Skip to main content

Advertisement

SpringerLink
Log in

Pathology of Vogt–Koyanagi–Harada disease

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Typical histopathologic features of Vogt–Koyanagi–Harada disease (VKH) include granulomatous panuveitis with preservation of the choriocapillaris and exudative retinal detachment. In the chronic stage of the disease, however, histologic changes consist of nongranulomatous uveitis followed, in the chronic recurrent stage, by granulomatous uveitis and involvement of the choriocapillaris. In chronic VKH the peripheral fundus scars are not Dalén–Fuchs nodules; they are, instead, indicative of focal chorioretinal atrophy with loss of retinal pigment epithelium.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Inomata H, Rao NA (2001) Depigmented atrophic lesions in sunset glow fundi of Vogt–Koyangi–Harada disease. Am J Ophthalmol 131:607–614

    Article  PubMed  CAS  Google Scholar 

  2. Rao NA, Xu S, Font RL (1985) Sympathetic Ophthalmia. An immunohistochemical study of epithelioid and giant cells. Ophthalmology 92:1660–1662

    PubMed  CAS  Google Scholar 

  3. Font RL, Fine BS, Messmer E, Rawley JF (1983) Light and electron microscopic study of Dalén–Fuchs nodules in sympathetic ophthalmia. Ophthalmology 90:66–75

    PubMed  CAS  Google Scholar 

  4. Jakobiec FA, Marboe CC, Knowles DM II, Iwamoto T, Harrison W, Chang S, et al (1983) Human sympathetic ophthalmia. An analysis of the inflammatory infiltrate by hybridoma-monoclonal antibodies, immunochemistry, and correlative electron microscopy. Ophthalmology 90:76–95

    PubMed  CAS  Google Scholar 

  5. Sakamoto T, Murata T, Inomata H (1991) Class II major histocompatibility complex on melanocytes of Vogt–Koyanagi–Harada disease. Arch Ophthalmol 109:1270–1274

    PubMed  CAS  Google Scholar 

  6. Inomata H, Sakamoto T (1990) Immunohistochemical studies of Vogt–Koyanagi–Harada disease with sunset sky fundus. Curr Eye Res 9(Suppl):35–40

    PubMed  Google Scholar 

  7. Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S (2000) Tyrosinase family proteins are antigen specific to Vogt–Koyanagi–Harada disease. J Immunol 165:7323–9

    PubMed  CAS  Google Scholar 

  8. Moorthy RS, Inomata H, Rao NA (1995) Vogt–Koyanagi–Harada syndrome. Surv Ophthalmol 39:265–292

    Article  PubMed  CAS  Google Scholar 

  9. Perry HD, Font RL (1977) Clinical and histopathologic observations in severe Vogt–Koyanagi–Harada syndrome. Am J Ophthalmol 83:242–254

    PubMed  CAS  Google Scholar 

Download references

Acknowledgement

Supported in part by NEI core grant EY0 13040 and by a grant from Research to Prevent Blindness, New York, New York.

Author information

Authors and Affiliations

  1. Doheny Eye Institute, 1450 San Pablo St., DVRC 211, Los Angeles, CA, 90033, USA

    Narsing A. Rao

Authors
  1. Narsing A. Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Narsing A. Rao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rao, N.A. Pathology of Vogt–Koyanagi–Harada disease. Int Ophthalmol 27, 81–85 (2007). https://doi.org/10.1007/s10792-006-9029-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-006-9029-2

Keywords

Search

Navigation