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Implementing Large-Scale ENU Mutagenesis Screens in North America

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Abstract

A step towards annotating the mouse genome is to use forward genetics in phenotype-driven screens to saturate the genome with mutations. The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening.

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Authors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, TX, USA

    Amander T. Clark

  2. Tennessee Mouse Genome Center, TN, USA

    Daniel Goldowitz

  3. Center for Functional Genomics, Northwestern University, IL, USA

    Joseph S. Takahashi, Martha Hotz Vitaterna & Sandra M. Siepka

  4. Center for Mouse Models of Heart, Lung, Blood and Sleep Disorders, The Jackson Laboratory, ME, USA

    Luanne L. Peters

  5. Neuroscience Mutagenesis Facility, The Jackson Laboratory, ME, USA

    Wayne N. Frankel

  6. McLaughlin Research Institute for Biomedical Sciences, MT, USA

    George A. Carlson

  7. The Center for Modeling Human Disease, Canada

    Janet Rossant

  8. Case Western Reserve University/University Hospitals of Cleveland, OH, USA

    Joseph H. Nadeau

  9. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, TX, USA

    Monica J. Justice

Authors
  1. Amander T. Clark
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  2. Daniel Goldowitz
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  3. Joseph S. Takahashi
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  4. Martha Hotz Vitaterna
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  5. Sandra M. Siepka
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  6. Luanne L. Peters
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  7. Wayne N. Frankel
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  8. George A. Carlson
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  9. Janet Rossant
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  10. Joseph H. Nadeau
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  11. Monica J. Justice
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Clark, A.T., Goldowitz, D., Takahashi, J.S. et al. Implementing Large-Scale ENU Mutagenesis Screens in North America. Genetica 122, 51–64 (2004). https://doi.org/10.1007/s10709-004-1436-6

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  • DOI: https://doi.org/10.1007/s10709-004-1436-6

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