Abstract
Objective
We examine the association of antioxidants and 15-isoprostane F2t with risk of prostate cancer.
Methods
We conducted a nested case–control study of serum antioxidant biomarkers (selenium, tocopherols, carotenoids, and retinol) and a urinary oxidation biomarker (15-isoprostane F2t) with risk of prostate cancer within the Multiethnic Cohort. Demographic, dietary, and other exposure information was collected by self-administered questionnaire in 1993–1996. We compared prediagnostic biomarker levels from 467 prostate cancer cases and 936 cancer free controls that were matched on several variables. Multivariate conditional logistic regression models were used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CIs).
Results
We observed that there was no overall association of serum concentrations of antioxidants and urinary concentrations of 15-isoprostane F2t with risk of prostate cancer or risk of advanced prostate cancer. However, we did observe an inverse association for serum selenium only among African-American men (p trend = 0.02); men in the third tertile of selenium concentrations had a 41% lower risk (95% CI: 0.38–0.93) of prostate cancer when compared to men in the first tertile.
Conclusions
Overall, our study found no association of serum antioxidants or 15-isoprostane F2t with the risk of prostate cancer. The observed inverse association of selenium with prostate cancer in African-Americans needs to be validated in other studies.
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Acknowledgments
This study has been supported by the National Cancer Institute grants P01 CA 33619 and R37 CA 54281. One of the authors (JKG) was supported by a postdoctoral fellowship on Grant R25 CA 90956.
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This work was performed at the Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii.
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Gill, J.K., Franke, A.A., Steven Morris, J. et al. Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F2t in serum or urine with prostate cancer risk: the multiethnic cohort. Cancer Causes Control 20, 1161–1171 (2009). https://doi.org/10.1007/s10552-009-9304-4
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DOI: https://doi.org/10.1007/s10552-009-9304-4