Abstract
The development of Crohn’s disease (CD) is related to an interaction of genetic and environmental factors, with tobacco smoking being one of the most commonly studied environmental factors. In 1998, the Vienna classification was created to define CD by using three accepted clinical variables: age at diagnosis, disease behavior, and disease location. In this qualitative systematic review, articles examining the relationship between smoking and CD, using variables outlined in the Vienna classification, were identified utilizing multiple health databases. Current smoking was found to be associated with late-onset CD (≥40 years old) and current smokers were more likely to progress to stricturing or penetrating type CD than were nonsmoking patients. Conflicting evidence exists regarding the relationship between smoking with respect to CD disease location. The Vienna classification is an important tool in permitting comparisons and predicting clinical course among CD cases, especially when smoking status is taken into account.
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Loftus EV Jr (2004) Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126(6):1504–1517
Gasche C, Scholmerich J, Brynskov J, D’Haens G, Hanauer SB, Irvine EJ, Jewell DP, Rachmilewitz D, Sachar DB, Sandborn WJ, Sutherland LR (2000) A simple classification of Crohn’s disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 6(1):8–15
Baron S, Turck D, Leplat C, Merle V, Gower-Rousseau C, Marti R, Yzet T, Lerebours E, Dupas JL, Debeugny S, Salomez JL, Cortot A, Colombel JF (2005) Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study. Gut 54(3):357–363
Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B (1988) Ulcerative colitis and Crohn’s disease in an unselected population of monozygotic and dizygotic twins: a study of heritability and the influence of smoking. Gut 29(7):990–996
Corrao G, Tragnone A, Caprilli R, Trallori G, Papi C, Andreoli A, Di Paolo M, Riegler G, Rigo GP, Ferrau O, Mansi C, Ingrosso M, Valpiani D(1998) Risk of inflammatory bowel disease attributable to smoking, oral contraception and breastfeeding in Italy: a nationwide case-control study. Int J Epidemiol 27(3):397–404
Somerville KW, Logan RF, Edmond M, Langman MJ (1984) Smoking and Crohn’s disease. Br Med J (Clin Res Ed) 289(6450):954–956
Tobin MV, Logan RF, Langman MJ, McConnell RB, Gilmore IT (1989) Cigarette smoking and inflammatory bowel disease. Gastroenterology 93(2):316–321
Silverstein MD, Lashner BA, Hanauer SB, Evans AA, Kirsner JB (1989) Cigarette smoking in Crohn’s disease. Am J Gastroenterol 84(1):31–33
Garcia Rodriguez LA, Gonzalez-Perez A, Johansson S, Wallander MA (2005) Risk factors for inflammatory bowel disease in the general population. Aliment Pharmacol Ther 22(4):309–315
Calkins BM (1989) A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 34(12):1841–1854
Farmer RG, Hawk WA, Turnbull RB Jr (1975) Clinical patterns in Crohn’s disease: a statistical study of 615 cases. Gastroenterology 68:627–635
Regueiro M, Kip KE, Cheung O, Hegazi RA, Plevy S (2005) Cigarette smoking and age at diagnosis of inflammatory bowel disease. Inflamm Bowel Dis 11(1):42–47
Lashner BA, Shaheen NJ, Hanauer SB, Kirschner BS (1993) Passive smoking is associated with an increased risk of developing inflammatory bowel disease in children. Am J Gastroenterol 88(3):356–359
Persson PG, Ahlbom A, Hellers G (1990) Inflammatory bowel disease and tobacco smoke- a case-control study. Gut 31(12):1377–1381
Franceschi S, Panza E, La Vecchia C, Parazzini F, Decarli A, Bianchi PG (1987) Nonspecific inflammatory bowel disease and smoking. Am J Epidemiol 125(3):445–452
Aldhous MC, Drummond HE, Arnott DR, Smith L, Satsangi J (2005) Effect of smoking habit and load on clinical presentation and progression in Crohn’s disease and ulcerative colitis. BSG Abstracts, A2
Bustamante M, Nos P, Hoyos M, Hinojosa J, Moles JR, Garcia-Herola A, Berenguer J (1998) Relationship between smoking and colonic involvement in inflammatory bowel disease. Rev Esp Enferm Dig 90(12):833–840
Russel MG, Volovics A, Schoon EJ, van Wijlick EH, Logan RF, Shivananda S, Stockbrugger RW (1998) Inflammatory bowel disease: Is there any relation between smoking status and disease presentation? European Collaborative IBD Study Group. Inflamm Bowel Dis 4:182–186
Cosnes J, Carbonnel F, Beaugerie L, Le Quintrec Y, Gendre JP (1996) Effects of cigarette smoking on the long-term course of Crohn’s disease. Gastroenterology 110(2):424–431
Lindberg E, Jarnerot G, Huitfeldt B (1992) Smoking in Crohn’s disease: effect on localisation and clinical course. Gut 33(6):779–782
Benoni C, Nilsson A (1984) Smoking habits in patients with inflammatory bowel disease. Scand J Gastroenterol 19(6):824–830
Holdstock G, Savage D, Harman M, Wright R (1984) Should patients with inflammatory bowel disease smoke? Br Med J (Clin Res Ed) 288(6414):362
Picco MF, Bayless TM (2003) Tobacco consumption and disease duration are associated with fistulizing and stricturing behaviors in the first 8 years of Crohn’s disease. Am J Gastroenterol 98(2):363–368
Louis E, Michel V, Hugot JP, Reenaers C, Fontaine F, Delforge M, El Yafi F, Colombel JF, Belaiche J (2003) Early development of stricturing or penetrating pattern in Crohn’s disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype. Gut 52(4):552–557
Lautenbach E, Berlin JA, Lichtenstein GR (1998) Risk factors for early postoperative recurrence of Crohn’s disease. Gastroenterology 115(2):259–267
Rocca G, Astegiano M, Sostegni R, Fiorentini MT, Musso A, Bresso F, Greco S, Ponti V, Demarchi B, Rizzetto M, Pera A (1997) Effect of current smoking on the clinical presentation, medical therapy, and surgical therapy of Crohn’s disease. Gastroenterology 112:A1074
Breuer-Katschinski BD, Hollander N, Goebell H (1996) Effect of cigarette smoking on the course of Crohn’s disease. Eur J Gastroenterol Hepatol 8(3):225–228
Cosnes J, Cattan S, Blain A, Beaugerie L, Carbonnel F, Parc R, Gendre JP (2002) Long-term evolution of disease behavior of Crohn’s disease. Inflamm Bowel Dis 8(4):244–250
Louis E, Collard A, Oger AF, Degroote E, Aboul Nasr El Yafi FA, Belaiche J (2001) Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease. Gut 49(6):777–782
Bernell O, Lapidus A, Hellers G (2000) Risk factors for surgery and postoperative recurrence in Crohn’s disease. Ann Surg 231(1): 38–45
Greenstein AJ, Lachman P, Sachar DB, Springhorn J, Heimann T, Janowitz HD, Aufses AH Jr (1988) Perforating and non-perforating indications for repeated operations in Crohn’s disease: evidence for two clinical forms. Gut 29(5):588–592
Sachar DB, Andrews HA, Farmer RG, Pallone F, Pena AS, Prantera C, Rutgeerts P (1992) Proposed classification of patient subgroups in Crohn’s disease. Gastroenterol Int 5:141–154
Ekbom A, Helmick C, Zack M, Adami HO (1991) The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden. Gastroenterology 100(2):350–358
Devlin HB, Datta D, Dellipiani AW (1980) The incidence and prevalence of inflammatory bowel disease in North Tees Health District. World J Surg 4(2):183–193
Lee FI, Costello FT (1985) Crohn’s disease in Blackpool—incidence and prevalence 1968–80. Gut 26(3):274–278
Freeman HJ (2005) Age-dependant phenotypic clinical expression of Crohn’s disease. J Clin Gastroenterol 39(9):774–777
Polito JM, Childs B, Mellits ED, Tokayer AZ, Harris ML, Bayless TM (1996) Crohn’s disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology 111(3):580–586
Brant SR, Picco MF, Achkar JP, Bayless TM, Kane SV, Brzezinski A, Nouvet FJ, Bonen D, Karban A, Dassopoulos T, Karaliukas R, Beaty TH, Hanauer SB, Duerr RH, Cho JH (2003) Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn’s disease phenotypes. Inflamm Bowel Dis 9(5):281–289
Lesage S, Zouali H, Cezard JP, Colombel JF, Belaiche J, Almer S, Tysk C, O’Morain C, Gassull M, Binder V, Finkel Y, Modigliani R, Gower-Rousseau C, Macry J, Merlin F, Chamaillard M, Jannot AS, Thomas G, Hugot JP, EPWG-IBD Group, EPIMAD Group, GETAID Group (2002) CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet 70(4):845–857
CDC (2004) State-specific prevalance of current cigarette smoking among adults: United States, 2003. MMWR 53:1035–1037
Jewell T, Robeson S (2004) Smoking during pregnancy: update continuing to place Kentucky’s children at risk. Kentucky Epidemiol NotesRep 39(Nov):1–6
Mahid SS, Minor KS, Stromberg A, Galandiuk S (in press) Active and passive smoking in childhood is related to the development of inflammatory bowel disease. Inflamm Bowel Dis
Veloso FT, Ferreira JT, Barros L, Almeida S (2001) Clinical outcome of Crohn’s disease: analysis according to the Vienna classification and clinical activity. Inflamm Bowel Dis 7(4):306–313
Present DH (2005) Management of fistula disease. Inflamm Bowel Dis 4:302–307
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Mahid, S.S., Minor, K.S., Stevens, P.L. et al. The Role of Smoking in Crohn’s Disease as Defined by Clinical Variables. Dig Dis Sci 52, 2897–2903 (2007). https://doi.org/10.1007/s10620-006-9624-0
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DOI: https://doi.org/10.1007/s10620-006-9624-0