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The Relevance of Mouse Models to Understanding the Development and Progression of Human Breast Cancer

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events that mediate the initiation, development, and progression of breast cancer, and they offer new opportunities to develop and test strategies to treat and, perhaps, even prevent the disease. This chapter reviews the historical development of mouse models of breast cancer and highlights some of their major strengths, weaknesses, and contributions.

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Abbreviations

TDLUs:

terminal duct lobular units

CCH:

columnar cell hyperplasia

HELUs:

hyperplastic enlarged lobular units

ADH:

atypical ductal hyperplasia

DCIS:

ductal carcinoma in situ

IBC:

invasive breast cancer

ALH:

atypical lobular hyperplasia

LCIS:

lobular carcinoma in situ

ILC:

infiltrating lobular carcinoma

EMT:

epithelial-mesenchymal transition

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  1. Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St. Louis, MO, 63110, USA

    D. Craig Allred

  2. Department of Cellular and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Daniel Medina

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  1. D. Craig Allred
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  2. Daniel Medina
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Correspondence to D. Craig Allred.

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Allred, D.C., Medina, D. The Relevance of Mouse Models to Understanding the Development and Progression of Human Breast Cancer. J Mammary Gland Biol Neoplasia 13, 279–288 (2008). https://doi.org/10.1007/s10911-008-9093-5

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  • DOI: https://doi.org/10.1007/s10911-008-9093-5

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