Abstract
Objective
Traumatic neuromas are rare benign lesions occurring post-mastectomy, which are usually suspected as tumour recurrences before excision biopsy. We report six cases presenting with palpable nodules postmastectomy, to emphasize the differential diagnosis of traumatic neuroma from recurrent cancer.
Methods
Six cases were reviewed. The age of patients ranged from 33 to 61 years. Nodular masses were found close to the mastectomy scar during follow-up over a period of 2.8 to 8 years.
Results
In one patient three nodular masses were detected. Five patients had received chemotherapy, three of which had also received radiotherapy. Ultrasound examinations showed a well-circumscribed, homogeneous, hypo-echoic subcutaneous nodular lesion in four cases, and a poorly defined hypo-echoic nodule with good conduction in two cases. No obvious distant metastases had been identified. Each patient underwent surgical excisional biopsy. All of nodules had a diameter less than 1 cm. Histopathological examination showed proliferation of nerve fibre bundles, which were disordered, oriented and well circumscribed in fibro-adipose tissue.
Conclusion
It was concluded that all of the lesions were traumatic neuromas, independent from the initial tumor. Traumatic neuromas occurring in mastectomy scars are difficult to distinguish from a tumor recurrence. Although radiological evaluation of the mass with ultrasound is of value, the diagnosis can only be confirmed following a histopathological evaluation.
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References
Lee EJ, Calcaterra TC, Zuckerbraun L. Traumatic neuromas of the head and neck. Ear Nose Throat J. 1998; 77:670–674.
Nagata Y, Tomioka T, Chiba K, et al. Traumatic neuroma of the common hepatic duct after laparoscopic cholecystectomy. Am J Gastroenterol. 1995; 90:1887–1888.
Turani H, Chaimoff C, Lurie B. Amputation neuroma after cholecystectomy. A cause of intermittent obstructive jaundice. J Clin Gastroenterol. 1988; 10:101–103.
Iida S, Shirasuna K, Kogo M, et al. Amputation neuroma following radical neck dissection-report of 3 cases. J Osaka Univ Dent Sch. 1995; 35:1–4.
Batsakis JG. Tumors of the peripheral nervous system. In: Batsakis JF, editor. Tumors of the Head and Neck. Baltimore: Williams & Wilkins. 1974; 231–249.
Das Gupta TK, Brasfield RD. Amputation neuromas in cancer patients. N Y State J Med. 1969; 69:2129–2132.
Rosso R, Scelsi M, Carnevali L. Granular cell traumatic neuroma: a lesion occurring in mastectomy scars. Arch Pathol Lab Med. 2000; 124:709–711.
Baltalarli B, Demirkan N, Yagci B. Traumatic neuroma: unusual benign lesion occurring in the mastectomy scar. Clin Oncol (R Coll Radiol). 2004;16:503–504.
Beggs I. Sonographic appearances of nerve tumors. J Clin Ultrasound. 1999; 27:363–368.
Huang LF, Weissman JL, Fan C. Traumatic neuroma after neck dissection: CT characteristics in four cases. AJNR Am J Neuroradiol. 2000; 21:1676–1680.
Yabuuchi H, Kuroiwa T, Fukuya T, et al. Traumatic neuroma and recurrent lymphadenopathy after neck dissection: comparison of radiologic features. Radiol. 2004; 233:523–529.
Serrano Falcon C, Serrano Falcon Mdel M, Ruiz Villaverde R, et al. Amputation neuromas after neck surgery. Dermatol Online J. 2005; 11:24.
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Wang, X., Cao, X. & Ning, L. Traumatic neuromas in breast cancer patients after mastectomy. Chin. J. Clin. Oncol. 4, 185–188 (2007). https://doi.org/10.1007/s11805-007-0185-6
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DOI: https://doi.org/10.1007/s11805-007-0185-6