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Nitric oxide and clustering of metabolic syndrome components in pediatrics

  • PEDIATRIC EPIDEMIOLOGY
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Abstract

This study was performed to determine the risk factor pattern of the metabolic syndrome (MetS) in association with serum nitric oxide metabolites (NO x ) in children and adolescents. The study included 851 children and adolescents, aged 4–19 years. The MetS was defined according to modified Adult treatment Panel III criteria. Cluster analysis was performed using principle components analysis with varimax orthogonal rotation to examine the risk factor pattern of the MetS. The prevalence of MetS was 10.8 and 10.0% in males and females, respectively. Age-and sex-adjusted odds ratio of having MetS was significantly higher in the upper quartile of NO x compared to the lower quartile (2.2, 95% CI: 1.1–4.7, p = 0.029). In the whole population, three factors were identified including blood pressure/obesity, lipid/obesity, and glucose/NO x . Stratifying for sex, again three factors were retained; however, in males NO x was loaded in two factors. In conclusion, serum NO x was associated and loaded with other MetS components in cluster analysis of metabolic risk factors.

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Abbreviations

ATPIII:

Adult Treatment Panel III

BP:

Blood pressure

CI:

Confidence interval

CVD:

Cardiovascular disease

DBP:

Diastolic blood pressure

eNOS:

Endothelial nitric oxide synthase

FPG:

Fasting plasma glucose

HDL-C:

High-density lipoprotein cholesterol

iNOS:

Inducible nitric oxide synthase

MetS:

Metabolic syndrome

MONICA:

Monitoring of trends and determinants in cardiovascular disease

mRNA:

Messenger ribonucleic acid

MSA:

Measure of sampling adequacy

NO:

Nitric oxide

NO x :

Nitric oxide metabolites

SBP:

Systolic blood pressure

TC:

Total cholesterol

TG:

Triglycerides

TLGS:

Tehran Lipid and Glucose Study

WC:

Waist circumference

WHO:

World Health Organization

WHR:

Waist-to-hip ratio

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Acknowledgments

This work was supported by a grant (No. 177) from the Research Institute for Endocrine Sciences of Shahid Beheshti University of Medical Sciences. The authors wish to thank Ms N. Shiva for her linguistic editing, Ms V. Khorasani for her technical assistance, and Ms P. Sarbakhsh for her statistical help.

Conflict of interest statement

The authors have no conflict of interest.

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Authors and Affiliations

  1. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box 19395-4763, Tehran, Iran

    Asghar Ghasemi, Saleh Zahediasl & Fereidoun Azizi

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  1. Asghar Ghasemi
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Correspondence to Saleh Zahediasl.

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Ghasemi, A., Zahediasl, S. & Azizi, F. Nitric oxide and clustering of metabolic syndrome components in pediatrics. Eur J Epidemiol 25, 45–53 (2010). https://doi.org/10.1007/s10654-009-9382-3

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