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Childhood hematopoietic malignancies and parental use of tobacco and alcohol: the ESCALE study (SFCE)

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Abstract

Objectives

Investigating the role of parental smoking and maternal alcohol consumption in the etiology of childhood hematopoietic malignancies.

Methods

The national registry-based case–control study ESCALE was carried out in France over the period 2003–2004. Population controls were frequency matched with the cases on age and gender. Maternal smoking and alcohol consumption during pregnancy and paternal smoking since before conception were reported by the mothers in a structured telephone questionnaire. Odds ratios (OR) were estimated using unconditional regression models closely adjusted for potential confounders.

Results

A total of 765 cases of acute leukemia (AL), 130 of Hodgkin’s lymphoma (HL), 165 of non-Hodgkin’s lymphoma (NHL) and 1681 controls were included. Paternal smoking was significantly associated with childhood ALL (OR = 1.4 [1.1–1.7]), AML (OR = 1.5 [1.0–2.3]), Burkitt (OR = 2.0 [1.2–3.2]), and anaplastic large cell (OR = 3.2 [1.2–9.1]) NHL. For the four diseases, the ORs significantly increased with the number of cigarettes smoked. No association with HL or with other types of NHL was observed. The associations with maternal alcohol consumption and cigarette smoking during pregnancy were less consistent.

Conclusion

The results support the hypothesis that only paternal smoking, and not maternal alcohol consumption or cigarette smoking, plays a role in childhood hematopoietic malignancies.

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Abbreviations

AL:

Acute leukemia

ALL:

Acute lymphoblastic leukemia

AML:

Acute myeloblastic leukemia

HL:

Hodgkin’s lymphoma

NHL:

Non-Hodgkin’s lymphoma

CI:

Confidence interval

OR:

Odds ratio

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Acknowledgments

We are grateful to: Marie-Hélène Da Silva and Christophe Steffen (INSERM U754), who coordinated the recruitment of the cases; Aurélie Goubin and the staff of the French National Registry of Childhood Blood Malignancies, who contributed to case detection and verification; Sabine Mélèze and Marie-Anne Noel (Institut CSA), who coordinated the selection of the controls and the interviews; and Catherine Tricoche (Callson) and the team of interviewers, who interviewed the cases and the controls. This work was supported by grants from INSERM, the Fondation de France, the Association pour la Recherche sur le Cancer (ARC), the Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS), the Agence Française de Sécurité Sanitaire de l’Environnement et du Travail (AFSSET), the association Cent pour sang la vie the Institut National du Cancer (INCa), and the Agence Nationale de la Recherche (ANR).

Author information

Authors and Affiliations

  1. INSERM, U754, IFR69, 16, AV. Paul Vaillant Couturier, 94807, Villejuif Cedex, France

    Jérémie Rudant, Florence Menegaux, Denis Hémon & Jacqueline Clavel

  2. Univ Paris-Sud, UMR-S754, IFR69, Villejuif Cedex, France

    Jérémie Rudant, Florence Menegaux, Denis Hémon & Jacqueline Clavel

  3. AP HP, Hôpital Armand Trousseau, Paris, France

    Guy Leverger

  4. Université Pierre et Marie Curie, Paris 6, France

    Guy Leverger

  5. AP HP, Hôpital Saint-Louis and Hôpital Robert-Debré, Paris, France

    André Baruchel

  6. Hôpital Jeanne de Flandre, Lille, France

    Anne Lambilliotte

  7. Hôpital Debrousse, Lyon, France

    Yves Bertrand

  8. Institut Gustave Roussy, Villejuif Cedex, France

    Catherine Patte

  9. Institut Curie, Paris, France

    Hélène Pacquement

  10. Hôpital Pellegrin Tripode, Bordeaux, France

    Cécile Vérité

  11. Hôpital des Enfants, Toulouse, France

    Alain Robert

  12. Hôpital La Timone, Marseille, France

    Gérard Michel

  13. Hôpital Arnaud de Villeneuve, Montpellier, France

    Geneviève Margueritte

  14. CHU-hôpital Sud, Rennes, France

    Virginie Gandemer

  15. French National Registry of Childhood Blood malignancies (RNHE), Villejuif Cedex, France

    Jacqueline Clavel

Authors
  1. Jérémie Rudant
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  2. Florence Menegaux
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  3. Guy Leverger
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  4. André Baruchel
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  5. Anne Lambilliotte
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  6. Yves Bertrand
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  7. Catherine Patte
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  8. Hélène Pacquement
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  9. Cécile Vérité
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  10. Alain Robert
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  11. Gérard Michel
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  12. Geneviève Margueritte
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  13. Virginie Gandemer
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  14. Denis Hémon
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  15. Jacqueline Clavel
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Corresponding author

Correspondence to Jérémie Rudant.

Additional information

SFCE: Société Française de lutte contre les Cancers de l’Enfant et de l’Adolescent.

Appendix

Appendix

SFCE Investigators of the ESCALE study

Principal investigator

Degree

Hospital

City (France)

André Baruchel

MD

Saint-Louis/Robert Debré

Paris

Claire Berger

MD

Centre Hospitalier Universitaire

Saint-Etienne

Christophe Bergeron

MD

Centre Léon Bérard

Lyon

Jean-Louis Bernard

MD

La Timone

Marseille

Yves Bertrand

MD

Debrousse

Lyon

Pierre Bordigoni

MD

Centre Hospitalier Universitaire

Nancy

Patrick Boutard

MD

Centre Hospitalier Régional Universitaire

Caen

Gérard Couillault

MD

Hôpital d’Enfants

Dijon

Lionel De Lumley

MD

Centre Hospitalier Régional Universitaire

Limoges

Anne-Sophie Defachelles

MD

Centre Oscar Lambret

Lille

François Demeocq

MD

Hôtel-Dieu

Clermont-Ferrand

Alain Fischer

MD

Hôpital des Enfants Malades

Paris

Virginie Gandemer

MD

Centre Hospitalier Universitaire – Hôpital Sud

Rennes

Olivier Hartmann

MD

Institut Gustave Roussy

Villejuif

Jean-Pierre Lamagnere

MD

Centre Gatien de Clocheville

Tours

Françoise Lapierre

MD

Centre Hospitalier Universitaire Jean Bernard

Poitiers

Guy Leverger

MD

Trousseau

Paris

Patrick Lutz

MD

Hôpital de Hautepierre

Strasbourg

Geneviève Margueritte

MD

Arnaud de Villeneuve

Montpellier

Françoise Mechinaud

MD

Hôpital Mère et Enfants

Nantes

Gérard Michel

MD

La Timone

Marseille

Frédéric Millot

MD

Centre Hospitalier Universitaire Jean Bernard

Poitiers

Martine Münzer

MD

American Memorial Hospital

Reims

Brigitte Nelken

MD

Jeanne de Flandre

Lille

Hélène Pacquement

MD

Institut Curie

Paris

Brigitte Pautard

MD

Centre Hospitalier Universitaire

Amiens

Yves Perel

MD

Pellegrin Tripode

Bordeaux

Alain Pierre-Kahn

MD

Enfants Malades

Paris

Emmanuel Plouvier

MD

Centre Hospitalier Régional

Besançon

Xavier Rialland

MD

Centre Hospitalier Universitaire

Angers

Alain Robert

MD

Hôpital des Enfants

Toulouse

Hervé Rubie

MD

Hôpital des Enfants

Toulouse

Nicolas Sirvent

MD

L’Archet

Nice

Christine Soler

MD

Fondation Lenval

Nice

Danièle Sommelet

MD

Centre Hospitalier Universitaire

Nancy

Jean-Pierre Vannier

MD

Charles Nicolle

Rouen

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Rudant, J., Menegaux, F., Leverger, G. et al. Childhood hematopoietic malignancies and parental use of tobacco and alcohol: the ESCALE study (SFCE). Cancer Causes Control 19, 1277–1290 (2008). https://doi.org/10.1007/s10552-008-9199-5

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