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Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland)

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Abstract

Helicobacter pylori infection is an important risk factor for gastric cancer, but <3% of carriers of this organism will ever develop gastric cancer. Since inflammation plays a significant role in gastric carcinogenesis, it has been suggested that polymorphisms in genes involved in inflammatory response may partly explain why only a subgroup of patients infected with H. pylori develop gastric cancer. We compared relative frequencies of 17 single nucleotide polymorphisms (SNPs) in eight inflammation-related genes between 112 gastric cancer patients and 208 controls. Cases and controls were selected from a large cohort of Finnish male smokers who were recruited into the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. The studied SNPs were IL-1A (−889 C/T), IL-1B (−511 C/T and −31 T/C), IL-6 (−174 G/C and −597 G/A), IL-8 (−251 T/A, +396 T/G and +781 C/T), IL-8RA (Ex2 +860 G/C), IL-8RB (Exon 3 +1235 T/C, Exon 3 +811 C/T, and Exon 3 +1010 G/A), IL-10 (−819 C/T, −592 C/A, −1082 A/G), and TNF A (−308 G/A, −238 G/A). We found no statistically significant association between any of these SNPs, or the number of pro-inflammatory polymorphisms, with risk of gastric cancer. Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals.

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Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD, 20892-7232, USA

    Farin Kamangar, Christian C. Abnet, Sanford M. Dawsey, Demetrius Albanes & Philip R. Taylor

  2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Farin Kamangar, Craig J. Newschaffer, Kathy Helzlsouer & Yin Yao Shugart

  3. Core Genotyping Facility, Advanced Technology Center, National Cancer Institute/SAIC-Frederick, Inc., Gaithersburg, MD, USA

    Amy A. Hutchinson

  4. Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland

    Pirjo Pietinen & Jarmo Virtamo

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  1. Farin Kamangar
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Correspondence to Farin Kamangar.

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Kamangar, F., Abnet, C.C., Hutchinson, A.A. et al. Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland). Cancer Causes Control 17, 117–125 (2006). https://doi.org/10.1007/s10552-005-0439-7

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