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Neuroprotective and Anti-ageing Effects of Curcumin in Aged Rat Brain Regions

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Abstract

This study investigated the influence of chronically administered curcumin on normal ageing-related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na+, K+, -adenosine triphosphatase (Na+, K+, -ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6- and 24-month-old rats. In normal ageing, lipid peroxidation and lipofuscin concentration were found to increase with ageing, the activities of SOD, GPx and Na+, K+, -ATPase, however, decreased with ageing. Chronic curcumin treatment of both 6 and 24 months old rats resulted in significant decreases in lipid peroxide and the lipofuscin contents in brain regions, the activities of SOD, GPx and Na+, K+, -ATPase however, showed significant increase in various brain regions. The present study, thus, demonstrated the antioxidative, antilipofusinogenesic and anti-ageing effects of curcumin in the brain.

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References

  • LR Barcley MR Vinqvist K Mukai H Goto Y Hashimoto A Tokunaga H Uno (2000) ArticleTitleOn the antioxidant mechanism of curcumin: classical methods are needed to determine antioxidant mechanism and activity Org Lett 7 2841–2843 Occurrence Handle10.1021/ol000173t

    Article  Google Scholar 

  • V Calabrese DA Butterfield AM Stella (2003) ArticleTitleNutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer’s disease Ital J Biochem 52 177–181 Occurrence Handle15141484 Occurrence Handle1:CAS:528:DC%2BD2cXhtVGisL%2FE

    PubMed  CAS  Google Scholar 

  • F Cardozo-pelaez PJ Brooks T Stedeford S Song J Sanchez-Ramos (2000) ArticleTitleDNA damage, repair and antioxidant systems in brain regions: a correlative study Free Radic Biol Med 28 779–785 Occurrence Handle10754274 Occurrence Handle1:CAS:528:DC%2BD3cXit1Wms7k%3D Occurrence Handle10.1016/S0891-5849(00)00172-6

    Article  PubMed  CAS  Google Scholar 

  • G Crambert M Fuzesi H Garty S Karlish K Greeing (2002) ArticleTitlePhospholemman (FXYDI) associate with Na+, K+-ATPase and regulate its transport properties Proc Natl Acad Sci USA 99 11476–11481 Occurrence Handle12169672 Occurrence Handle1:CAS:528:DC%2BD38XmslSlsrc%3D Occurrence Handle10.1073/pnas.182267299

    Article  PubMed  CAS  Google Scholar 

  • SD Deodhar R Sethi RC Srimal (1980) ArticleTitlePreliminary study on antirheumatic activity of curcumin (diferuloylmethane) Indian J Med Res 71 601–608

    Google Scholar 

  • IA Donatus InstitutionalAuthorNameSardjoko and Vermeulen NP (1990) ArticleTitleCytotoxic and cytoprotective activities of curcumin. Effect of paracetamol-induced cytotoxicity, lipid per oxidation and glutathione depletion in rat hepatocytes Biochem Pharmacol 39 1869–1875 Occurrence Handle2353930 Occurrence Handle1:CAS:528:DyaK3cXkvFWns7s%3D Occurrence Handle10.1016/0006-2952(90)90603-I

    Article  PubMed  CAS  Google Scholar 

  • H Esterbaur RJ Schaur H Zollner (1991) ArticleTitleChemistry and biochemistry of hydroxynonenal, malondialdehyde and related aldehydes Free Radic Biol Med 11 81–128 Occurrence Handle10.1016/0891-5849(91)90192-6

    Article  Google Scholar 

  • MS Feschenko C Donnet RK Wetzel NK Asinovski LR Jones KJ Sweadner (2003) ArticleTitlePhospholemman, a single-span membrane protein, is an accessory protein of Na+, K+ -ATPase in cerebellum and choroid plexus J Neurosci 23 2161–2169 Occurrence Handle12657675 Occurrence Handle1:CAS:528:DC%2BD3sXlsV2qsbc%3D

    PubMed  CAS  Google Scholar 

  • BL Fletcher CJ Dillard AL Tapple (1973) ArticleTitleMeasurement of fluorescent per oxidation products in biological systems and tissues Anal Biochem 52 1–9 Occurrence Handle4696687 Occurrence Handle1:CAS:528:DyaE3sXotFOhug%3D%3D Occurrence Handle10.1016/0003-2697(73)90327-8

    Article  PubMed  CAS  Google Scholar 

  • L Flohe WA Gunzler (1984) Assays of glutathione peroxidase P Packer (Eds) Methods of Enzymology NumberInSeriesVol: 105 Academic Press New York 114–121

    Google Scholar 

  • SA Frautschy W Hu P Kim SA Miller T Chu ME Herris-White GM Cole (2001) ArticleTitlePhenolic anti-inflammatory antioxidant reversal of a beta-induced cognitive deficits and neuropathology Neurobiol Aging 22 993–1005 Occurrence Handle11755008 Occurrence Handle1:CAS:528:DC%2BD3MXptFyksr0%3D Occurrence Handle10.1016/S0197-4580(01)00300-1

    Article  PubMed  CAS  Google Scholar 

  • W Fuller P Eatson JR Bell MJ Shattock (2003) ArticleTitleIschemia-induced Phosphorylation of phospholemman directly activates rat cardiac Na+, K+-ATPase FASEB 10 1096–1116

    Google Scholar 

  • PV Gopal AV Sriram D Sharma R Singh (2000) ArticleTitleGlutathione-S-transferase in the ageing rat brain cerebrum and the effect of chlorpromazine Gerontology 46 7–11 Occurrence Handle11111222 Occurrence Handle1:CAS:528:DC%2BD3cXmtFanug%3D%3D Occurrence Handle10.1159/000022126

    Article  PubMed  CAS  Google Scholar 

  • H Inano M Onoda N Inafuku M Kubota Y Kamada T Osawa H Kobayashi K Wakabayashi (2000) ArticleTitlePotent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats Carcinogenesis 21 1835–1841 Occurrence Handle11023541 Occurrence Handle1:CAS:528:DC%2BD3cXnslKmtL4%3D Occurrence Handle10.1093/carcin/21.10.1835

    Article  PubMed  CAS  Google Scholar 

  • SV Jovanovic CW Boone S Steenken M Trinoga RB Kaskey (2001) ArticleTitleHow curcumin works preferentially with water soluble antioxidants J Am Chem Soc 123 3064–3068 Occurrence Handle11457017 Occurrence Handle1:CAS:528:DC%2BD3MXhs1ymtrw%3D Occurrence Handle10.1021/ja003823x

    Article  PubMed  CAS  Google Scholar 

  • S Kaul TP Krishnakanth (1994) ArticleTitleEffect of retinal deficiency and curcumin or turmeric feeding on brain Na+, K+, -ATPase adenosine triphosphate activity Mol Cell Biochem 137 101–107 Occurrence Handle7845384 Occurrence Handle1:CAS:528:DyaK2MXitlehtbs%3D Occurrence Handle10.1007/BF00944071

    Article  PubMed  CAS  Google Scholar 

  • J Kaur D Sharma R Singh (1998) ArticleTitleRegional effects of ageing Na+, K+ -ATPase activity in rat brain and correlation with multiple unit action potentials and lipid peroxidation Indian J Biochem Biophys 35 364–371 Occurrence Handle10412231 Occurrence Handle1:CAS:528:DyaK1MXhsFeqsb4%3D

    PubMed  CAS  Google Scholar 

  • S Marklund G Marklund (1974) ArticleTitleInvolvement of the super oxide Anion radical in the autooxidation of pyrogallol and convenient assay for Super oxide Dismutase Eur J Biochem 47 469–474 Occurrence Handle4215654 Occurrence Handle1:CAS:528:DyaE2MXhtlGm Occurrence Handle10.1111/j.1432-1033.1974.tb03714.x

    Article  PubMed  CAS  Google Scholar 

  • T Masuda T Maekawa K Hidaka H Bando Y Takeda H Yamaguchi (2001) ArticleTitleChemical studies on antioxidant mechanisms of curcumin: analysis of oxidative coupling products from curcumin and linoleate J Agric Food Chem 49 2539–2547 Occurrence Handle11368633 Occurrence Handle1:CAS:528:DC%2BD3MXis1ylu70%3D Occurrence Handle10.1021/jf001442x

    Article  PubMed  CAS  Google Scholar 

  • MP Mattson (1998) ArticleTitleModification of ion homeostasis by lipid peroxidation: role of neuronal degeneration and adaptive plasticity Trends Neurosci 21 53–57 Occurrence Handle9498297 Occurrence Handle1:CAS:528:DyaK1cXhtFektL0%3D Occurrence Handle10.1016/S0166-2236(97)01188-0

    Article  PubMed  CAS  Google Scholar 

  • A Mukhopadhyay N Basu N Ghatak PK Gujral (1982) ArticleTitleAnti-inflammatory and irritant activities of curcumin analogues in rats Agents Actions 12 508–515 Occurrence Handle7180736 Occurrence Handle1:CAS:528:DyaL38XlslClt70%3D Occurrence Handle10.1007/BF01965935

    Article  PubMed  CAS  Google Scholar 

  • H Okhawa N Ohishi K Yagi (1979) ArticleTitleAssay for lipid peroxide in animal tissue by thiobarbituric acid reaction Ana Biochem 95 351–358 Occurrence Handle10.1016/0003-2697(79)90738-3

    Article  Google Scholar 

  • T Osawa Y Kato (2005) ArticleTitleProtective role of antioxidative food factors in oxidative stress caused by hyperglycemia Ann NY Acad Sci 1043 440–451 Occurrence Handle16037265 Occurrence Handle1:CAS:528:DC%2BD2MXpvVKqt7s%3D Occurrence Handle10.1196/annals.1333.050

    Article  PubMed  CAS  Google Scholar 

  • EJ Park CH Jeon G Ko J Kim DH Sohn (2000) ArticleTitleProtective effect of curcumin in rat liver injury induced by carbon tetrachloride J Pharm Pharmacol 52 437–440 Occurrence Handle10813555 Occurrence Handle1:CAS:528:DC%2BD3cXjtFWlsLk%3D Occurrence Handle10.1211/0022357001774048

    Article  PubMed  CAS  Google Scholar 

  • TN Patil M Srinevasan (1971) ArticleTitleHypocholesteremic effect of curcumin in induced-hypercholesteremic rats Indian J Exp Biol 9 167–169 Occurrence Handle5092727 Occurrence Handle1:CAS:528:DyaE3MXltVygs7g%3D

    PubMed  CAS  Google Scholar 

  • JT Piper SS Singhal MS Salameh RT Torman YC Awasthi S Awasthi (1998) ArticleTitleMechanism of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzyme in rat liver Int J Biochem Cell Biol 30 445–456 Occurrence Handle9675878 Occurrence Handle1:CAS:528:DyaK1cXksVSnsr0%3D Occurrence Handle10.1016/S1357-2725(98)00015-6

    Article  PubMed  CAS  Google Scholar 

  • JL Quiles C Aguilera MD Mesa MC Ramirez-Tortosa A Gil (1998) ArticleTitleAn ethanolic-aqueous extract of curcuma longa decrease the susceptibility of liver microsomes and mitochondria to lipid per oxidation in atherosclerotic Rabbit Biofactor 8 51–57 Occurrence Handle1:CAS:528:DyaK1cXltVGltrw%3D

    CAS  Google Scholar 

  • DV Rajakumar MN Rao (1994) ArticleTitleAntioxidant properties of dehydrozingerone and curcumin in rat brain homogenates Mol Cell Biochem 140 73–79 Occurrence Handle7877600 Occurrence Handle1:CAS:528:DyaK2MXivVSms7g%3D Occurrence Handle10.1007/BF00928368

    Article  PubMed  CAS  Google Scholar 

  • V Rajkrishnan P Vishwanathan KN Rajasekharan VP Menon (1999) ArticleTitleNeuroprotective role of curcumin from curcuma longa on ethanol-induced brain damage Phytother Res 13 571–574 Occurrence Handle10.1002/(SICI)1099-1573(199911)13:7<571::AID-PTR494>3.0.CO;2-7

    Article  Google Scholar 

  • A Ch Reddy BR Lokesh (1994) ArticleTitleStudies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and oxidation of ferrous ions Mol Cell Biochem 137 1–8 Occurrence Handle7845373 Occurrence Handle1:CAS:528:DyaK2cXmvFaktrY%3D Occurrence Handle10.1007/BF00926033

    Article  PubMed  CAS  Google Scholar 

  • A Ch Reddy BR Lokesh (1996) ArticleTitleEffect of turmeric (Curcuma longa) on iron-induced lipid per oxidation in the rat liver Food Chem Toxicol 32 279–283 Occurrence Handle10.1016/0278-6915(94)90201-1

    Article  Google Scholar 

  • S Riga D Riga (1974) ArticleTitleEffects of centrophenoxine on the lipofuscin pigments in nervous system of old rats Brain Res 72 265–275 Occurrence Handle4151704 Occurrence Handle1:CAS:528:DyaE2cXkvF2ms7w%3D Occurrence Handle10.1016/0006-8993(74)90864-6

    Article  PubMed  CAS  Google Scholar 

  • AJ Ruby G Kuttan KD Babu KN Rajasekharan R Kuttan (1995) ArticleTitleantitumor and antioxidant activity of natural curcuminoids Cancer Lett 94 79–83 Occurrence Handle7621448 Occurrence Handle1:CAS:528:DyaK2MXntFCksbs%3D Occurrence Handle10.1016/0304-3835(95)03827-J

    Article  PubMed  CAS  Google Scholar 

  • D Sharma AK Maurya R Singh (1993) ArticleTitleAge-related decline in multiple unit action potentials of CA3 regions of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine Neurobiol Aging 14 319–330 Occurrence Handle8367013 Occurrence Handle1:CAS:528:DyaK2cXhvVars7c%3D Occurrence Handle10.1016/0197-4580(93)90117-T

    Article  PubMed  CAS  Google Scholar 

  • RC Srimal BN Dhawan (1973) ArticleTitlePharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent J Pharm Pharmacol 25 447–452 Occurrence Handle4146582 Occurrence Handle1:CAS:528:DyaE3sXltVSmsb8%3D

    PubMed  CAS  Google Scholar 

  • N Sreejayan MN Rao (1994) ArticleTitleCurcumoids as potent inhibitors of lipid per oxidation J Pharm Pharmacol 46 1013–1016 Occurrence Handle7714712 Occurrence Handle1:STN:280:ByqB3s%2FkvVU%3D

    PubMed  CAS  Google Scholar 

  • M Srinivasan (1972) ArticleTitleEffect of curcumin on blood sugar as seen in diabetic subject Indian J Med Sci 26 269–270 Occurrence Handle4637293 Occurrence Handle1:STN:280:CSyD2M%2FntlM%3D

    PubMed  CAS  Google Scholar 

  • YM Sun HY Zhang DZ Chen CB Liu (2002) ArticleTitleTheoretical elucidation on the antioxidant mechanism of curcumin: a DFT study Org Lett 4 2909–29011 Occurrence Handle12182586 Occurrence Handle1:CAS:528:DC%2BD38XlsFyntrs%3D Occurrence Handle10.1021/ol0262789

    Article  PubMed  CAS  Google Scholar 

  • YJ Surh (1999) ArticleTitleMolecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances Mutat Res 428 305–327 Occurrence Handle10518003 Occurrence Handle1:CAS:528:DyaK1MXltlCqsbs%3D

    PubMed  CAS  Google Scholar 

  • Y Tanaka S Ando (1990) ArticleTitleSynaptic ageing as revealed by changes in membrane potential and decreased activity of Na+, K+-ATPase Brain Res 43 425–434

    Google Scholar 

  • M Thiyagarajan SS Sharma (2004) ArticleTitleNeuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats Life Sci 74 969–985 Occurrence Handle14672754 Occurrence Handle1:CAS:528:DC%2BD3sXps1GqsLw%3D Occurrence Handle10.1016/j.lfs.2003.06.042

    Article  PubMed  CAS  Google Scholar 

  • O Vajragupta P Boonchoong H Watanabe M Tohda N Kummasud Y Sumanont (2003) ArticleTitleManganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity Free Radic Biol Med 35 1632–1644 Occurrence Handle14680686 Occurrence Handle1:CAS:528:DC%2BD3sXpvVenu7s%3D Occurrence Handle10.1016/j.freeradbiomed.2003.09.011

    Article  PubMed  CAS  Google Scholar 

  • P Viani G Ceravto A Fiorilli B Cestaro (1991) ArticleTitleAge-related differences in synaptosomal peroxidative damage and membrane properties J Neurochem 56 253–258 Occurrence Handle1846172 Occurrence Handle1:CAS:528:DyaK3MXktVSmuw%3D%3D

    PubMed  CAS  Google Scholar 

  • S Watanabe T Fukui (2000) ArticleTitleSuppressive effect of curcumin on trichloroethane-induced oxidative stress J Nutr Sci Vitaminol (Tokyo) 46 230–234 Occurrence Handle1:CAS:528:DC%2BD3cXoslyqu7c%3D

    CAS  Google Scholar 

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  1. School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India

    Kiran Bala, B. C. Tripathy & Deepak Sharma

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  1. Kiran Bala
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  2. B. C. Tripathy
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  3. Deepak Sharma
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Correspondence to Deepak Sharma.

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Bala, K., Tripathy, B.C. & Sharma, D. Neuroprotective and Anti-ageing Effects of Curcumin in Aged Rat Brain Regions. Biogerontology 7, 81–89 (2006). https://doi.org/10.1007/s10522-006-6495-x

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