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Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme

  • Clinical–Patient Studies
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Abstract

We aimed to evaluate the feasibility and tolerability of the newly developed thermotherapy using magnetic nanoparticles on recurrent glioblastoma multiforme. Fourteen patients received 3-dimensional image guided intratumoral injection of aminosilane coated iron oxide nanoparticles. The patients were then exposed to an alternating magnetic field to induce particle heating. The amount of fluid and the spatial distribution of the depots were planned in advance by means of a specially developed treatment planning software following magnetic resonance imaging (MRI). The actually achieved magnetic fluid distribution was measured by computed tomography (CT), which after matching to pre-operative MRI data enables the calculation of the expected heat distribution within the tumor in dependence of the magnetic field strength. Patients received 4–10 (median: 6) thermotherapy treatments following instillation of 0.1–0.7 ml (median: 0.2) of magnetic fluid per ml tumor volume and single fractions (2 Gy) of a radiotherapy series of 16–70 Gy (median: 30). Thermotherapy using magnetic nanoparticles was tolerated well by all patients with minor or no side effects. Median maximum intratumoral temperatures of 44.6°C (42.4–49.5°C) were measured and signs of local tumor control were observed. In conclusion, deep cranial thermotherapy using magnetic nanoparticles can be safely applied on glioblastoma multiforme patients.

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Acknowledgments

This work was supported by the EFRE Project “NanoMed”, Nanotechnology in Medicine, No. 2000-22006 2 ue/2. We thank Steven A. Toms (Brain Tumor Institute, Cleveland Clinic Foundation) for valuable suggestions during discussion of this manuscript.

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Authors and Affiliations

  1. Department of Neurosurgery, Bundeswehrkrankenhaus, Berlin, Germany

    Klaus Maier-Hauff & Ronny Rothe

  2. MagForce Nanotechnologies AG, Berlin, Germany

    Regina Scholz, Uwe Gneveckow, Norbert Waldoefner & Andreas Jordan

  3. Department of Radiation Medicine CVK, Charité-University Medicine, Berlin, Germany

    Peter Wust, Burghard Thiesen, Annelie Feussner & Roland Felix

  4. Department of Neuropathology, CVK, Charité-University Medicine, Berlin, Germany

    Andreas von Deimling

Authors
  1. Klaus Maier-Hauff
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  2. Ronny Rothe
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  3. Regina Scholz
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  4. Uwe Gneveckow
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  5. Peter Wust
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  11. Andreas Jordan
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Correspondence to Klaus Maier-Hauff.

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Disclosure statement:

Andreas Jordan is a manager and Regina Scholz, Uwe Gneveckow and Norbert Waldoefner are employees at MagForce Nanotechnologies AG, Berlin, Germany. The other authors declare that they do not have any affiliations that would lead to conflict of interest.

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Maier-Hauff, K., Rothe, R., Scholz, R. et al. Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme. J Neurooncol 81, 53–60 (2007). https://doi.org/10.1007/s11060-006-9195-0

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  • DOI: https://doi.org/10.1007/s11060-006-9195-0

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