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Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism

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Abstract

Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnized) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism.

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Authors and Affiliations

  1. Cognitive Neuroscience Laboratory, Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, 500 Preston Street, Bldg. A, Suite 210, Louisville, KY, 40292, USA

    Estate M. Sokhadze & Joshua Baruth

  2. Department of Bioengineering, University of Louisville, Louisville, KY, USA

    Ayman El-Baz

  3. Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, 500 Preston Street, Bldg. A, Suite 210, Louisville, KY, 40292, USA

    Ayman El-Baz & Manuel F. Casanova

  4. Department of Pediatrics, University of Louisville, Louisville, KY, USA

    Grace Mathai & Lonnie Sears

  5. Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, USA

    Joshua Baruth & Manuel F. Casanova

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  1. Estate M. Sokhadze
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Sokhadze, E.M., El-Baz, A., Baruth, J. et al. Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism. J Autism Dev Disord 39, 619–634 (2009). https://doi.org/10.1007/s10803-008-0662-7

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