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The mouse pattern electroretinogram

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Abstract

Mouse models of optic nerve disease such as glaucoma, optic neuritis, ischemic optic neuropathy, and mitochondrial optic neuropathy are being developed at increasing rate to investigate specific pathophysiological mechanisms and the effect of neuroprotective treatments. The use of these models may be greatly enhanced by the availability of non-invasive methods able to monitor retinal ganglion cell (RGC) function longitudinally such as the Pattern Electroretinogram (PERG). While the use of the PERG as a tool to probe inner retina function in mammals is known since 25 years, relatively less information is available for the mouse. Here, the PERG technique and the main applications in the mouse are reviewed.

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Acknowledgement

Financial support: NIH RO3 EY016322, NIH RO1 EY014957, NIH center grant P30-EY14801, unrestricted grant to the University of Miami from Research to Prevent Blindness, Inc.

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  1. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Vittorio Porciatti

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  1. Vittorio Porciatti
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Correspondence to Vittorio Porciatti.

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Porciatti, V. The mouse pattern electroretinogram. Doc Ophthalmol 115, 145–153 (2007). https://doi.org/10.1007/s10633-007-9059-8

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  • DOI: https://doi.org/10.1007/s10633-007-9059-8

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