Skip to main content
SpringerLink
Log in

Kyotorphin suppresses proliferation and Ca2+ signaling in brown preadipocytes

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A positive correlation was revealed between stimulation of protein and DNA synthesis in preadipocytes by norepinephrine or neokyotorphin and intracellular Ca2+ concentration in these cells. Kyotorphin abolished the stimulatory effect of norepinephrine on proliferation of cultured cells and cold-induced [3H]-thymidine incorporation into DNA of mouse brown adipose tissue in vivo. These changes correlated with peptide-induced suppression of slow calcium signaling in preadipocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. R. Kh. Ziganshin, V. I. Sviryaev, B. V. Vas’kovskii, et al., Bioorg. Khim., 20, Nos. 8–9, 899–918 (1994).

    PubMed  CAS  Google Scholar 

  2. L. N. Medvedev and E. I. Elsukova, Brown Adipose Tissue. Molecular and Cellular Bases of Regulated Thermogenesis [in Russian], Krasnoyarsk (2002).

  3. E. Y. Blishchenko, O. V. Sazonova, O. A. Kalinina, et al., Peptides, 23, No. 5, 903–910 (2002).

    Article  PubMed  CAS  Google Scholar 

  4. G. Bronnikov, L. Dolgacheva, S. J. Zhang, et al., FEBS Lett., 407, No. 1, 73–77 (1997).

    Article  PubMed  CAS  Google Scholar 

  5. G. Bronnikov, J. Houstek, and J. Nedergaard, J. Biol. Chem., 267, No. 3, 2006–2013 (1992).

    PubMed  CAS  Google Scholar 

  6. B. Cannon and J. Nedergaard, Physiol. Rev., 84, No. 1, 277–359 (2004).

    Article  PubMed  CAS  Google Scholar 

  7. L. P. Dolgacheva, B. B. Abzhalelov, S. J. Zhang, et al., Cell. Signal., 15, No. 2, 209–216 (2003).

    Article  PubMed  CAS  Google Scholar 

  8. J. Himms-Hagen and D. Ricquier, Brown Adipose Tissue, In Handbook of Obesity, Eds. G. A. Bray, C. Bouchard, and W. P. T. James, New York (1997), pp. 415–441.

  9. J. M. Lindquist and S. Rehnmark, J. Biol. Chem., 273, No. 46, 30,147–30,156 (1998).

  10. S. Rehnmark and J. Nedergaard, Exp. Cell. Res., 180, No. 2, 574–579 (1989).

    Article  PubMed  CAS  Google Scholar 

  11. H. Wiesinger, S. Klaus, G. Heldmaier, et al., Can. J. Physiol. Pharmacol., 68, No. 2, 195–200 (1990).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, Russia

    G. E. Bronnikov, S. G. Kolaeva & L. P. Dolgacheva

  2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino

    L. I. Kramarova

Authors
  1. G. E. Bronnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. G. Kolaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. P. Dolgacheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. I. Kramarova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 184–186, February, 2006

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bronnikov, G.E., Kolaeva, S.G., Dolgacheva, L.P. et al. Kyotorphin suppresses proliferation and Ca2+ signaling in brown preadipocytes. Bull Exp Biol Med 141, 223–225 (2006). https://doi.org/10.1007/s10517-006-0133-0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-006-0133-0

Key Words

Search

Navigation