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Gender differences in lipoprotein metabolism and dietary response: Basis in hormonal differences and implications for cardiovascular disease

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Abstract

The transport of fat in the blood stream is approximately twice as fast in women as men. Disease states such as obesity and diabetes are associated with greater lipoprotein abnormalities in women compared with men. A greater increment in cardiovascular disease risk in women is linked to these abnormalities. A greater change in triglyceride level and a lesser change in low-density lipoprotein are observed in women than men with high-carbohydrate or high-fat feeding. Most consistent are greater changes in high-density lipoprotein (HDL), HDL2, and apolipoprotein A-I levels in women compared with men with high-carbohydrate or high-fat feeding. Dietary fat restriction in women appears to have a less beneficial lipoprotein effect than in men. Dietary fat restriction for heart disease prevention may be less ideal in women than in men.

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Authors and Affiliations

  1. Northwest Lipid Research Clinic, University of Washington, 325 9th Avenue, Box 359720, 98104, Seattle, WA, USA

    Robert H. Knopp MD

Authors
  1. Robert H. Knopp MD
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  2. Pathmaja Paramsothy MD
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  3. Barbara M. Retzlaff MPH, RD
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  4. Brian Fish BS
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  5. Carolyn Walden MS
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  6. Alice Dowdy MS, RD
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  7. Christine Tsunehara MS, RD
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  8. Keiko Aikawa MD
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  9. Marian C. Cheung PhD
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Knopp, R.H., Paramsothy, P., Retzlaff, B.M. et al. Gender differences in lipoprotein metabolism and dietary response: Basis in hormonal differences and implications for cardiovascular disease. Curr Atheroscler Rep 7, 472–479 (2005). https://doi.org/10.1007/s11883-005-0065-6

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  • DOI: https://doi.org/10.1007/s11883-005-0065-6

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