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Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis

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Abstract

The main cancer susceptibility syndromes that involve gynecologic cancers include Breast-Ovarian Cancer Syndrome and Lynch Syndrome/Hereditary Non-polyposis Colorectal Cancer Syndrome. For uterine cancer, approximately 5% of all cases are likely due to a hereditary cause and for ovarian cancer, approximately 10% are due to an inherited cause. Gynecologic oncologists play an important role in identifying women with ovarian or endometrial cancer who may have these syndromes. Personal and family history of relevant cancers assists with identification. For those women without cancer who are found to have a hereditary cancer syndrome, effective counseling in the prevention and early detection of cancers is crucial.

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Authors and Affiliations

  1. Department of Gynecologic Oncology, Clinical Cancer Genetics, U.T. M.D. Anderson Cancer Center, 11455 Herman Pressler St., Unit 1362, Houston, TX, 77030, USA

    Karen H. Lu

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  1. Karen H. Lu
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Correspondence to Karen H. Lu.

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Lu, K.H. Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis. Familial Cancer 7, 53–58 (2008). https://doi.org/10.1007/s10689-007-9144-x

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  • DOI: https://doi.org/10.1007/s10689-007-9144-x

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