Skip to main content

Advertisement

Log in

Dihydrofolate reductase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancer

  • Letter to the Editor
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Suzuki T, Matsuo K, Hirose K, Hiraki A, Kawase T, Watanabe M, Yamashita T, Iwata H, Tajima K (2008) One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 29:356–362

    Article  PubMed  CAS  Google Scholar 

  2. Jakubowska A, Gronwald J, Menkiszak J et al (2007) Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated with breast and ovarian cancer risk. Breast Cancer Res Treat 104:299–308

    Article  PubMed  CAS  Google Scholar 

  3. Martin DN, Boersma BJ, Howe TM, Goodman JE, Mechanic LE, Chanock SJ, Ambs S (2006) Association of MTHFR gene polymorphisms with breast cancer survival. BMC Cancer 6:257

    Article  PubMed  Google Scholar 

  4. Macis D, Maisonneuve P, Johansson H et al (2007) Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case–control study and a pooled meta-analysis. Breast Cancer Res Treat 106:263–271

    Article  PubMed  CAS  Google Scholar 

  5. Johnson WG, Stenroos ES, Spychala JR, Chatkupt S, Ming SX, Buyske S (2004) New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? Am J Med Genet 124A:339–345

    Article  Google Scholar 

  6. Gellekink H, Blom HJ, van der Linden IJM, den Heijer M (2007) Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. Eur J Hum Genet 15:103–109

    Article  PubMed  CAS  Google Scholar 

  7. Xu X, Gammon MD, Wetmur JG, Rao M, Gaudet MM, Teitelbaum SL, Britton JA, Neugut AI, Santella RM, Chen J (2007) A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users. Am J Clin Nutr 85:1098–1102

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aydan Eroglu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Çam, R., Eroglu, A., Egin, Y. et al. Dihydrofolate reductase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancer. Breast Cancer Res Treat 115, 431–432 (2009). https://doi.org/10.1007/s10549-008-0054-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-008-0054-x

Keywords

Navigation