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PEGylated synthetic surfactant vesicles (Niosomes): novel carriers for oligonucleotides

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Abstract

Polyethylene glycol (PEG) modified cationic niosomes were used to improve the stability and cellular delivery of oligonucleotides (OND). PEGylated cationic niosomes, composed of DC-Chol, PEG2000-DSPE and the non-ionic surfactant-Span®, offer some advantages as gene carriers. Complexes of PEGylated cationic niosomes and OND showed a neutral zeta potential with particle size about 300 nm. PEG-modification significantly decreased the binding of serum protein and prevented particle aggregation in serum. The loaded nuclear acid drug exhibited increased resistance to serum nuclease. Compared with cationic niosomes, the PEGylated niosomes showed a higher efficiency of OND cellular uptake in serum. Therefore, in terms of their stable physiochemical properties in storage and physiological environment, as well as low-cost and widely available materials, PEGylated cationic niosomes are promising drug delivery systems for improved OND potency in vivo.

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Acknowledgements

This work was supported by, the National Natural Science Foundation of China (NO. 30371692). We highly appreciate the kind help of Dr. Allan David (College of Pharmacy, The University of Michigan at Ann Arbor) in preparing this English manuscript.

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Authors and Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou, 310058, P.R. China

    Yongzhuo Huang, Jinliang Chen, Xiaojin Chen, Jianqing Gao & Wenquan Liang

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  1. Yongzhuo Huang
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  2. Jinliang Chen
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  3. Xiaojin Chen
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Correspondence to Wenquan Liang.

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Huang, Y., Chen, J., Chen, X. et al. PEGylated synthetic surfactant vesicles (Niosomes): novel carriers for oligonucleotides. J Mater Sci: Mater Med 19, 607–614 (2008). https://doi.org/10.1007/s10856-007-3193-4

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  • DOI: https://doi.org/10.1007/s10856-007-3193-4

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