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A Perspective: Engineering Periosteum for Structural Bone Graft Healing

  • Symposium: New Approaches to Allograft Transplantation
  • Published:
Clinical Orthopaedics and Related Research

Abstract

Autograft is superior to both allograft and synthetic bone graft in repair of large structural bone defect largely due to the presence of multipotent mesenchymal stem cells in periosteum. Recent studies have provided further evidence that activation, expansion and differentiation of the donor periosteal progenitor cells are essential for the initiation of osteogenesis and angiogenesis of donor bone graft healing. The formation of donor cell-derived periosteal callus enables efficient host-dependent graft repair and remodeling at the later stage of healing. Removal of periosteum from bone autograft markedly impairs healing whereas engraftment of multipotent mesenchymal stem cells on bone allograft improves healing and graft incorporation. These studies provide rationale for fabrication of a biomimetic periosteum substitute that could fit bone of any size and shape for enhanced allograft healing and repair. The success of such an approach will depend on further understanding of the molecular signals that control inflammation, cellular recruitment as well as mesenchymal stem cell differentiation and expansion during the early phase of the repair process. It will also depend on multidisciplinary collaborations between biologists, material scientists and bioengineers to address issues of material selection and modification, biological and biomechanical parameters for functional evaluation of bone allograft healing.

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Acknowledgments

We thank Kimberly Napoli for her help in editing the manuscript.

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  1. The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY, 14642, USA

    Xinping Zhang PhD, Hani A. Awad PhD, Regis J. O’Keefe MD, PhD & Edward M. Schwarz PhD

  2. George W. Woodruff School of Mechanical Engineering, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA

    Robert E. Guldberg PhD

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  1. Xinping Zhang PhD
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Correspondence to Xinping Zhang PhD.

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Zhang, X., Awad, H.A., O’Keefe, R.J. et al. A Perspective: Engineering Periosteum for Structural Bone Graft Healing. Clin Orthop Relat Res 466, 1777–1787 (2008). https://doi.org/10.1007/s11999-008-0312-6

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