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ESR1, FTO, and UCP2 Genes Interact with Bariatric Surgery Affecting Weight Loss and Glycemic Control in Severely Obese Patients

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An Erratum to this article was published on 07 December 2011

Abstract

Background

Significant variability in weight loss and glycemic control has been observed in obese patients receiving bariatric surgery. Genetic factors may play a role in the different outcomes.

Methods

Five hundred and twenty severely obese patients with body mass index (BMI) ≥35 were recruited. Among them, 149 and 371 subjects received laparoscopic adjustable gastric banding (LAGB) and laparoscopic mini-gastric bypass (LMGB), respectively. All individuals were genotyped for five obesity-related single nucleotide polymorphisms on ESR1, FTO, PPARγ, and UCP2 genes to explore how these genes affect weight loss and glycemic control after bariatric surgery at the 6th month.

Results

Obese patients with risk genotypes on rs660339-UCP2 had greater decrease in BMI after LAGB compared to patients with non-risk genotypes (−7.5 vs. −6 U, p = 0.02). In contrast, after LMGB, obese patients with risk genotypes on either rs712221-ESR1 or rs9939609-FTO had significant decreases in BMI (risk vs. non-risk genotype, −12.5 vs. −10.0 U on rs712221, p = 0.02 and −12.1 vs. −10.6 U on rs9939609, p = 0.04) and a significant amelioration in HbA1c levels (p = 0.038 for rs712221 and p < 0.0001 for rs9939609). The synergic effect of ESR1 and FTO genes on HbA1c amelioration was greater (−1.54%, p for trend <0.001) than any of these genes alone in obese patients receiving LMGB.

Conclusions

The genetic variants in the ESR, FTO, and UCP2 genes may be considered as a screening tool prior to bariatric surgery to help clinicians predict weight loss or glycemic control outcomes for severely obese patients.

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Acknowledgments

We gratefully acknowledge that this study is partially based on the results derived from Dr. Wen-Hern Pan of Academia Sinica and LM Chuang of National Taiwan University Hospital. We also thank the researchers and subjects for their participation. The authors also have a great appreciation for Taipei Medical University Hospital, Min-Sheng General Hospital, and Chang Jung University. This project supported by the National Science Council, NSC 100-2320-B-309-001.

Conflict of Interest

This paper is not currently being considered by other journals. All authors declare that they have no competing financial interests, agree to submit the paper to this journal, and transfer copyright to the publisher.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

    Tsan-Hon Liou

  2. Graduate Institute of Injury Prevention, Taipei Medical University, Taipei, Taiwan

    Tsan-Hon Liou

  3. Division of Epidemiology and Genetics, Chang Jung University, Tainan, Taiwan

    Hsin-Hung Chen

  4. Department of Medical Nutrition Therapies, Pan-Chiao Cathay Hospital, Taipei, Taiwan

    Hsin-Hung Chen

  5. Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan

    Weu Wang

  6. Department of Medical Administration, Pan-Chiao Cathay Hospital, Taipei, Taiwan

    Shu-Fen Wu

  7. Department of International Business, Ching Yun University, Jhongli, Taiwan

    Yi-Chih Lee

  8. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

    Wei-Shiung Yang

  9. Division of Surgery and Medical Therapy, Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan

    Wei-Jei Lee

  10. Department of Nutrition and Health Sciences, Chang Jung University, No. 396, Sec. 1, Changrong Rd., Gueiren Dist, Tainan, 71101, Taiwan

    Hsin-Hung Chen

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Correspondence to Hsin-Hung Chen.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s11695-011-0564-1

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Liou, TH., Chen, HH., Wang, W. et al. ESR1, FTO, and UCP2 Genes Interact with Bariatric Surgery Affecting Weight Loss and Glycemic Control in Severely Obese Patients. OBES SURG 21, 1758–1765 (2011). https://doi.org/10.1007/s11695-011-0457-3

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