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Tumor-Infiltrating Lymphocytes in Melanoma

  • Melanoma (K Margolin, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) is arguably the most effective treatment for patients with metastatic melanoma. With higher response rates than ipilimumab or IL-2, and longer durations of response than vemurafenib, TIL therapy carries the potential to transform current outcomes in melanoma, while also defining the way cell-based immunotherapy gets incorporated into mainstream cancer treatment. This paper will review the current state of TIL therapy in melanoma, the strategies to improve its efficacy, the current obstacles, and future directions to expand the availability of TIL to the general patient population.

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Acknowledgments

This work was supported by the NCI K12 Career Development in Pediatric and Medical Oncology Award (K12CA076930). The authors thank Mark Dudley for discussions about TIL generation.

Disclosure

No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, 98195, USA

    Sylvia Lee & Kim Margolin

  2. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA

    Sylvia Lee & Kim Margolin

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  1. Sylvia Lee
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  2. Kim Margolin
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Correspondence to Sylvia Lee.

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Lee, S., Margolin, K. Tumor-Infiltrating Lymphocytes in Melanoma. Curr Oncol Rep 14, 468–474 (2012). https://doi.org/10.1007/s11912-012-0257-5

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  • DOI: https://doi.org/10.1007/s11912-012-0257-5

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