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Hormesis: why it is important to biogerontologists

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Abstract

This paper offers a broad assessment of the hormetic dose response and its relevance to biogerontology. The paper provides detailed background information on the historical foundations of hormesis, its quantitative features, mechanistic foundations, as well as how the hormesis concept could be further applied in the development of new therapeutic advances in the treatment of age-related diseases. The concept of hormesis has direct application to biogerontology not only affecting the quality of the aging process but also experimental attempts to extend longevity.

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Acknowlegements

Effort sponsored by the Air Force Office of Scientific Research, Air Force Material Command, USAF, under grant number FA9550-07-1-0248. The U.S. Government is authorized to reproduce and distribute for governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsement, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government. The sponsors had no role in study design, collection, analysis and interpretation of data, writing of the report and decision to submit the manuscript for publication.

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  1. Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA, 01003, USA

    Edward J. Calabrese

  2. Istituto di Medicina del Lavoro, Universitá Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Roma, Italy

    Ivo Iavicoli

  3. Department of Chemistry, University of Catania, Viale Andrea Doria, 95100, Catania, Italy

    Vittorio Calabrese

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  1. Edward J. Calabrese
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Calabrese, E.J., Iavicoli, I. & Calabrese, V. Hormesis: why it is important to biogerontologists. Biogerontology 13, 215–235 (2012). https://doi.org/10.1007/s10522-012-9374-7

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