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Invadopodia: Specialized Cell Structures for Cancer Invasion

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Abstract

The spread of cancer cells to distant sites in the body is the major cause of cancer patient death. Growing evidence connects specialized subcellular structures, invadopodia, to cancer invasion and metastasis. Invadopodia, or invasive foot processes, are actin-rich protrusions that localize matrix-degrading activity to cell-substratum contact points and represent sites where cell signaling, proteolytic, adhesive, cytoskeletal, and membrane trafficking pathways physically converge. Understanding how invadopodia form and function should aid in the identification of novel targets for anti-invasive therapy.

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Abbreviations

ADAM:

a disintegrin and metalloproteinase

ECM:

extracellular matrix

ERK:

extracellular signal-regulated kinase

FAK:

focal adhesion kinase

MMP:

matrix metalloproteinase

N-WASp:

Neural Wiskott-Aldrich Syndrome Protein

Tks5/FISH:

Tyrosine kinase substrate 5/Five SH3 domains

WASp:

Wiskott-Aldrich Syndrome Protein

WAVE:

WASp-family Verprolin-homologous protein

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Acknowledgements

Many thanks to Drs. Laura Spinardi and Pier Carlo Marchisio for the provision of unpublished data. Thanks also to Dr. Susette Mueller for provision of both an EM image (reprinted from Oncogene) and for sending us journal articles in advance of publication, including Artym et al., Cancer Research, 2006. Apologies are made in advance for studies that were not discussed due to space limitations. This work was supported by NIH K22 CA109590-01 and Vanderbilt Development Funds to AMW. Thanks to Dr. Vito Quaranta for many insightful discussions and to Dr. Lynn Matrisian for critical reading of the manuscript.

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  1. Departments of Cancer Biology and Pathology, Vanderbilt University Medical Center, Room 448 Preston Research Building, 23rd Ave S @ Pierce, Nashville, TN, 37232, USA

    Alissa M. Weaver

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Correspondence to Alissa M. Weaver.

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Weaver, A.M. Invadopodia: Specialized Cell Structures for Cancer Invasion. Clin Exp Metastasis 23, 97–105 (2006). https://doi.org/10.1007/s10585-006-9014-1

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