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Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study

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Abstract

Vitamin D, a prosteroid hormone with anti-proliferative and pro-differentiation activity, is thought to act as a cancer chemopreventive agent. This study evaluated the association between vitamin D intake and breast cancer risk among women in a large prospective cohort study. A total of 34,321 postmenopausal women who had completed a questionnaire that included diet and supplement use were followed for breast cancer incidence from 1986 to 2004. Adjusted relative risks (RR) for breast cancer were calculated for dietary, supplemental, and total vitamin D intake among all women. The adjusted RR of breast cancer for women consuming >800 IU/day versus <400 IU/day total vitamin D was 0.89 (95% CI: 0.77–1.03). RRs were stronger among women with negative than positive ER or PR status. The association of high vitamin D intake with breast cancer was strongest in the first 5 years after baseline dietary assessment (RR = 0.66; 95% CI: 0.46–0.94 compared with lowest-intake group), and diminished over time. Changes in vitamin D intake over time might have contributed to the diminished association observed in later years. Vitamin D intake of >800 IU/day appears to be associated with a small decrease in risk of breast cancer among postmenopausal women. Studies evaluating all sources of vitamin D, especially sun exposure, are needed to fully understand the association between vitamin D and breast cancer risk.

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References

  1. American Cancer Society (2006) Cancer facts and figures 2006. American Cancer Society, Inc, Atlanta

    Google Scholar 

  2. Spina CS, Tangpricha V, Uskokovic M et al (2006) Vitamin D and cancer. Anticancer Res 26(4A):2515–2524

    PubMed  CAS  Google Scholar 

  3. Guyton KZ, Kensler TW, Posner GH (2003) Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutr Rev 61(7):227–238

    Article  PubMed  Google Scholar 

  4. Garland FC, Garland CF, Gorham ED, Young JF (1990) Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med 19(6):614–622

    Article  PubMed  CAS  Google Scholar 

  5. Gorham ED, Garland FC, Garland CF (1990) Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 19(4):820–824

    Article  PubMed  CAS  Google Scholar 

  6. Hanchette CL, Schwartz GG (1992) Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer 70(12):2861–2869

    Article  PubMed  CAS  Google Scholar 

  7. Lefkowitz ES, Garland CF (1994) Sunlight, vitamin D, and ovarian cancer mortality rates in US women. Int J Epidemiol 23(6):1133–1136

    Article  PubMed  CAS  Google Scholar 

  8. Grant WB (2002) An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 94(6):1867–1875

    Article  PubMed  Google Scholar 

  9. Institute of Medicine (1997) Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Institute of Medicine, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Washington, D.C

    Google Scholar 

  10. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B (2006) Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 84(1):18–28

    PubMed  CAS  Google Scholar 

  11. Zadshir A, Tareen N, Pan D, Norris K, Martins D (2005) The prevalence of hypovitaminosis D among US adults: data from the NHANES III. Ethn Dis 15(4 Suppl 5):S5–97–101

    Google Scholar 

  12. Tangpricha V, Turner A, Spina C et al (2004) Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. Am J Clin Nutr 80(6):1645–1649

    PubMed  CAS  Google Scholar 

  13. Weinstock MA, Lazovich D (2005) Tanning and vitamin D status. Am J Clin Nutr 82(3):707 author reply 707–708

    PubMed  CAS  Google Scholar 

  14. Shin MH, Holmes MD, Hankinson SE et al (2002) Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst 94(17):1301–1311

    PubMed  CAS  Google Scholar 

  15. McCullough ML, Rodriguez C, Diver WR et al (2005) Dairy, calcium, and vitamin D intake and postmenopausal breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 14(12):2898–2904

    Article  PubMed  CAS  Google Scholar 

  16. John EM, Schwartz GG, Dreon DM, Koo J (1999) Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971–1975 to 1992. National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev 8(5):399–406

    PubMed  CAS  Google Scholar 

  17. Levi F, Pasche C, Lucchini F, La Vecchia C (2001) Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91(2):260–263

    Article  PubMed  CAS  Google Scholar 

  18. Simard A, Vobecky J, Vobecky JS (1991) Vitamin D deficiency and cancer of the breast: an unprovocative ecological hypothesis. Can J Public Health 82(5):300–303

    PubMed  CAS  Google Scholar 

  19. Potischman N, Swanson CA, Coates RJ et al (1999) Intake of food groups and associated micronutrients in relation to risk of early-stage breast cancer. Int J Cancer 82(3):315–321

    Article  PubMed  CAS  Google Scholar 

  20. Witte JS, Ursin G, Siemiatycki J et al (1997) Diet and premenopausal bilateral breast cancer: a case–control study. Breast Cancer Res Treat. 42(3):243–251

    Article  PubMed  CAS  Google Scholar 

  21. Willett WC, Sampson L, Browne ML et al (1988) The use of a self-administered questionnaire to assess diet four years in the past. Am J Epidemiol 127(1):188–199

    PubMed  CAS  Google Scholar 

  22. Rimm EB, Giovannucci EL, Stampfer MJ et al (1992) Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 135(10):1114–1126 discussion 1127–1136

    PubMed  CAS  Google Scholar 

  23. Munger RG, Folsom AR, Kushi LH, Kaye SA, Sellers TA (1992) Dietary assessment of older Iowa women with a food frequency questionnaire: nutrient intake, reproducibility, and comparison with 24-hour dietary recall interviews. Am J Epidemiol 136(2):192–200

    PubMed  CAS  Google Scholar 

  24. Kushi LH, Fee RM, Folsom AR et al (1997) Physical activity and mortality in postmenopausal women. JAMA 277(16):1287–1292

    Article  PubMed  CAS  Google Scholar 

  25. Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65(4 Suppl):1220S–1228S discussion 1229S–1231S

    PubMed  CAS  Google Scholar 

  26. Hiatt RA, Krieger N, Lobaugh B et al (1998) Prediagnostic serum vitamin D and breast cancer. J Natl Cancer Inst 90(6):461–463

    Article  PubMed  CAS  Google Scholar 

  27. Janowsky EC, Lester GE, Weinberg CR et al (1999) Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk. Public Health Nutr 2(3):283–291

    Article  PubMed  CAS  Google Scholar 

  28. Bertone-Johnson ER, Chen WY, Holick MF et al (2005) Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 14(8):1991–1997

    Article  PubMed  CAS  Google Scholar 

  29. Kristal AR, Peters U, Potter JD (2005) Is it time to abandon the food frequency questionnaire? Cancer Epidemiol Biomarkers Prev 14(12):2826–2828

    Article  PubMed  Google Scholar 

  30. Houghton LA, Vieth R (2006) The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr 84(4):694–697

    PubMed  CAS  Google Scholar 

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Acknowledgments

The authors thank Aaron R. Folsom, MD, MPH for providing the Iowa Women’s Health Study data, and Ching Ping Hong, MS, and Lisa Harnack, DrPH, RD for consultation and assistance in data preparation prior to analysis. Funding: Funding for the Iowa Women’s Health Study was provided by the National Cancer Institute (R01 CA039742).

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Correspondence to Kim Robien.

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Robien, K., Cutler, G.J. & Lazovich, D. Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study. Cancer Causes Control 18, 775–782 (2007). https://doi.org/10.1007/s10552-007-9020-x

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  • DOI: https://doi.org/10.1007/s10552-007-9020-x

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