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Ultrasound-guided vacuum-assisted core breast biopsy: experience with 406 cases

  • EPIDEMIOLOGY
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to determine the indications, accuracy and complications of vacuum-assisted breast biopsy (VABB) performed using ultrasonographic (US) guidance for non-palpable lesions.

Materials and methods

This was a prospective study in which results from consecutive US-guided VABB performed between January 1999 and April 2003 were subsequently compared to those from excisional biopsy or to long-term follow-up imaging.

Results

Four hundred and six lesions were submitted to VABB procedures. Out of those, 78.9% were benign, 18.8% were malignant, 1.7% was lobular neoplasia, and 0.4% was atypical duct hyperplasia. Underestimation occurred in 2.6% of the cases and false negative results in 0.6%. Sensitivity to VABB was 97%, specificity went up to 100%, negative predictive value was 99%, positive predictive value was 100%, and accuracy was 99%. Complications occurred in 9% of the patients.

Conclusion

US-guided VABB is an accurate and safe procedure. The main indication is the non-palpable suspicious breast lesions (category 4). This new technique could be a good alternative for percutaneous and surgery biopsy.

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Acknowledgments

We thank the data manager Stefania Andrighetto and Simona Menna for their valuable work in organizing patient data.

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Authors and Affiliations

  1. Breast Imaging Unit, Department of Radiology, European Institute of Oncology, Milan, Italy

    Enrico Cassano, Maria Pizzamiglio & Francesca Abbate

  2. Radiology, Hospital de Clinicas, Curitiba, Parana, Brazil

    Linei A. B. D. Urban

  3. Epidemiology Unit, Department of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy

    Patrick Maisonneuve

  4. Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy

    Giuseppe Renne & Giuseppe Viale

  5. School of Medicine, University of Milan, Milan, Italy

    Giuseppe Viale & Massimo Bellomi

  6. Department of Radiology, European Institute of Oncology, Milan, Italy

    Massimo Bellomi

Authors
  1. Enrico Cassano
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  2. Linei A. B. D. Urban
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  3. Maria Pizzamiglio
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  4. Francesca Abbate
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  5. Patrick Maisonneuve
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  6. Giuseppe Renne
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  7. Giuseppe Viale
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  8. Massimo Bellomi
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Corresponding author

Correspondence to Linei A. B. D. Urban.

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Cassano, E., Urban, L.A.B.D., Pizzamiglio, M. et al. Ultrasound-guided vacuum-assisted core breast biopsy: experience with 406 cases. Breast Cancer Res Treat 102, 103–110 (2007). https://doi.org/10.1007/s10549-006-9305-x

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  • DOI: https://doi.org/10.1007/s10549-006-9305-x

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