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Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis

  • Epidemiology
  • Published:
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Abstract

Interleukin-1β (IL-1β), which is involved in inflammatory and immunological responses, plays an important role in the development and progression of breast cancer. Three functional single nucleotide polymorphisms (SNPs) identified in IL-1β gene are thought to influence breast cancer risk. The results of the association between IL-1β polymorphisms and breast cancer remain inconsistent. Therefore, we conducted a meta-analysis of eight case–control studies with rs1143627 (T > C), rs16944 (C > T), and rs1143634 (C > T). We found that the variant CC genotype of rs1143627 was associated with a significantly increased breast cancer risk (CC vs. TT: OR = 1.37, 95% CI = 1.10–1.70, P = 0.22 for heterogeneity; the recessive model CC vs. TT/TC: OR = 1.40, 95% CI = 1.17–1.67, P = 0.49 for heterogeneity). For rs16944 (C > T) and rs1143634 (C > T), no significant associations were found in all genetic models. In conclusion, the present meta-analysis suggests that rs1143627 is associated with breast cancer risk.

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Authors and Affiliations

  1. Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China

    Xiaoan Liu & Shui Wang

  2. Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, 210029, China

    Zhanwei Wang

  3. Dental Research Institute, School of Stomatology, Nanjing Medical University, Nanjing, 210029, China

    Jinhua Yu & Gang Lei

Authors
  1. Xiaoan Liu
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  2. Zhanwei Wang
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  3. Jinhua Yu
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  4. Gang Lei
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  5. Shui Wang
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Corresponding author

Correspondence to Shui Wang.

Additional information

Xiaoan Liu and Zhanwei Wang contributed equally to this work and should be considered as co-first authors.

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Liu, X., Wang, Z., Yu, J. et al. Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis. Breast Cancer Res Treat 124, 821–825 (2010). https://doi.org/10.1007/s10549-010-0910-3

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  • DOI: https://doi.org/10.1007/s10549-010-0910-3

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