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Assessment of quality of life among HIV-infected persons in Pune, India

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Abstract

Objective: To study dimensions of Quality of Life (QOL) amongst HIV infected persons, their relationship with socio-demographic characteristics and disease progression.

Design: Cross-sectional study with one time assessment of QOL.

Methods: Modified Medical Outcome Study (MOS) core instrument [The Medical Outcome Study 116 core set of Measures of functioning and well being, Appendix A, core survey instrument (internet)] was interview -administered to 100 HIV infected individuals.

Results: The instrument showed significant positive inter-domain correlations and desired linear association between QOL scores and the CD4 counts. The scale had a Cronbach α value of 0.75. QOL was markedly affected in the domains of physical health, work and earnings, routine activities and appetite and food intake. Women had significantly lower QOL scores than men despite having less advanced disease. The QOL scores were significantly lower among persons with lower CD4 counts mainly in different domains of physical health.

Conclusions: The modified MOS scale had the desired reliability and validity for evaluation of QOL in the HIV-infected persons in India. Low scores in the domains of physical health compared to other domains suggest a strategy to focus on medical intervention. A need for psychosocial intervention for women was perceived. Longitudinal studies must be done to assess the impact of anti-retroviral therapy being rolled out through the national programme on QOL.

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References

  1. The Medical Outcome Study 116 core set of measures of functioning and well being, Appendix A, Core survey instrument (Internet).

  2. S Low-Beers K Chan E Wood et al. (2000) ArticleTitleHealth related quality of life among persons with HIV after the use of protease inhibitors Qual Life Res 8 941–949 Occurrence Handle10.1023/A:1008985728271

    Article  Google Scholar 

  3. A. Wu (2000) ArticleTitleQuality of life assessment comes of age in the era of highly active antiretroviral therapy AIDS 14 1449–1451 Occurrence Handle1:STN:280:DC%2BD3M%2FlsFSjtg%3D%3D Occurrence Handle10930161

    CAS  PubMed  Google Scholar 

  4. JA Scott-Lennox RJ Mills MS. Burt (1998) ArticleTitleImpact of Zidovudin plus lamivudin or Zalcitabine on health related quality of life Ann Pharmacother 32 525–530 Occurrence Handle10.1345/aph.17311 Occurrence Handle1:CAS:528:DyaK1cXjsVOksrk%3D Occurrence Handle9606471

    Article  CAS  PubMed  Google Scholar 

  5. DA Revicki G Moyle H Stellbrink et al. (1999) ArticleTitleQuality of life outcomes of combination Zalcitabine–Zidovudin, Sequinavir–Zidovudin, and Sequinavir–Zalcitabine–Zidovudin therapy for HIV-infected adults with CD4 cell counts between 50 and 350 per cubic millimetre AIDS 13 851–858 Occurrence Handle1:CAS:528:DyaK1MXjsFejsr4%3D Occurrence Handle10357386

    CAS  PubMed  Google Scholar 

  6. C Cohen DA Revicki A Nabulsi et al. (1998) ArticleTitleA randomised trial of the effect of ritonavir in maintaining quality of life in advanced HIV disease AIDS 12 495–502 Occurrence Handle10.1097/00002030-199805000-00011 Occurrence Handle1:STN:280:DyaK1c3gt1Cmsg%3D%3D Occurrence Handle9543448

    Article  CAS  PubMed  Google Scholar 

  7. NI Paton CA Chapman SP Chan et al. (2002) ArticleTitleValidation of the medical outcome study HIV (1), health survey as a measure of quality of life in HIV infected patients in Singapore Int J STD AIDS 13 456–461 Occurrence Handle10.1258/09564620260079608 Occurrence Handle12171664

    Article  PubMed  Google Scholar 

  8. DP Lubeck JF. Fries (1997) ArticleTitleAssessment of quality of life in early stage HIV-infected persons: Data from the AIDS Time – Oriented Health Outcome Study (ATHOS) Qual Life Res 6 494–506 Occurrence Handle1:STN:280:ByiH2s7mtV0%3D Occurrence Handle9330550

    CAS  PubMed  Google Scholar 

  9. LE Eriksson G Nordstron T Berglund et al. (2000) ArticleTitleThe health related quality of life in a Swedish sample of HIV infected persons J Adv Nurs 32 213–223 Occurrence Handle10.1046/j.1365-2648.2000.01592.x

    Article  Google Scholar 

  10. JE Cowdery JA. Pesa (2002) ArticleTitleAssessing quality of life in women living with HIV Infection AIDS Care 14 235–245 Occurrence Handle1:STN:280:DC%2BD383gs1yntg%3D%3D Occurrence Handle11940281

    CAS  PubMed  Google Scholar 

  11. RD Hays MF. Shapiro (1992) ArticleTitleAn overview of generic health related quality of life measures for HIV research Qual Life Res 1 91–98 Occurrence Handle10.1007/BF00439716 Occurrence Handle1:STN:280:ByyB2cvnt1I%3D Occurrence Handle1301123

    Article  CAS  PubMed  Google Scholar 

  12. The WHOQOL HIV Group. Initial steps to developing the World Health Organisation’s Quality of Life Instrument (WHOQOL) module for International assessment in HIV/AIDS, AIDS Care 2003; 15: 347–357.

  13. Brown L, Ruth L. Review of instruments assessing health related quality of life, excerpts from “A review of approaches and instruments for assessing health – Related quality of life” Tulane University /Horizon (Internet).

  14. D Franchi RP. Wenel (1998) ArticleTitleMeasuring health related quality of life among patients infected with human immunodeficiency virus Clin Infect Dis 26 20–26 Occurrence Handle1:STN:280:DyaK1c7hs1KrsQ%3D%3D Occurrence Handle9455505

    CAS  PubMed  Google Scholar 

  15. A Douaihy N. Singh (2001) ArticleTitleFactors affecting quality of life in patients with HIV infection AIDS Reader 11 444–449 Occurrence Handle11682917

    PubMed  Google Scholar 

  16. CDC. Revision of the case definition of acquired immuno-deficiency syndrome for national reporting. US MMWR 1985; 34: 373–375.

    Google Scholar 

  17. AH Miners CA Sabin A Mocroft et al. (2001) ArticleTitleHealth-related quality of life in individuals infected with HIV in the era of HAART HIV Clin Trials 2 484–492 Occurrence Handle1:STN:280:DC%2BD3MjgtV2ruw%3D%3D Occurrence Handle11742437

    CAS  PubMed  Google Scholar 

  18. P Carrieri B Spire S Duran et al. (2003) ArticleTitleHealth related quality of life after one year of highly active antiretroviral therapy J AIDS 32 38–47

    Google Scholar 

  19. AW Wu DL Jacobson KD Frick et al. (2002) ArticleTitleValidity and responsiveness of the EuroQol as a measure of health related Quality of life in people enrolled in an AIDS clinical trial Qual Life Res 11 273–282 Occurrence Handle1:STN:280:DC%2BD38zjtFGjsw%3D%3D Occurrence Handle12074264

    CAS  PubMed  Google Scholar 

  20. Huba GJ, Melchior LA. A report: Executive summary on Self perceived quality of life among HIV/AIDS patients in treatment within the Fort Lauderdale/Broward County Ryan White Title 1 Eligible Metropolitan Area. 2002. The measurement Group LLc, 5811A Uplander Way, Culver City, California 90230,888.864.4636. www.Themeasurement Group.com

  21. CJ Gill JL Grffith D Jacobson et al. (2002) ArticleTitleRelationship of HIV viral loads, CD4 counts, and HAART use to health related quality of life J AIDS 30 485–492

    Google Scholar 

  22. C Han CC Pulling SE Telke et al. (2002) ArticleTitleAssessing the utility of five domains in SF-12 health status questionnaire in an AIDS clinical trial AIDS 16 431–439 Occurrence Handle12396695

    PubMed  Google Scholar 

  23. MI Campsmith AK Nakashima AJ. Davidson (2003) ArticleTitleSelf reported health related quality of life in persons with HIV infection: Results from multi-sites interview project Health Qual Life Outcomes 1 12 Occurrence Handle12773200

    PubMed  Google Scholar 

  24. C Cedrerfjall A Langius-Eklof K Lidman et al. (2001) ArticleTitleGender differences in the perceived heath related quality of life among patients with HIV infection AIDS Patient Care STD 15 31–39 Occurrence Handle1:STN:280:DC%2BD3M3gtlSrsQ%3D%3D Occurrence Handle11177586

    CAS  PubMed  Google Scholar 

  25. KA McDonnell AC Gielen AW Wu et al. (2000) ArticleTitleMeasuring health related quality of life among women living with HIV Qual Life Res 9 931–940 Occurrence Handle1:STN:280:DC%2BD3M3ivVCgtQ%3D%3D Occurrence Handle11284212

    CAS  PubMed  Google Scholar 

  26. WR Landerking MA Testa D Katsenstein et al. (1997) ArticleTitleMeasuring quality of life in HIV early disease: The modular approach Qual Life Res 6 515–530 Occurrence Handle1:STN:280:ByiH2s7mtFU%3D Occurrence Handle9330552

    CAS  PubMed  Google Scholar 

  27. T Watchel J Piette V Mor et al. (1992) ArticleTitleQuality of life in persons with human immunodeficiency virus infection: Measurement by the medical outcome study instrument Ann Intern Med 116 129–137 Occurrence Handle1:STN:280:By2D1cfhvVQ%3D Occurrence Handle1727616

    CAS  PubMed  Google Scholar 

  28. MY Smith J Feldmen P Kelly et al. (1996) ArticleTitleHealth related quality of life of HIV infected women: Evidence for the reliability, validity and responsiveness of the medical outcomes study short form 20 Qual Life Res 5 47–55 Occurrence Handle10.1007/BF00435968 Occurrence Handle1:STN:280:ByiD2Mjgt1M%3D Occurrence Handle8901366

    Article  CAS  PubMed  Google Scholar 

  29. Phillips KD, Sowell RL, Rush C et al. Psychosocial and physiologic correlates of perceived health among HIV infected women. Southern Online J Nurs Res 2001; 2.

  30. F Starace L Cafaro N Abrescia et al. (2002) ArticleTitleQuality of life assessment in HIV positive persons: application & validation of WHOQOL-HIV, Italian version AIDS Care 14 405–415 Occurrence Handle1:STN:280:DC%2BD38zgtVyqsw%3D%3D Occurrence Handle12042086

    CAS  PubMed  Google Scholar 

  31. CD Borgo I Izzi F Chiarotti et al. (2001) ArticleTitleMultidimensional aspects of pain in HIV-infected individuals AIDS Patient Care STD 15 95–102

    Google Scholar 

  32. X Badia D Podzamczer M Garcia et al. (1999) ArticleTitlethe Spanish MOS-HIV and MQOL-HIV Validation Group. A randomised study comparing instruments for measuring health related quality of life in HIV-infected patients AIDS 13 1727–1735 Occurrence Handle1:STN:280:DyaK1Mvjslaktg%3D%3D Occurrence Handle10509575

    CAS  PubMed  Google Scholar 

  33. R Murri A Ammassari M Fantoni et al. (1997) ArticleTitleDisease related factors associated with health related quality of life in people with non-advanced HIV disease assessed using an Italian version of the MOS-HIV health Survey J AIDS 16 350–356 Occurrence Handle1:STN:280:DyaK1c%2FotVGjsA%3D%3D

    CAS  Google Scholar 

  34. AW Wu HR Rubin WC Mathews et al. (1991) ArticleTitleA health status questionnaire using 30 items from the medical outcomes study. Preliminary validation in persons with early HIV infection Med Care 29 786–798 Occurrence Handle1:STN:280:By6A2c3is1I%3D Occurrence Handle1875745

    CAS  PubMed  Google Scholar 

  35. JE Ware M Kosinski B Gandek et al. (1998) ArticleTitleThe factor structure of SF-36 health survey in 10 countries: Results from the IQOLA project J Clin Epidemiol 51 1159–1165 Occurrence Handle9817133

    PubMed  Google Scholar 

  36. AW Wu DA Revicki D Jacobson et al. (1997) ArticleTitleEvidence for reliability, validity and usefulness of the Medical Outcome Study HIV health survey (MOS-HIV) Qual Life Res 6 481–493 Occurrence Handle1:STN:280:ByiH2s7mtVw%3D Occurrence Handle9330549

    CAS  PubMed  Google Scholar 

  37. MA Chesney S. Folkman (1994) ArticleTitlePsychological impact of HIV disease and implications for intervention Psychiatr Clin North Am 17 163–182 Occurrence Handle1:STN:280:ByuB2cfgslA%3D Occurrence Handle8190663

    CAS  PubMed  Google Scholar 

  38. JA Nunes SJ Raymond PK Nicholas et al. (1995) ArticleTitleSocial support, quality of life, immune function and health in persons living with HIV J Holist Nurs 13 174–198 Occurrence Handle1:STN:280:ByqB28zps1w%3D Occurrence Handle7745242

    CAS  PubMed  Google Scholar 

  39. WE Cunningham MF Shapiro RD Hays et al. (1998) ArticleTitleConstitutional symptoms and health related quality of life of patients with symptomatic HIV disease Am J Med 104 129–136 Occurrence Handle1:STN:280:DyaK1c7oslGkuw%3D%3D Occurrence Handle9528730

    CAS  PubMed  Google Scholar 

  40. DR Globe RD Hays WE. Cunningham (1999) ArticleTitleAssociation of Clinical parameters with health related quality of life in hospitalised persons with HIV disease AIDS Care 11 71–86 Occurrence Handle1:STN:280:DyaK1MzmtlynsA%3D%3D Occurrence Handle10434984

    CAS  PubMed  Google Scholar 

  41. KP Weinfurt RJ Willke HA Glick et al. (2000) ArticleTitleRelationship between CD4 count, viral burden, and quality of life over time in HIV-1 infected patients Med Care 38 404–410 Occurrence Handle1:STN:280:DC%2BD3c3hsVKntA%3D%3D Occurrence Handle10752972

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. National AIDS Research Institute, Indian Council of Medical Research, 73 G Block, MIDC Bhosari, Pune, 411026, Maharashtra, India

    Rewa M. Kohli, Suvarna Sane, Kishore Kumar, Ramesh S. Paranjape & Sanjay M. Mehendale

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  1. Rewa M. Kohli
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  2. Suvarna Sane
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  3. Kishore Kumar
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  4. Ramesh S. Paranjape
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  5. Sanjay M. Mehendale
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Correspondence to Rewa M. Kohli.

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Source of Funding: National AIDS Research Institute, Intra-mural funds Indian Council Of Medical Research, New Delhi, India.

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Kohli, R.M., Sane, S., Kumar, K. et al. Assessment of quality of life among HIV-infected persons in Pune, India. Qual Life Res 14, 1641–1647 (2005). https://doi.org/10.1007/s11136-004-7082-8

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