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Measurement of health-related quality of life in patients with chronic kidney disease in Japan with EuroQol (EQ-5D)

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Abstract

Background

Chronic kidney disease (CKD) is a health-related quality-of-life (HRQOL) deteriorating disease which is not only a public health but also a socioeconomic problem. Interest in developing cost-effective interventions to control CKD has increased. The aim of this study was to measure HRQOL in terms of quality-adjustment weights for cost-effectiveness analysis using EQ-5D in patients with CKD. The relationships between the measured HRQOL and clinical indices/complications were also analyzed.

Methods

EQ-5D, a generic preference-based instrument, was administered to 569 CKD outpatients at Tsukuba University Hospital between November and December 2008. The response rate was 94.4% (537/569). Data on sex, age, creatinine, hemoglobin, serum albumin and eGFR were obtained from the patients’ records. Data on the presence of complications such as hypertension, diabetes, and history of cardiovascular disease (CVD) were also retrieved.

Results

Measured quality-adjustment weights by the CKD stage were 0.940 (95% CI 0.915–0.965), 0.918 (0.896–0.940), 0.883 (0.857–0.909), 0.839 (0.794–0.884), and 0.798 (0.757–0.839) for stages 1–5, respectively. The decrease in weight was significant by ANOVA (P < 0.0001), and the weight for all stages was 0.885 (0.871–0.898). There was a positive relationship between hemoglobin/serum albumin and the weight. The presence of hypertension lowered the weight from 0.910 (0.885–0.936) to 0.874 (0.858–0.891), diabetes from 0.901 (0.886–0.917) to 0.840 (0.811–0.869), and CVD from 0.892 (0.878–0.906) to 0.783 (0.718–0.848).

Conclusions

HRQOL decreases with progression of CKD stage and/or presence of anemia, undernutrition, hypertension, diabetes, or history of CVD.

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Acknowledgments

This study was supported in part by a grant for a strategic outcome study project for chronic kidney disease and a grant for comprehensive research on cardiovascular and lifestyle-related diseases from the Ministry of Health, Labour and Welfare of Japan.

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Authors and Affiliations

  1. Department of Nephrology, Graduate School of Comprehensive Human Sciences, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Ten-oudai, Tsukuba, 305-8575, Ibaraki, Japan

    Reiko Tajima, Hirayasu Kai, Chie Saito, Shuichi Tsuruoka & Kunihiro Yamagata

  2. Department of Health Care Policy and Management, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    Masahide Kondo

  3. Department of Epidemiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

    Masafumi Okada, Hideto Takahashi & Mariko Doi

Authors
  1. Reiko Tajima
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  2. Masahide Kondo
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  3. Hirayasu Kai
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  4. Chie Saito
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  5. Masafumi Okada
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  6. Hideto Takahashi
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  7. Mariko Doi
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  8. Shuichi Tsuruoka
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  9. Kunihiro Yamagata
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Corresponding author

Correspondence to Kunihiro Yamagata.

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Tajima, R., Kondo, M., Kai, H. et al. Measurement of health-related quality of life in patients with chronic kidney disease in Japan with EuroQol (EQ-5D). Clin Exp Nephrol 14, 340–348 (2010). https://doi.org/10.1007/s10157-010-0304-1

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  • DOI: https://doi.org/10.1007/s10157-010-0304-1

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