Abstract
The recreational use of the so-called “legal-highs” has been in both the medical and political arena over the last year as a result of the appearance of “head shops” in many towns in Ireland. These shops specialized in selling new psychotropic compounds that circumvented established drug legislation. Little is known about the potentially harmful effects of these substances but case reports suggest a plethora of harmful psychological and physical effects. Our case describes for the first time acute liver failure associated with the ingestion of two of these amphetamine type compounds.
Notes
Interview with head of the Department of Forensic Medicine at the University of Helsinki Helsingin Sanomat, Finland 16 March 2010.
References
Westphal F, Junge T, Rösner P et al (2009) Mass and NMR spectroscopic characterization of 3,4-methylenedioxypyrovalerone: a designer drugwith alpha-pyrrolidinophenone structure. Forensic Sci Int 190(1-3):1–8
Uchiyama N, Kikura-Hanajiri R, Kawahara N et al (2008) Analysis of designer drugs detected in the products purchased in fiscal year 2006. Yakugaku Zasshi 128(10):1499–1505
Lange-Brock N, Berg T, Müller AR et al (2002) Acute liver failure following the use of ecstasy (MDMA). Z Gastroenterol 40(8):581–586
Carvalho M, Remião F, Milhazes N et al (2004) The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 200(2–3):193–203
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Fröhlich, S., Lambe, E. & O’Dea, J. Acute liver failure following recreational use of psychotropic “head shop” compounds. Ir J Med Sci 180, 263–264 (2011). https://doi.org/10.1007/s11845-010-0636-6
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DOI: https://doi.org/10.1007/s11845-010-0636-6