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Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

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Abstract

Genetic variations in xenobiotic metabolizing genes can influence susceptibility to many environmentally induced cancers. Inheritance of the N-acetyltransferase 1 allele (NAT1*10), linked with increased metabolic activation of pro-carcinogens, is associated with an increased susceptibility to many cancers in which cigarette- or meat-derived carcinogens have been implicated in their etiology. The role of NAT1*10 in prostate cancer is under studied. Although cigarette smoking is not considered a risk factor for prostate cancer, a recent review suggests it may play a role in disease progression. Consequently, we examined the association of NAT1*10 with prostate cancer risk, grade, and stage among 400 Finnish male smokers using a case–control study design. Following genotyping of 206 patients and 196 healthy controls, our results do not support the role of NAT1*10 in relation to prostate cancer risk (OR = 1.28; 95% CI, 0.66–2.47), aggressive disease (OR = 0.58; 95% CI, 0.13–2.67), or advanced disease (OR = 1.19; 95% CI, 0.49–2.91).

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Acknowledgments

We thank Rama Modali and Kirsten Taylor for technical support and Mike Barrett, Kirk Snyder, and Tan Carly for data management. This study was supported in part by Public Health Service contracts NOl CN45165 and 45035 from the National Cancer Institute, United States Department of Health and Human Services.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville Health Sciences Center, 306 Clinical and Translational Research Building, 505 S. Hancock St., Louisville, KY, 40292, USA

    LaCreis R. Kidd & David W. Hein

  2. Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA

    LaCreis R. Kidd, Karen Woodson, Philip R. Taylor & Joseph A. Tangrea

  3. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA

    Demetrius Albanes

  4. Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland

    Jarmo Virtamo

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  1. LaCreis R. Kidd
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  2. David W. Hein
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  4. Philip R. Taylor
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Correspondence to LaCreis R. Kidd.

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Kidd, L.R., Hein, D.W., Woodson, K. et al. Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland. Biochem Genet 49, 73–82 (2011). https://doi.org/10.1007/s10528-010-9386-4

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