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Treatment of recurrent glioblastoma: can local delivery of mitoxantrone improve survival?

  • Clinical-Patient Studies
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Abstract

In this study, the records of 276 adult patients with recurrent glioblastoma (GBM) treated at recurrence at our institution between 2004 and 2006 were reviewed for progression-free survival (PFS), overall survival (OS), and toxicity. At recurrence, all patients underwent systemic treatment with temozolomide (200 mg/sqm on days 1–5 every 28 days) until tumor progression. Patients, whose tumor was judged resectable without risk of adjunctive neurological deficit, underwent a second surgery with or without positioning of a Rickam/Ommaya reservoir. The reservoir was used for locoregional chemotherapy with mitoxantrone. Two hundred seventy-six rGBL patients (pts) were divided into three subgroups: A 161 pts treated only with temozolomide, B 50 pts re-operated-on +temozolomide, and C 65 pts re-operated on + temozolomide + locoregional CHT. For group A, the 6 month PFS and 6 month survival (ST) were 39.3 and 43%, respectively, with a median survival time (mST) of 5 months (range 4–6) and 25% of pts alive at 9 months. For group B, the 6 month PFS and 6 month survivors were 64 and 74.1%, respectively, with a mST of 8 months (range 6–10) and 25% of pts alive at 12 months. For group C, the 6 month PFS and 6 month survivors were 70.7 and 87.7%, respectively, with a mST of 11 months (range 9–13) and 25% of pts alive at 18 months (A vs. B vs. C, log-rank P < 0.001) (B vs. C, P = 0.041) (A vs. B P = 0.009). Cox proportional hazard model was used to obtain Hazard Ratio (HR) for type of treatment corrected by age and time (in months) between diagnosis and first recurrence: second tumor debulking was statistically effective for survival, reducing by 36% the risk of death (HR = 0.64; 0.46–0.89), but the most significant favorable prognostic factor for survival was the local delivery of mitoxantrone which reduced the risk of death to 50% (HR = 0.50; 0.38–0.68).

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Authors and Affiliations

  1. Department of Neuro-oncology, Fondazione IRCSS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    Amerigo Boiardi, Antonio Silvani, Marica Eoli, Elena Lamperti, Andrea Salmaggi, Paola Gaviani, Anna Fiumani & Andrea Botturi

  2. Unit of Neuro-epidemiology, Fondazione IRCSS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    Chiara Falcone, Alessandra Solari & Graziella Filippini

  3. Department of Neurosurgery, Fondazione IRCSS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy

    Francesco Di Meco & Giovanni Broggi

Authors
  1. Amerigo Boiardi
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  2. Antonio Silvani
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  3. Marica Eoli
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Correspondence to Amerigo Boiardi.

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Boiardi, A., Silvani, A., Eoli, M. et al. Treatment of recurrent glioblastoma: can local delivery of mitoxantrone improve survival?. J Neurooncol 88, 105–113 (2008). https://doi.org/10.1007/s11060-008-9540-6

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  • DOI: https://doi.org/10.1007/s11060-008-9540-6

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