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Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?

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An Erratum to this article was published on 09 February 2010

Abstract

Background

The purpose of this retrospective analysis was to determine if a short course of prophylactic proton pump inhibitor (PPI) therapy can prevent stomal ulceration after laparoscopic Roux-en-Y gastric bypass (LRYGBP).

Methods

Four hundred forty-nine consecutive patients who underwent LRYGBP and had a minimum of 6 months follow-up were included. Patients were categorized in two groups: patients with Helicobacter pylori at preoperative endoscopy (HP group) and patients without H. pylori (non-HP group). All patients in the HP group were medically treated prior to surgery. In both groups, almost half of the patients received low-dose proton pump inhibitors (omeprazole 20 mg daily) for 1 month following LRYGBP.

Results

The incidence of stomal ulceration in the HP group was not statistically different from the incidence in the non-HP group (7/86, 8.14% vs. 41/363, 11.29%; p = 0.559). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the non-HP group, there was no significant reduction in development of stomal ulceration (18/169, 10.65% vs. 23/194, 11.86%; p = 0.743). When comparing the patients who did receive PPI therapy with the patients who did not receive PPI therapy within the HP group, there is a significant reduction in development of stomal ulceration (0/41, 0% vs. 7/45, 15.56%; p = 0.0123).

Conclusion

Development of stomal ulceration in patients tested positive for H. pylori prior to LRYGBP can be prevented by prophylactic low-dose PPI therapy following surgery.

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Acknowledgements

The authors thank Mrs. K. Vanopdenbosch and Mrs. G. Vandendriessche for their administrative assistance and A. D’Hoore MD Phd and L. Lemmens MD for their critical review.

Nothing to disclose

None of the contents of our manuscript has previously been published in other journals. We have no financial or other relationships that might lead to a conflict of interest.

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Authors and Affiliations

  1. Groeninge Hospital, Houtmarkt 33, 8500, Kortrijk, Belgium

    Mathieu André D’Hondt, Dirk Devriendt, Frank Van Rooy & Franky Vansteenkiste

  2. Interdisciplinary Research Center, Katholieke Universiteit Leuven, Kortrijk, Belgium

    Hans Pottel

Authors
  1. Mathieu André D’Hondt
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  2. Hans Pottel
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  3. Dirk Devriendt
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  4. Frank Van Rooy
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  5. Franky Vansteenkiste
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Corresponding author

Correspondence to Mathieu André D’Hondt.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s11695-010-0084-4

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André D’Hondt, M., Pottel, H., Devriendt, D. et al. Can a Short Course of Prophylactic Low-dose Proton Pump Inhibitor Therapy Prevent Stomal Ulceration After Laparoscopic Roux-en-Y Gastric Bypass?. OBES SURG 20, 595–599 (2010). https://doi.org/10.1007/s11695-009-0062-x

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