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A Systematic Review of HIV/AIDS Survival and Delayed Diagnosis Among Hispanics in the United States

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Abstract

HIV/AIDS disproportionately affects Hispanics. Our objective was to determine the risk of late diagnosis and rate of survival after HIV/AIDS diagnosis among Hispanics compared to other racial/ethnic groups. We performed a systematic review of the PubMed database for peer-reviewed articles published between January 2000 and September 2010. Primary outcomes included survival after HIV/AIDS diagnosis and delayed diagnoses. The definition of delayed diagnosis varied by study, ranging from concurrent HIV/AIDS diagnosis to diagnosis of AIDS within 3 years of HIV diagnosis. We found that Hispanics are at significantly greater risk for delayed diagnosis than non-Hispanic whites. Hispanic males and foreign-born Hispanics had the highest risk of late diagnosis. Available data on survival were heterogeneous, with better outcomes in some Hispanic subgroups than in others. Survival after antiretroviral initiation was similar between Hispanics and Whites. These findings emphasize the need for culturally-sensitive strategies to promote timely diagnosis of HIV infection among Hispanics and to examine the health outcomes and needs of high risk Hispanic subgroups.

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References

  1. HIV/AIDS among Hispanics—United States, 2001–2005. MMWR Morb Mortal Wkly Rep. 2007 Oct 12;56(40):1052–1057.

    Google Scholar 

  2. Estimated Lifetime Risk for Diagnosis of HIV Infection Among Hispanics/Latinos—37 States and Puerto Rico, 2007 MMWR Morb Mortal Wkly Rep. 2010 Oct 15;59(40):1297–1301.

  3. US Census Bureau. Minority population tops 100 million. US Census Bureau News http://wwwcensusgov/newsroom/releases/archives/population/cb07-70html. Updated 17 May 2007. Accessed 2 Nov 2008.

  4. Alvarez ME, Jakhmola P, Painter TM, Taillepierre JD, Romaguera RA, Herbst JH, et al. Summary of comments and recommendations from the CDC consultation on the HIV/AIDS Epidemic and prevention in the Hispanic/Latino community. AIDS Educ Prev. 2009;21(5 Suppl):7–18.

    Article  PubMed  Google Scholar 

  5. Stallworth JM, Andia JF, Burgess R, Alvarez ME, Collins C. Diffusion of effective behavioral interventions and Hispanic/Latino populations. AIDS Educ Prev. 2009;21(5 Suppl):152–63.

    Article  PubMed  Google Scholar 

  6. Centers for Disease Control and Prevention. Deaths, percent of total deaths, and death rates for the 15 leading causes of death in 10-year age groups by Hispanic origin, race for non-Hispanic population, and sex: United States, 1999–2006. National Vital Statistics System 2006. http://www.cdc.gov/nchs/data/dvs/LCWK5_2006.pdf. Accessed 2 August 2010.

  7. Centers for Disease Control and Prevention. HIV Surveillance Report, 2008 vol. 20. http://www.cdc.gov/hiv/topics/surveillance/resources/reports/ Published June 2010. Accessed 30 July 2010.

  8. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.

    Article  PubMed  Google Scholar 

  9. Althoff KN, Gange SJ, Klein MB, Brooks JT, Hogg RS, Bosch RJ, et al. Late presentation for human immunodeficiency virus care in the United States and Canada. Clin Infect Dis. 2010;50(11):1512–20.

    Article  PubMed  Google Scholar 

  10. Carabin H, Keesee MS, Machado LJ, Brittingham T, Williams L, Sonleitner NK, et al. Estimation of the prevalence of AIDS, opportunistic infections, and standard of care among patients with HIV/AIDS receiving care along the U.S.-Mexico border through the Special Projects of National Significance: a cross-sectional study. AIDS Patient Care STDS. 2008;22(11):887–95.

    Article  PubMed  Google Scholar 

  11. Espinoza L, Hall HI, Hardnett F, Selik RM, Ling Q, Lee LM. Characteristics of persons with heterosexually acquired HIV infection, United States 1999–2004. Am J Public Health. 2007;97(1):144–9.

    Article  PubMed  Google Scholar 

  12. Espinoza L, Hall HI, Hu X. Increases in HIV diagnoses at the U.S.-Mexico border, 2003–2006. AIDS Educ Prev. 2009;21(5 Suppl):19–33.

    Article  PubMed  Google Scholar 

  13. Espinoza L, Hall HI, Selik RM, Hu X. Characteristics of HIV infection among Hispanics, United States 2003–2006. J Acquir Immune Defic Syndr. 2008;49(1):94–101.

    Article  PubMed  Google Scholar 

  14. Giordano TP, Bartsch G, Zhang Y, Tedaldi E, Absalon J, Mannheimer S, et al. Disparities in outcomes for African American and Latino subjects in the flexible initial retrovirus suppressive therapies (FIRST) trial. AIDS Patient Care STDS. 2010;24(5):287–95.

    Article  PubMed  Google Scholar 

  15. Hall HI, Byers RH, Ling Q, Espinoza L. Racial/ethnic and age disparities in HIV prevalence and disease progression among men who have sex with men in the United States. Am J Public Health. 2007;97(6):1060–6.

    Article  PubMed  Google Scholar 

  16. Hall HI, Geduld J, Boulos D, Rhodes P, An Q, Mastro TD et al. Epidemiology of HIV in the United States and Canada: current status and ongoing challenges. J Acquir Immune Defic Syndr (1999). 2009;51 Suppl 1(Journal Article):S13–20.

    Google Scholar 

  17. Hall HI, McDavid K, Ling Q, Sloggett A. Determinants of progression to AIDS or death after HIV diagnosis, United States, 1996 to 2001. Ann Epidemiol. 2006;16(11):824–33.

    Article  PubMed  Google Scholar 

  18. Kelley CF, Hernandez-Ramos I, Franco-Paredes C, del Rio C. Clinical, epidemiologic characteristics of foreign-born Latinos with HIV/AIDS at an urban HIV clinic. AIDS Reader. 2007;17(2):73–4.

    Google Scholar 

  19. Levy V, Prentiss D, Balmas G, Chen S, Israelski D, Katzenstein D, et al. Factors in the delayed HIV presentation of immigrants in Northern California: implications for voluntary counseling and testing programs. J Immigr Minor Health/Center for Minority Public Health. 2007;9(1):49–54.

    Article  Google Scholar 

  20. Schwarcz S, Weinstock H, Louie B, Kellogg T, Douglas J, Lalota M, et al. Characteristics of persons with recently acquired HIV infection: application of the serologic testing algorithm for recent HIV seroconversion in 10 US cities. J Acquir Immune Defic Syndr. 2007;44(1):112–5.

    Article  PubMed  Google Scholar 

  21. Torrone EA, Thomas JC, Leone PA, Hightow-Weidman LB. Late diagnosis of HIV in young men in North Carolina. Sex Transm Dis. 2007;34(11):846–8.

    Article  PubMed  Google Scholar 

  22. Wohl AR, Tejero J, Frye DM. Factors associated with late HIV testing for Latinos diagnosed with AIDS in Los Angeles. AIDS Care. 2009;21(9):1203–10.

    Article  PubMed  Google Scholar 

  23. Yang B, Chan SK, Mohammad N, Meyer JA, Risser J, Chronister KJ, et al. Late HIV diagnosis in Houston/Harris County, Texas, 2000–2007. AIDS Care. 2010;22(6):766–74.

    Article  PubMed  Google Scholar 

  24. Anastos K, Schneider MF, Gange SJ, Minkoff H, Greenblatt RM, Feldman J, et al. The association of race, sociodemographic, and behavioral characteristics with response to highly active antiretroviral therapy in women. J Acquir Immune Defic Syndr (1999). 2005;39(5):537–44.

    CAS  Google Scholar 

  25. Arnold M, Hsu L, Pipkin S, McFarland W, Rutherford GW. Race, place and AIDS: the role of socioeconomic context on racial disparities in treatment and survival in San Francisco. Soc Sci Med. 2009;69(1):121–8.

    Article  PubMed  Google Scholar 

  26. Hanna DB, Pfeiffer MR, Torian LV, Sackoff JE. Concurrent HIV/AIDS diagnosis increases the risk of short-term HIV-related death among persons newly diagnosed with AIDS, 2002–2005. AIDS Patient Care STDs. 2008;22(1):17–28.

    Article  PubMed  Google Scholar 

  27. Harrison KM, Song R, Zhang X. Life expectancy after HIV diagnosis based on National HIV surveillance data from 25 States, United States. J Acquir Immune Defic Syndr. 2010;53(1):124–30.

    Article  PubMed  Google Scholar 

  28. Losina E, Schackman BR, Sadownik SN, Gebo KA, Walensky RP, Chiosi JJ, et al. Racial and sex disparities in life expectancy losses among HIV-infected persons in the United States: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapy. Clin Infect Dis. 2009;49(10):1570–8.

    Article  PubMed  Google Scholar 

  29. McGinnis KA, Fine MJ, Sharma RK, Skanderson M, Wagner JH, Rodriguez-Barradas MC, et al. Understanding racial disparities in HIV using data from the veterans aging cohort 3-site study and VA administrative data. Am J Public Health. 2003;93(10):1728–33.

    Article  PubMed  Google Scholar 

  30. Nash D, Katyal M, Shah S. Trends in predictors of death due to HIV-related causes among persons living with AIDS in New York City: 1993–2001. J Urban Health. 2005;82(4):584–600.

    Article  PubMed  Google Scholar 

  31. Sackoff JE, Hanna DB, Pfeiffer MR, Torian LV. Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med. 2006;145(6):397–406.

    PubMed  Google Scholar 

  32. Silverberg MJ, Leyden W, Quesenberry CP Jr, Horberg MA. Race/ethnicity and risk of AIDS and death among HIV-infected patients with access to care. J Gen Intern Med. 2009;24(9):1065–72.

    Article  PubMed  Google Scholar 

  33. Woldemichael G, Christiansen D, Thomas S, Benbow N. Demographic characteristics and survival with AIDS: health disparities in Chicago, 1993–2001. Am J Public Health. 2009;99(Suppl 1):S118–23.

    Article  PubMed  Google Scholar 

  34. Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, et al. Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009;360(18):1815–26.

    Article  PubMed  CAS  Google Scholar 

  35. Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, Harris R, et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009;373(9672):1352–63.

    Article  PubMed  Google Scholar 

  36. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. December 1, 2009; 1–161. Available at http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed 20 Oct 2010.

  37. Livingston G, Minushkin S, Cohn D. Hispanics and Health Care in the United States: access, information and knowledge. A Joint Pew Hispanic Center and Robert Wood Johnson Foundation Research Report. 2008; Available at http://pewhispanic.org/files/reports/91.pdf. Accessed 20 Oct 2010.

  38. Lara M, Gamboa C, Kahramanian MI, Morales LS, Bautista DE. Acculturation and Latino health in the United States: a review of the literature and its sociopolitical context. Annu Rev Public Health. 2005;26:367–97.

    Article  PubMed  Google Scholar 

  39. Ransford HE, Carrillo FR, Rivera Y. Health care-seeking among Latino immigrants: blocked access, use of traditional medicine, and the role of religion. J Health Care Poor Underserved. 2010;21(3):862–78.

    Article  PubMed  Google Scholar 

  40. DuBard CA, Gizlice Z. Language spoken and differences in health status, access to care, and receipt of preventive services among US Hispanics. Am J Public Health. 2008;98(11):2021–8.

    Article  PubMed  Google Scholar 

  41. Smith DP, Bradshaw BS. Rethinking the Hispanic paradox: death rates and life expectancy for US non-Hispanic White and Hispanic populations. Am J Public Health. 2006;96(9):1686–92.

    Article  PubMed  Google Scholar 

  42. Swallen KC, West DW, Stewart SL, Glaser SL, Horn-Ross PL. Predictors of misclassification of Hispanic ethnicity in a population-based cancer registry. Ann Epidemiol. 1997;7(3):200–6.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Dr. Page was supported by a K23 career development award (K23HD056957) from the National Institute of Allergy and Infectious Diseases (NIAID) and National Institutes of Health (NIH).

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Correspondence to Nadine E. Chen.

Appendices

Appendix 1

“Hispanic Americans”[MeSH Terms] OR “Hispanic Americans”[All Fields] OR “Hispanic”[All Fields] OR “Hispanics”[All Fields] OR “latina”[All Fields] OR “Latinas”[All Fields] OR “Hispanic”[All Fields] OR “Hispanics”[All Fields] OR “Hispanic American”[All Fields] OR “Mexican–American”[All Fields] OR “Mexican Americans”[MeSH Terms] OR “Mexican Americans”[All Fields] OR “Puerto Rican”[All Fields] OR “Puerto Ricans”[All Fields] OR “Spanish American”[All Fields] OR “Spanish Americans”[All Fields] OR “Cuban American”[All Fields] OR “Cuban Americans”[All Fields] OR “Spanish speaking”[All Fields].

AND

“Hiv”[MeSH Terms] OR “HIV”[All Fields] OR “Human Immunodeficiency Virus”[All Fields] OR “Human Immunodeficiency Viruses”[All Fields] OR “AIDS virus”[All Fields] OR “AIDS viruses”[All Fields] OR “HTLV-III”[All Fields] OR “Human T Cell Lymphotropic Virus Type III”[All Fields] OR “Human T Lymphotropic Virus Type III”[All Fields] OR “Human T-Cell Leukemia Virus Type III”[All Fields] OR “Human T Cell Leukemia Virus Type III”[All Fields] OR “Human T-Cell Lymphotropic Virus Type III”[All Fields] OR “Human T-Lymphotropic Virus Type III”[All Fields] OR “LAV-HTLV-III”[All Fields] OR “Lymphadenopathy-Associated Virus”[All Fields] OR “Lymphadenopathy Associated Virus”[All Fields] OR “Acquired Immune Deficiency Syndrome Virus”[All Fields] OR “Acquired Immunodeficiency Syndrome Virus”[All Fields] OR “Immune Reconstitution Inflammatory Syndrome”[mesh] OR “immune reconstitution inflammatory syndrome”[All Fields] OR “immune reconstitution”[All Fields] OR “immune restoration”[All Fields] OR “viral suppression”[All Fields] OR “viral load”[mesh] OR “viral load”[All Fields] OR “viral burden”[All Fields] OR “virus titer”[All Fields] OR “CD4 Lymphocyte Count”[mesh] OR “CD4 Lymphocyte Count”[All Fields] OR “CD4 Lymphocyte Counts”[All Fields] OR “CD4 Counts”[All Fields] OR “CD4 count”[All Fields] OR “CD4 cell count”[All Fields] OR “CD4 cell counts”[All Fields] OR “T4 lymphocyte count”[All Fields] OR “T4 lymphocyte counts”[All Fields] OR “CD4-Positive T-Lymphocytes”[mesh] OR “CD4-Positive T-Lymphocytes”[All Fields] OR “CD4 Positive T Lymphocytes”[All Fields] OR “CD4-Positive T-Lymphocyte”[All Fields] OR “T4 cell”[All Fields] OR “T4 cells”[All Fields] OR “T4 lymphocytes”[All Fields] OR “T4 lymphocyte”[All Fields] OR “CD4 positive lymphocyte”[All Fields] OR “CD4 positive lymphocytes”[All Fields].

AND

“treatment outcome”[mesh] OR “treatment outcome”[All Fields] OR “treatment failure”[mesh] OR “treatment failure”[All Fields] OR “treatment failures”[All Fields] OR “prognosis”[MeSH] OR “prognosis”[All Fields] OR “prognoses”[All Fields] OR “disease free survival”[mesh] OR “disease free survival”[All Fields] OR “medical futility”[mesh] OR “medical futility”[All Fields] OR “nomograms”[mesh] OR “nomograms”[All Fields] OR “mortality”[subheading] OR “mortality”[MeSH] OR “mortality”[All Fields] OR “mortalities”[All Fields] OR “cause of death”[mesh] OR “cause of death”[All Fields] OR “fatal outcome”[mesh] OR “fatal outcome”[All Fields] OR “fatal outcomes”[All Fields] OR “fatality rate”[All Fields] OR “fatality rates”[All Fields] OR “fatality”[All Fields] OR “fatalities”[All Fields] OR “death rate”[All Fields] OR “death rates”[All Fields] OR “death”[All Fields] OR “deaths”[All Fields] OR “survival rate”[mesh] OR “survival rate”[All Fields] OR “epidemiology”[Subheading] OR “epidemiology”[All Fields] OR “morbidity”[All Fields] OR “morbidity”[MeSH Terms] OR “morbidity”[All Fields] OR “morbidities”[All Fields] OR “survival”[All Fields] OR “Late presentation”[All Fields] OR “access to care”[All Fields] OR “health services accessibility”[mesh] OR “health services accessibility”[All Fields] OR “availability of health services”[All Fields] OR “health services availability”[All Fields] OR “accessibility of health services”[All Fields] OR “program accessibility”[All Fields] OR “risk perception”[All Fields] OR “perception of risk”[All Fields] OR “perception”[mesh] OR “delayed diagnosis”[mesh] OR “delayed diagnosis”[All Fields] OR “delayed diagnoses”[All Fields] OR “late diagnosis”[All Fields] OR “late diagnoses”[All Fields] OR “acculturation”[MeSH Terms] OR “acculturation”[All Fields] OR “cultural assimilation”[All Fields] OR “culturally sensitive”[All Fields] OR “cultural sensitivity”[All Fields] OR “stigma”[All Fields] OR “taboo”[mesh] OR “taboo”[All Fields] OR “taboos”[All Fields] OR “deportation”[All Fields] OR “prejudice”[mesh] OR “prejudice”[All Fields] OR “prejudices”[All Fields] OR “racism”[All Fields] OR “social discrimination”[All Fields] OR “segregation”[All Fields] OR “unrecognized infection”[All Fields] OR “Patient Compliance”[Mesh] OR “patient compliance”[All Fields] OR “patient noncompliance”[All Fields] OR “patient non compliance”[All Fields] OR “patient adherence”[All Fields] OR “patient nonadherence”[All Fields] OR “patient non adherence”[All Fields] OR “patient cooperation”[All Fields] OR “Medication Adherence”[Mesh] OR “medication adherence”[All Fields] OR “medication non adherence”[All Fields] OR “medication nonadherence”[All Fields] OR “medication compliance”[All Fields] OR “medication non compliance”[All Fields] OR “medication noncompliance”[All Fields] OR “medication persistence”[All Fields].

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Chen, N.E., Gallant, J.E. & Page, K.R. A Systematic Review of HIV/AIDS Survival and Delayed Diagnosis Among Hispanics in the United States. J Immigrant Minority Health 14, 65–81 (2012). https://doi.org/10.1007/s10903-011-9497-y

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