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Susceptibility genes in severe asthma

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Abstract

Asthma is a common complex disease with a very wide spectrum of severity. Although part of this may be due to differing environmental interactions and inadequate treatment, there is increasing evidence that in addition to susceptibility genes for asthma onset, there are also important genetic influences over the disease severity, response to treatment, and natural history. In this review, we bring together recent literature in the .eld of genetic influences over disease severity and discuss some of the clinical implications in terms of drug discovery and personalized medicine.

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  1. Infection, Inflammation and Repair Division, Southampton General Hospital, MP810, F Level, South Block, SO16 6YD, Southampton, UK

    Stephen T. Holgate MD, FRCP, F Med Sci

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  1. Stephen T. Holgate MD, FRCP, F Med Sci
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Holgate, S.T. Susceptibility genes in severe asthma. Curr Allergy Asthma Rep 6, 345–348 (2006). https://doi.org/10.1007/s11882-006-0071-y

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