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Oligodendroglial-specific Transcriptional Factor SOX10 is Ubiquitously Expressed in Human Gliomas

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Summary

The two most common types of gliomas: astrocytoma and oligodendroglioma are distinguished based on their morphologic similarities to mature astrocytes and oligodendroglia. Whereas prototypical examples of the tumors have distinct pathogenetic and prognostic differences, the majority of the gliomas falls in the intermediate category and their distinction is problematic. The transcriptional factor SOX10 is one of the key determinants of oligodendroglial differentiation. We applied immunohistochemistry to analyze whether the expression of SOX10 can differentiate astrocytoma and oligodendroglioma. The majority of oligodendrogliomas, but also a large fraction of astrocytomas, including the least differentiated glioblastomas, expressed SOX10, albeit at lower levels. Comparison with 1p and 19q deletion status by FISH analysis also revealed no obvious associations. High levels of expression were also found in pilocytic astrocytoma, consistent with recent studies suggesting that pilocytic astrocytomas have greater overlap with oligodendroglial than astrocytic tumors. Our data raise a possibility that histogenesis of gliomas have more common features than previously anticipated.

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Abbreviations

PA:

pilocytic astrocytoma

O:

oligodendroglioma

MOA:

mixed oligoastrocytoma

AO:

anaplastic oligodendroglioma

AOA:

anaplastic oligoastrocytoma

A:

astrocytoma

AA:

anaplastic astrocytoma

GBM:

glioblastoma multiforme

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Authors and Affiliations

  1. Department of Pathology, Yale University School of Medicine, New Haven, CT, USA

    Sergei I. Bannykh & Jung Kim

  2. Institut für Biochemie, Universität Erlangen, Erlangen, Germany

    C. Claus Stolt & Michael Wegner

  3. Division of Neuropathology, Washington University School of Medicine, St. Louis, Missouri, USA

    Arie Perry

Authors
  1. Sergei I. Bannykh
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  2. C. Claus Stolt
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  3. Jung Kim
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  4. Arie Perry
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  5. Michael Wegner
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Correspondence to Sergei I. Bannykh.

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Bannykh, S.I., Stolt, C.C., Kim, J. et al. Oligodendroglial-specific Transcriptional Factor SOX10 is Ubiquitously Expressed in Human Gliomas. J Neurooncol 76, 115–127 (2006). https://doi.org/10.1007/s11060-005-5533-x

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