Abstract
We consider a mathematical model of mesoscopic human cortical ictal electrical activity. We compare the model results with ictal electrocortical data recorded from three human subjects and show how the two agree. We determine that, in the model system, seizures result from increased connectivity between excitatory and inhibitory cell populations, or from decreased connectivity within either excitatory or inhibitory cell populations. We compare the model results with the disinhibition and 4-AP models of epilepsy and suggest how the model may guide the development of new anticonvulsant therapies.
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Kramer, M.A., Szeri, A.J., Sleigh, J.W. et al. Mechanisms of seizure propagation in a cortical model. J Comput Neurosci 22, 63–80 (2007). https://doi.org/10.1007/s10827-006-9508-5
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DOI: https://doi.org/10.1007/s10827-006-9508-5