References
Freedman BI (2003) Susceptibility genes for hypertension and renal failure. J Am Soc Nephrol 14:S192
Kao WH, Klag MJ, Meoni LA et al (2008) MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 40:1185
Freedman BI, Edberg JC, Comeau ME et al (2010) The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. Am J Nephrol 32:66
Freedman BI, Kopp JB, Langefeld CD et al (2010) The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol 21:1422
Genovese G, Friedman DJ, Ross MD et al (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329:841
Genovese G, Tonna SJ, Knob AU et al (2010) A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. Kidney Int 78:698
Freedman BI, Parekh RS, Kao WH (2010) Genetic basis of nondiabetic end-stage renal disease. Semin Nephrol 30:101
Zenker M, Machuca E, Antignac C (2009) Genetics of nephrotic syndrome: new insights into molecules acting at the glomerular filtration barrier. J Mol Med 87:849
Brown EJ, Schlondorff JS, Becker DJ et al (2010) Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nat Genet 42:72
Kaplan JM, Kim SH, North KN et al (2000) Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 24:251
Reiser J, Polu KR, Moller CC et al (2005) TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 37:739
Freedman BI, Hicks PJ, Bostrom MA et al (2009) Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int 75:736
Kopp JB, Smith MW, Nelson GW et al (2008) MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet 40:1175
Oleksyk TK, Nelson GW, An P et al (2010) Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa. PLoS One 5:e11474
Kopp JB (2010) Glomerular pathology in autosomal dominant MYH9 spectrum disorders: what are the clues telling us about disease mechanism? Kidney Int 78:130
Nelson GW, Freedman BI, Bowden DW et al (2010) Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. Hum Mol Genet 19:1805
Vanhollebeke B, Pays E (2006) The function of apolipoproteins L. Cell Mol Life Sci 63:1937
Pays E, Vanhollebeke B, Vanhamme L et al (2006) The trypanolytic factor of human serum. Nat Rev Microbiol 4:477
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Zenker, M., Mertens, P.R. Arrest of the true culprit and acquittal of the innocent? Genetic revelations charge APOL1 variants with kidney disease susceptibility. Int Urol Nephrol 42, 1131–1134 (2010). https://doi.org/10.1007/s11255-010-9863-z
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DOI: https://doi.org/10.1007/s11255-010-9863-z