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Comparative Characterization of Cytokine Production by Concanavalin A-Activated Splenocytes from BALB/c and C57Bl/6 Mice after Cold Exposure

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Abstract

The level of cytokines produced by ConA activated splenocytes was studied in male BALB/c and C57Bl/6 mice after single and repeated cold exposure (−20°C, 3 min). Single cold exposure significantly decreased IL-2, -3, -4, -5, -10, -12, IFN-γ production in BALB/c mice and decreased IL-2 content and increased TNF-α level in C57Bl/6 mice. Repeated cold exposure normalized the content of IL-2, -4, -10, -12, and IFN-γ in BALB/c mice, which reflects the development of adaptive immune reactions. In C57Bl/6 mice IL-2, -3, -5, -10, -12, and IFN-γ production remained significantly decreased, which attested to dysadaptive processes.

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Correspondence to G. V. Trunova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 2, pp. 188–190, February, 2005

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Makarova, O.V., Trunova, G.V., Diatroptov, M.E. et al. Comparative Characterization of Cytokine Production by Concanavalin A-Activated Splenocytes from BALB/c and C57Bl/6 Mice after Cold Exposure. Bull Exp Biol Med 139, 220–222 (2005). https://doi.org/10.1007/s10517-005-0253-y

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  • DOI: https://doi.org/10.1007/s10517-005-0253-y

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