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Synthesis and characterization of collagen/hydroxyapatite: magnetite composite material for bone cancer treatment

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Abstract

Our purpose was obtaining and characterizing a complex composite system with multifunctional role: bone graft material and hyperthermia generator necessary for bone cancer therapy. The designed system was a magnetite enriched collagen/hydroxyapatite composite material, obtained by a co-precipitation method. Due to the applied electromagnetic field the magnetite will induce hyperthermia and cause tumoral cell apoptosis. The complex bone graft system was characterised by XRD, FTIR and SEM, while the hyperthermia was quantify by measuring the temperature increase due to the applied alternative electromagnetical field.

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Acknowledgements

We are gratefully thanks to Chem. Madalina ALBU to provide us the collagen gel. This work was partially supported by Romanian National Authority for Scientific Research through project 72_198/2008.

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Authors and Affiliations

  1. Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 1-7 Polizu Street, 011061, Bucharest, Romania

    Ecaterina Andronescu, Maria Ficai, Georgeta Voicu, Denisa Ficai & Anton Ficai

  2. Center of Organic Chemistry “Costin D. Nenitescu”, Romanian Academy, 202B Splaiul Independentei, 050461, Bucharest, Romania

    Maria Maganu

Authors
  1. Ecaterina Andronescu
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  2. Maria Ficai
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  3. Georgeta Voicu
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  4. Denisa Ficai
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  5. Maria Maganu
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  6. Anton Ficai
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Correspondence to Anton Ficai.

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Andronescu, E., Ficai, M., Voicu, G. et al. Synthesis and characterization of collagen/hydroxyapatite: magnetite composite material for bone cancer treatment. J Mater Sci: Mater Med 21, 2237–2242 (2010). https://doi.org/10.1007/s10856-010-4076-7

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  • DOI: https://doi.org/10.1007/s10856-010-4076-7

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