Abstract
Murine noroviruses (MNV) comprise a group of newly recognized pathogens infecting laboratory mice. The first reported murine norovirus, murine norovirus 1 (MNV-1), produces a transient infection with a short duration of fecal shedding after infection of immunocompetent laboratory mice. Our laboratory subsequently isolated three novel murine noroviruses, murine norovirus 2 (MNV-2), murine norovirus 3 (MNV-3), and murine norovirus 4 (MNV-4), that have markedly different pathogenicity from MNV-1 by producing persistent infections and prolonged fecal shedding in infected immunocompetent mice. In this study, the nucleotide sequences and the predicted amino acid sequences of the three novel murine noroviruses were determined and compared to each other, MNV-1, and other previously described human and animal noroviruses. The three novel murine norovirus strains were shown to be related to each other and MNV-1 by sequence and phylogenetic analysis even though MNV-2, MNV-3 and MNV-4 all display markedly different biologic behavior from that of MNV-1.
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Acknowledgements
The project described was supported by Grant Number T32-RR07004 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), the Mutant Mouse Resource and Research Center grant 2 U42 RR014821, and the National Institute of Allergy and Infectious Diseases Midwest Regional Center for Excellence grant U54 AI057160. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.
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The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession numbers DQ223041, DQ223042, and DQ223043.
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Hsu, C.C., Riley, L.K. & Livingston, R.S. Molecular characterization of three novel murine noroviruses. Virus Genes 34, 147–155 (2007). https://doi.org/10.1007/s11262-006-0060-1
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DOI: https://doi.org/10.1007/s11262-006-0060-1