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Endogenous endothelial cell signaling systems maintain vascular stability

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Abstract

The function of the endothelium is to provide a network to allow delivery of oxygen and nutrients to tissues throughout the body. This network comprises adjacent endothelial cells that utilize adherens junction proteins such as vascular endothelial cadherin (VE-cadherin) to maintain the appropriate level of vascular permeability. The disruption of VE-cadherin interactions during pathologic settings can lead to excessive vascular leak with adverse effects. Endogenous cell signaling systems have been defined, which help to maintain the proper level of vascular stability. Perhaps the best described system is Angiopoietin-1 (Ang-1). Ang-1 acting through its receptor Tie2 generates a well-described set of signaling events ultimately leading to enhanced vascular stability. In this review, we will focus on what is known about additional endogenous cell signaling systems that stabilize the vasculature, and using Ang-1/Tie2 as a model, we will address where our understanding of these additional systems is lacking.

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Acknowledgments

We thank D. Lim for expert graphical assistance. This work was funded by grants from the National Institutes of Health, Ruth L. Kirschstein National Research Service Award (N.R.L.); NHLBI (D.Y.L and K.J.W.); American Heart Association (K.J.W. and D.Y.L.); Juvenile Diabetes Research Foundation, HA and Edna Benning Foundation, and the Burroughs Wellcome Foundation (D.Y. L.).

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  1. Department of Medicine, University of Utah, 15 N 2030 E, Salt Lake City, UT, 84112-5330, USA

    Nyall R. London, Kevin J. Whitehead & Dean Y. Li

  2. Oncological Sciences, University of Utah, Salt Lake City, UT, 84112, USA

    Dean Y. Li

  3. Program in Molecular Medicine, University of Utah, Salt Lake City, UT, 84112, USA

    Nyall R. London, Kevin J. Whitehead & Dean Y. Li

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London, N.R., Whitehead, K.J. & Li, D.Y. Endogenous endothelial cell signaling systems maintain vascular stability. Angiogenesis 12, 149–158 (2009). https://doi.org/10.1007/s10456-009-9130-z

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