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Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study

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Abstract

Objective

Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and the incidence of cancer.

Methods

The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days were defined as (lifetime exposure-days) × (exposure intensity score). Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders.

Results

Overall cancer risk was slightly increased among terbufos users [HR 1.21 (1.06–1.37)]. Suggestive associations were observed between terbufos use and cancers of the prostate (HRhighest tertile = 1.21; 95% CI = 0.99–1.47) and lung (HRmiddle tertile = 1.45; 95% CI = 0.95–2.22) and leukemia (HRmiddle tertile = 2.38; 95% CI = 1.35–4.21) and non-Hodgkin’s lymphoma (HRmiddle tertile = 1.94; 95% CI = 1.16–3.22), although the exposure–response gradients were non-monotonic and p for trends were not significant.

Conclusion

We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos.

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Acknowledgments

This work was supported [in part] by the intramural research program of the National Institutes of Health, the National Institute of Environmental Health Sciences (Z01-ES049030-11), and National Cancer Institute (Z01-CP010119).

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Authors and Affiliations

  1. Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, 270 Farber Hall, Buffalo, NY, USA

    Matthew R. Bonner & Brent A. Williams

  2. Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Jennifer A. Rusiecki

  3. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA

    Aaron Blair, Laura E. Beane Freeman, Mustafa Dosemeci & Michael C. R. Alavanja

  4. Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA

    Jane A. Hoppin & Dale P. Sandler

  5. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA

    Jay Lubin

Authors
  1. Matthew R. Bonner
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  2. Brent A. Williams
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  3. Jennifer A. Rusiecki
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  4. Aaron Blair
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  5. Laura E. Beane Freeman
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  6. Jane A. Hoppin
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  7. Mustafa Dosemeci
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  8. Jay Lubin
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  9. Dale P. Sandler
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  10. Michael C. R. Alavanja
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Correspondence to Matthew R. Bonner.

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Bonner, M.R., Williams, B.A., Rusiecki, J.A. et al. Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study. Cancer Causes Control 21, 871–877 (2010). https://doi.org/10.1007/s10552-010-9514-9

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  • DOI: https://doi.org/10.1007/s10552-010-9514-9

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