlying a multisystem disorder. Neurology 57:651–657
Mackenzie IR, Bigio EH, Ince PG et al (2007) Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol 61:427–434
Liscic RM, Grinberg LT, Zidar J, Gitcho MA, Cairns NJ (2008) ALS and FTLD: two faces of TDP-43 proteinopathy. Eur J Neurol 15:772–780
Giordana MT, Piccinini M, Grifoni S et al (2010) TDP-43 redistribution is an early event in amyotrophic lateral sclerosis. Brain Pathol 20:351–360
Josephs KA, Parisi JE, Knopman DS et al (2006) Clinically undetected motor neuron disease in pathologically proven frontotemporal lobar degeneration with motor neuron disease. Arch Neurol 63:506–512
Brandmeir NJ, Geser F, Kwong LK et al (2007) Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease. Acta Neuropathol 115:147–149
Kawashima T, Doh-ura K, Kikuchi H et al (2001) Cognitive dysfunction in patients with amyotrophic lateral sclerosis is associated with spherical or crescent-shaped ubiquitinated intraneuronal inclusions in the parahippocampal gyrus and amygdala but not in the neostriatum. Acta Neuropathol 102:467–472
Kato S, Hayashi H, Yagishita A (1993) Involvement of the frontotemporal lobe and limbic system in amyotrophic lateral sclerosis: as assessed by serial computed tomography and magnetic resonance imaging. J Neurol Sci 116:52–58
Frank B, Haas J, Heinze HJ et al (1997) Relation of neuropsychological and magnetic resonance findings in amyotrophic lateral sclerosis: evidence for subgroups. Clin Neurol Neurosurg 99:79–86
Pioro EP (2006) Neuroimaging in ALS and ALS with frontotemporal dementia In: Strong MJ (ed) Dementia and motor neuron disease. Informa UK Ltd, Abingdon, pp 107–131
Lulè D, Ludolph AC, Kassubek J (2009) MRI-based functional neuroimaging in ALS: an update. Amyotroph Lateral Scler 10:258–268
Kew JJ, Goldstein LH, Leigh PN et al (1993) The relationship between abnormalities of cognitive function and cerebral activation in amyotrophic lateral sclerosis. A neuropsychological and positron emission tomography study. Brain 116:1399–1423
Abrahams S, Goldstein LH, Kew JJ et al (1996) Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET study. Brain 119:2105–2120
Talbot PR, Goulding PJ, Lloyd JJ et al (1995) Inter-relation between “classic” motor neuron disease and frontotemporaldementia: neuropsychological and single photon emission computed tomography study. J Neurol Neurosurg Psychiatry 58:541–547
Snowden J, Neary D, Mann D (2007) Frontotemporal lobar degeneration: clinical and pathological relationships. Acta Neuropathol 114:31–38
Chang JL, Lomen-Hoerth C, Murphy J et al (2005) A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD. Neurology 65:75–80
Whitwell JL, Jack CR Jr, Senjem ML, Josephs KA (2006) Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology 66:102–104
Nishihira Y, Tan C-H, Onodera O et al (2008) Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions. Acta Neuropathol 116:169–182
Jeong Y, Park KC, Cho SS et al (2005) Pattern of glucose hypometabolism in frontotemporal dementia with motor neuron disease. Neurology 64:734–736
Neary D, Snowden JS, Mann DM et al (1990) Frontal lobe dementia and motor neuron disease. J Neurol Neurosurg Psychiatry 53:23–32
Ishikawa T, Morita M, Nakano I (2007) Brain perfusion imaging in amyotrophic lateral sclerosis with dementia. Brain Nerve 10:1093–1098
Abe K, Fujimura H, Toyooka K et al (1993) Single-photon emission computed tomographic investigation of patients with motor neuron disease. Neurology 43:1569–1573
Abrahams S, Goldstein LH, Simmons A et al (2004) Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain 127:1507–1517
Wooley SC, York MK, Moore DH et al (2010) Detecting frontotemporal dysfunction in ALS: utility of the ALS Cognitive Behavioral Screen (ALS-CBSTM). Amyotroph Lateral Scler 11:303–311
Lillo P, Garcin B, Hornberger M et al (2010) Neurobehavioral features in frontotemporal dementia with amyotrophic lateral sclerosis. Arch Neurol 67:826–830
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Supported by Compagnia di San Paolo, Torino, Grant Grant 2004.1424, and Regione Piemonte, Ricerca Sanitaria Finalizzata, Grant 466.2008.
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Giordana, M.T., Ferrero, P., Grifoni, S. et al. Dementia and cognitive impairment in amyotrophic lateral sclerosis: a review. Neurol Sci 32, 9–16 (2011). https://doi.org/10.1007/s10072-010-0439-6
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DOI: https://doi.org/10.1007/s10072-010-0439-6