Skip to main content

Advertisement

SpringerLink
Log in

Adiponectin action from head to toe

  • Invited Review
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its involvement in obesity-related disorders such as insulin resistance, type 2 diabetes mellitus and atherosclerosis. Moreover, modulation of the circulating adiponectin concentration is observed in pathologies that are more or less obesity-related, such as cancer and rheumatoid arthritis. The wide distribution of adiponectin receptors in various organs and tissues suggests that adiponectin has pleiotropic effects on numerous physiological processes. Besides its well-known insulin-sensitizing, anti-inflammatory and antiatherosclerotic properties, accumulating evidence suggests that adiponectin may also have anticancer properties and be cardioprotective. A beneficial effect of adiponectin on female reproductive function was also suggested. Since adiponectin has numerous beneficial biological functions, its use as a therapeutic agent has been suggested. However, the use of adiponectin or its receptors as therapeutic targets is complicated by the presence of different adiponectin oligomeric isoforms and production sites, by multiple receptors with differing affinities for adiponectin isoforms, and by cell-type-specific effects in different tissues. In this review, we discuss the known and potential roles of adiponectin in various tissues and pathologies. The therapeutic promise of administration of adiponectin and the use of its circulating levels as a diagnostic biomarker are further discussed based on the latest experimental studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. P. Trayhurn, I.S. Wood, Br. J. Nutr. 92, 347–355 (2004)

    Article  PubMed  CAS  Google Scholar 

  2. S.E. Wozniak, L.L. Gee, M.S. Wachtel, E.E. Frezza, Dig. Dis. Sci. 54, 1847–1856 (2009)

    Article  PubMed  Google Scholar 

  3. D. Barb, K. Pazaitou-Panayiotou, C.S. Mantzoros, Expert Opin. Investig. Drugs 15, 917–931 (2006)

    Article  PubMed  CAS  Google Scholar 

  4. M. Nishida, T. Funahashi, I. Shimomura, Med. Mol. Morphol. 40, 55–67 (2007)

    Article  PubMed  CAS  Google Scholar 

  5. C. Hug, J. Wang, N.S. Ahmad, J.S. Bogan, T.S. Tsao, H.F. Lodish, Proc. Natl. Acad. Sci. USA 101, 10308–10313 (2004)

    Article  PubMed  CAS  Google Scholar 

  6. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, H.F. Lodish, J. Biol. Chem. 270, 26746–26749 (1995)

    Article  PubMed  CAS  Google Scholar 

  7. E. Hu, P. Liang, B.M. Spiegelman, J. Biol. Chem. 271, 10697–10703 (1996)

    Article  PubMed  CAS  Google Scholar 

  8. K. Maeda, K. Okubo, I. Shimomura, T. Funahashi, Y. Matsuzawa, K. Matsubara, Biochem. Biophys. Res. Commun. 221, 286–289 (1996)

    Article  PubMed  CAS  Google Scholar 

  9. Y. Nakano, T. Tobe, N.H. Choi-Miura, T. Mazda, M. Tomita, J. Biochem. 120, 803–812 (1996)

    PubMed  CAS  Google Scholar 

  10. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, J. Miyagawa, K. Hotta, I. Shimomura, T. Nakamura, K. Miyaoka, H. Kuriyama, M. Nishida, S. Yamashita, K. Okubo, K. Matsubara, M. Muraguchi, Y. Ohmoto, T. Funahashi, Y. Matsuzawa, Biochem. Biophys. Res. Commun. 257, 79–83 (1999)

    Article  PubMed  CAS  Google Scholar 

  11. L. Shapiro, P.E. Scherer, Curr. Biol. 8, 335–338 (1998)

    Article  PubMed  CAS  Google Scholar 

  12. Y. Wang, A. Xu, C. Knight, L.Y. Xu, G.J. Cooper, J. Biol. Chem. 277, 19521–19529 (2002)

    Article  PubMed  CAS  Google Scholar 

  13. U.B. Pajvani, X. Du, T.P. Combs, A.H. Berg, M.W. Rajala, T. Schulthess, J. Engel, M. Brownlee, P.E. Scherer, J. Biol. Chem. 278, 9073–9085 (2003)

    Article  PubMed  CAS  Google Scholar 

  14. T.S. Tsao, E. Tomas, H.E. Murrey, C. Hug, D.H. Lee, N.B. Ruderman, J.E. Heuser, H.F. Lodish, J. Biol. Chem. 278, 50810–50817 (2003)

    Article  PubMed  CAS  Google Scholar 

  15. Y. Wang, K.S. Lam, L. Chan, K.W. Chan, J.B. Lam, M.C. Lam, R.C. Hoo, W.W. Mak, G.J. Cooper, A. Xu, J. Biol. Chem. 281, 16391–16400 (2006)

    Article  PubMed  CAS  Google Scholar 

  16. J. Fruebis, T.S. Tsao, S. Javorschi, D. Ebbets-Reed, M.R. Erickson, F.T. Yen, B.E. Bihain, H.F. Lodish, Proc. Natl. Acad. Sci. USA 98, 2005–2010 (2001)

    Article  PubMed  CAS  Google Scholar 

  17. M.E. Trujillo, P.E. Scherer, J. Intern. Med. 257, 167–175 (2005)

    Article  PubMed  CAS  Google Scholar 

  18. N. Ouchi, H. Kobayashi, S. Kihara, M. Kumada, K. Sato, T. Inoue, T. Funahashi, K. Walsh, J. Biol. Chem. 279, 1304–1309 (2004)

    Article  PubMed  CAS  Google Scholar 

  19. T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, K. Tobe, J. Clin. Invest. 116, 1784–1792 (2006)

    Article  PubMed  CAS  Google Scholar 

  20. S. Maddineni, S. Metzger, O. Ocon, G. Hendricks 3rd, R. Ramachandran, Endocrinology 146, 4250–4256 (2005)

    Article  PubMed  CAS  Google Scholar 

  21. G.W. Wong, J. Wang, C. Hug, T.S. Tsao, H.F. Lodish, Proc. Natl. Acad. Sci. USA 101, 10302–10307 (2004)

    Article  PubMed  CAS  Google Scholar 

  22. M. Matsubara, S. Maruoka, S. Katayose, Eur. J. Endocrinol. 147, 173–180 (2002)

    Article  PubMed  CAS  Google Scholar 

  23. M. Cnop, P.J. Havel, K.M. Utzschneider, D.B. Carr, M.K. Sinha, E.J. Boyko, B.M. Retzlaff, R.H. Knopp, J.D. Brunzell, S.E. Kahn, Diabetologia. 46, 459–469 (2003)

    PubMed  CAS  Google Scholar 

  24. C. Lara-Castro, N. Luo, P. Wallace, R.L. Klein, W.T. Garvey, Diabetes 55, 249–259 (2006)

    Article  PubMed  CAS  Google Scholar 

  25. C. Weyer, T. Funahashi, S. Tanaka, K. Hotta, Y. Matsuzawa, R.E. Pratley, P.A. Tataranni, J. Clin. Endocrinol. Metab. 86, 1930–1935 (2001)

    Article  PubMed  CAS  Google Scholar 

  26. N. Kubota, Y. Terauchi, T. Yamauchi, T. Kubota, M. Moroi, J. Matsui, K. Eto, T. Yamashita, J. Kamon, H. Satoh, W. Yano, P. Froguel, R. Nagai, S. Kimura, T. Kadowaki, T. Noda, J. Biol. Chem. 277, 25863–25866 (2002)

    Article  PubMed  CAS  Google Scholar 

  27. N. Maeda, I. Shimomura, K. Kishida, H. Nishizawa, M. Matsuda, H. Nagaretani, N. Furuyama, H. Kondo, M. Takahashi, Y. Arita, R. Komuro, N. Ouchi, S. Kihara, Y. Tochino, K. Okutomi, M. Horie, S. Takeda, T. Aoyama, T. Funahashi, Y. Matsuzawa, Nat. Med. 8, 731–737 (2002)

    Article  PubMed  CAS  Google Scholar 

  28. N. Ouchi, M. Ohishi, S. Kihara, T. Funahashi, T. Nakamura, H. Nagaretani, M. Kumada, K. Ohashi, Y. Okamoto, H. Nishizawa, K. Kishida, N. Maeda, A. Nagasawa, H. Kobayashi, H. Hiraoka, N. Komai, M. Kaibe, H. Rakugi, T. Ogihara, Y. Matsuzawa, Hypertension 42, 231–234 (2003)

    Article  PubMed  CAS  Google Scholar 

  29. K. Saito, T. Tobe, S. Minoshima, S. Asakawa, J. Sumiya, M. Yoda, Y. Nakano, N. Shimizu, M. Tomita, Gene 229, 67–73 (1999)

    Article  PubMed  CAS  Google Scholar 

  30. F. Picard, M. Kurtev, N. Chung, A. Topark-Ngarm, T. Senawong, R. Machado De Oliveira, M. Leid, M.W. McBurney, L. Guarente, Nature 429, 771–776 (2004)

    Article  PubMed  CAS  Google Scholar 

  31. L. Qiao, J. Shao, J. Biol. Chem. 281, 39915–39924 (2006)

    Article  PubMed  CAS  Google Scholar 

  32. M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, R. Paschke, Biochem. Biophys. Res. Commun. 290, 1084–1089 (2002)

    Article  PubMed  CAS  Google Scholar 

  33. M.M. Swarbrick, P.J. Havel, Metab. Syndr. Relat. Disord. 6, 87–102 (2008)

    Article  PubMed  CAS  Google Scholar 

  34. N. Maeda, M. Takahashi, T. Funahashi, S. Kihara, H. Nishizawa, K. Kishida, H. Nagaretani, M. Matsuda, R. Komuro, N. Ouchi, H. Kuriyama, K. Hotta, T. Nakamura, I. Shimomura, Y. Matsuzawa, Diabetes 50, 2094–2099 (2001)

    Article  PubMed  CAS  Google Scholar 

  35. I.B. Bauche, S. Ait El Mkadem, R. Rezsohazy, T. Funahashi, N. Maeda, L.M. Miranda, S.M. Brichard, Biochem. Biophys. Res. Commun. 345, 1414–1424 (2006)

    Article  PubMed  CAS  Google Scholar 

  36. T. Yamauchi, J. Kamon, Y. Ito, A. Tsuchida, T. Yokomizo, S. Kita, T. Sugiyama, M. Miyagishi, K. Hara, M. Tsunoda, K. Murakami, T. Ohteki, S. Uchida, S. Takekawa, H. Waki, N.H. Tsuno, Y. Shibata, Y. Terauchi, P. Froguel, K. Tobe, S. Koyasu, K. Taira, T. Kitamura, T. Shimizu, R. Nagai, T. Kadowaki, Nature 423, 762–769 (2003)

    Article  PubMed  CAS  Google Scholar 

  37. E. Lord, S. Ledoux, B.D. Murphy, D. Beaudry, M.F. Palin, J. Anim. Sci. 83, 565–578 (2005)

    PubMed  CAS  Google Scholar 

  38. R. Ramachandran, O.M. Ocon-Grove, S.L. Metzger, Domest. Anim. Endocrinol. 33, 19–31 (2007)

    Article  PubMed  CAS  Google Scholar 

  39. M. Fasshauer, J. Klein, S. Kralisch, M. Klier, U. Lossner, M. Bluher, R. Paschke, FEBS Lett. 558, 27–32 (2004)

    Article  PubMed  CAS  Google Scholar 

  40. M. Bluher, M. Fasshauer, S. Kralisch, M.R. Schon, K. Krohn, R. Paschke, Biochem. Biophys. Res. Commun. 329, 1127–1132 (2005)

    Article  PubMed  CAS  Google Scholar 

  41. S.T. Ding, B.H. Liu, Y.H. Ko, J. Anim. Sci. 82, 3162–3174 (2004)

    PubMed  CAS  Google Scholar 

  42. X. Sun, J. He, C. Mao, R. Han, Z. Wang, Y. Liu, Y. Chen, FEBS Lett. 582, 3401–3407 (2008)

    Article  PubMed  CAS  Google Scholar 

  43. K. Inukai, Y. Nakashima, M. Watanabe, N. Takata, T. Sawa, S. Kurihara, T. Awata, S. Katayama, Am. J. Physiol. Endocrinol. Metab. 288, E876–E882 (2005)

    Article  PubMed  CAS  Google Scholar 

  44. M. Bjursell, A. Ahnmark, Y.M. Bohlooly, L. William-Olsson, M. Rhedin, X.R. Peng, K. Ploj, A.K. Gerdin, G. Arnerup, A. Elmgren, A.L. Berg, J. Oscarsson, D. Linden, Diabetes 56, 583–593 (2007)

    Article  PubMed  CAS  Google Scholar 

  45. D.B. Ivanov, M.P. Philippova, V.A. Tkachuk, Biochemistry (Mosc) 66, 1174–1186 (2001)

    Article  CAS  Google Scholar 

  46. M.H. Lee, R.L. Klein, H.M. El-Shewy, D.K. Luttrell, L.M. Luttrell, Biochemistry 47, 11682–11692 (2008)

    Article  PubMed  CAS  Google Scholar 

  47. C. Bromhead, J.H. Miller, F.J. McDonald, Gene 374, 58–67 (2006)

    Article  PubMed  CAS  Google Scholar 

  48. M.B. Joshi, M. Philippova, D. Ivanov, R. Allenspach, P. Erne, T.J. Resink, FASEB J. 19, 1737–1739 (2005)

    PubMed  CAS  Google Scholar 

  49. E. Kudrjashova, P. Bashtrikov, V. Bochkov, Y. Parfyonova, V. Tkachuk, J. Antropova, O. Iljinskaya, E. Tararak, P. Erne, D. Ivanov, M. Philippova, T.J. Resink, Histochem. Cell Biol. 118, 281–290 (2002)

    PubMed  CAS  Google Scholar 

  50. B.H. Liu, P.H. Wang, Y.C. Wang, W.M. Cheng, H.J. Mersmann, S.T. Ding, J. Anim. Sci. 86, 3377–3384 (2008)

    Article  PubMed  CAS  Google Scholar 

  51. S.S. Deepa, L.Q. Dong, Am. J. Physiol. Endocrinol. Metab. 296, E22–E36 (2009)

    Article  PubMed  CAS  Google Scholar 

  52. D.G. Hardie, J.W. Scott, D.A. Pan, E.R. Hudson, FEBS Lett. 546, 113–120 (2003)

    Article  PubMed  CAS  Google Scholar 

  53. T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, S. Uchida, S. Yamashita, M. Noda, S. Kita, K. Ueki, K. Eto, Y. Akanuma, P. Froguel, F. Foufelle, P. Ferre, D. Carling, S. Kimura, R. Nagai, B.B. Kahn, T. Kadowaki, Nat. Med. 8, 1288–1295 (2002)

    Article  PubMed  CAS  Google Scholar 

  54. J. Liu, F. Yao, R. Wu, M. Morgan, A. Thorburn, R.L. Finley Jr, Y.Q. Chen, J. Biol. Chem. 277, 26281–26285 (2002)

    Article  PubMed  CAS  Google Scholar 

  55. M. Miaczynska, S. Christoforidis, A. Giner, A. Shevchenko, S. Uttenweiler-Joseph, B. Habermann, M. Wilm, R.G. Parton, M. Zerial, Cell 116, 445–456 (2004)

    Article  PubMed  CAS  Google Scholar 

  56. A. Schenck, L. Goto-Silva, C. Collinet, M. Rhinn, A. Giner, B. Habermann, M. Brand, M. Zerial, Cell 133, 486–497 (2008)

    Article  PubMed  CAS  Google Scholar 

  57. X. Mao, C.K. Kikani, R.A. Riojas, P. Langlais, L. Wang, F.J. Ramos, Q. Fang, C.Y. Christ-Roberts, J.Y. Hong, R.Y. Kim, F. Liu, L.Q. Dong, Nat. Cell Biol. 8, 516–523 (2006)

    Article  PubMed  CAS  Google Scholar 

  58. G. Pearson, F. Robinson, T. Beers Gibson, B.E. Xu, M. Karandikar, K. Berman, M.H. Cobb, Endocr. Rev. 22, 153–183 (2001)

    Article  PubMed  CAS  Google Scholar 

  59. B. Chandrasekar, W.H. Boylston, K. Venkatachalam, N.J. Webster, S.D. Prabhu, A.J. Valente, J. Biol. Chem. 283, 24889–24898 (2008)

    Article  PubMed  CAS  Google Scholar 

  60. E. Budak, M. Fernandez Sanchez, J. Bellver, A. Cervero, C. Simon, A. Pellicer, Fertil. Steril. 85, 1563–1581 (2006)

    Article  PubMed  CAS  Google Scholar 

  61. The ESHRE Capri Workshop Group, Hum. Reprod. Update 12, 193–207 (2006)

    Article  Google Scholar 

  62. M. Mitchell, D.T. Armstrong, R.L. Robker, R.J. Norman, Reproduction (Cambridge, England) 130, 583–597 (2005)

    CAS  Google Scholar 

  63. Y. Gui, J.V. Silha, L.J. Murphy, Obes. Res. 12, 1481–1491 (2004)

    Article  PubMed  CAS  Google Scholar 

  64. A. Bottner, J. Kratzsch, G. Muller, T.M. Kapellen, S. Bluher, E. Keller, M. Bluher, W. Kiess, J. Clin. Endocrinol. Metab. 89, 4053–4061 (2004)

    Article  PubMed  CAS  Google Scholar 

  65. T.P. Combs, A.H. Berg, M.W. Rajala, S. Klebanov, P. Iyengar, J.C. Jimenez-Chillaron, M.E. Patti, S.L. Klein, R.S. Weinstein, P.E. Scherer, Diabetes 52, 268–276 (2003)

    Article  PubMed  CAS  Google Scholar 

  66. P.W. Peake, A.D. Kriketos, L.V. Campbell, Y. Shen, J.A. Charlesworth, Eur. J. Endocrinol. 153, 409–417 (2005)

    Article  PubMed  CAS  Google Scholar 

  67. S.T. Page, K.L. Herbst, J.K. Amory, A.D. Coviello, B.D. Anawalt, A.M. Matsumoto, W.J. Bremner, J. Androl. 26, 85–92 (2005)

    PubMed  CAS  Google Scholar 

  68. N. Chalvatzas, K. Dafopoulos, G. Kosmas, A. Kallitsaris, S. Pournaras, I.E. Messinis, Fertil. Steril. 91, 1189–1194 (2009)

    Article  PubMed  CAS  Google Scholar 

  69. L. Sieminska, C. Wojciechowska, D. Niedziolka, B. Marek, B. Kos-Kudla, D. Kajdaniuk, M. Nowak, Metabolism 54, 1610–1614 (2005)

    Article  PubMed  CAS  Google Scholar 

  70. C. Chabrolle, L. Tosca, J. Dupont, Reproduction 133, 719–731 (2007)

    Article  PubMed  CAS  Google Scholar 

  71. C. Chabrolle, L. Tosca, S. Crochet, S. Tesseraud, J. Dupont, Domest. Anim. Endocrinol. 33, 480–487 (2007)

    Article  PubMed  CAS  Google Scholar 

  72. S. Ledoux, D.B. Campos, F.L. Lopes, M. Dobias-Goff, M.F. Palin, B.D. Murphy, Endocrinology 147, 5178–5186 (2006)

    Article  PubMed  CAS  Google Scholar 

  73. D.V. Lagaly, P.Y. Aad, J.A. Grado-Ahuir, L.B. Hulsey, L.J. Spicer, Mol. Cell. Endocrinol. 284, 38–45 (2008)

    Article  PubMed  CAS  Google Scholar 

  74. J. Dupont, C. Chabrolle, C. Rame, L. Tosca, S. Coyral-Castel, PPAR Res. 2008, 176275 (2008)

    PubMed  Google Scholar 

  75. T. Leff, Biochem. Soc. Trans. 31, 224–227 (2003)

    Article  PubMed  CAS  Google Scholar 

  76. T. Kadowaki, T. Yamauchi, Endocr. Rev. 26, 439–451 (2005)

    Article  PubMed  CAS  Google Scholar 

  77. E.Y. Adashi, J. Reprod. Immunol. 39, 13–19 (1998)

    Article  PubMed  CAS  Google Scholar 

  78. K. Czaja, Soc. Reprod. Fertil. Suppl. 62, 45–53 (2006)

    PubMed  CAS  Google Scholar 

  79. S. Caja, M. Torrente, I. Martinez, M. Abelenda, M. Puerta, J. Endocrinol. Invest. 28, 609–615 (2005)

    PubMed  CAS  Google Scholar 

  80. M. Archanco, J. Gomez-Ambrosi, M. Tena-Sempere, G. Fruhbeck, M.A. Burrell, J. Histochem. Cytochem. 55, 1027–1037 (2007)

    Article  PubMed  CAS  Google Scholar 

  81. Y. Takemura, Y. Osuga, T. Yamauchi, M. Kobayashi, M. Harada, T. Hirata, C. Morimoto, Y. Hirota, O. Yoshino, K. Koga, T. Yano, T. Kadowaki, Y. Taketani, Endocrinology 147, 3203–3210 (2006)

    Article  PubMed  CAS  Google Scholar 

  82. T. Schmidt, S. Fischer, N. Tsikolia, A. Navarrete Santos, S. Rohrbach, N. Ramin, R. Thieme, B. Fischer, Histochem. Cell Biol. 129, 817–825 (2008)

    Article  PubMed  CAS  Google Scholar 

  83. E. Chappaz, M.S. Albornoz, D. Campos, L. Che, M.F. Palin, B.D. Murphy, V. Bordignon, Domest. Anim. Endocrinol. 35, 198–207 (2008)

    Article  PubMed  CAS  Google Scholar 

  84. J. Chen, B. Tan, E. Karteris, S. Zervou, J. Digby, E.W. Hillhouse, M. Vatish, H.S. Randeva, Diabetologia 49, 1292–1302 (2006)

    Article  PubMed  CAS  Google Scholar 

  85. S. Corbetta, G. Bulfamante, D. Cortelazzi, V. Barresi, I. Cetin, G. Mantovani, S. Bondioni, P. Beck-Peccoz, A. Spada, J. Clin. Endocrinol. Metab. 90, 2397–2402 (2005)

    Article  PubMed  CAS  Google Scholar 

  86. E. Kajantie, T. Hytinantti, P. Hovi, S. Andersson, J. Clin. Endocrinol. Metab. 89, 4031–4036 (2004)

    Article  PubMed  CAS  Google Scholar 

  87. S. Mazaki-Tovi, H. Kanety, E. Sivan, Curr. Diab. Rep. 5, 278–281 (2005)

    Article  PubMed  CAS  Google Scholar 

  88. M. Weyermann, C. Beermann, H. Brenner, D. Rothenbacher, Clin. Chem. 52, 2095–2102 (2006)

    Article  PubMed  CAS  Google Scholar 

  89. H. Pinar, S. Basu, K. Hotmire, L. Laffineuse, L. Presley, M. Carpenter, P.M. Catalano, S. Hauguel-de Mouzon, J. Clin. Endocrinol. Metab. 93, 2885–2890 (2008)

    Article  PubMed  CAS  Google Scholar 

  90. S. Mazaki-Tovi, H. Kanety, C. Pariente, R. Hemi, Y. Efraty, E. Schiff, A. Shoham, E. Sivan, J. Reprod. Med. 52, 774–778 (2007)

    PubMed  CAS  Google Scholar 

  91. D. Cortelazzi, S. Corbetta, S. Ronzoni, F. Pelle, A. Marconi, V. Cozzi, I. Cetin, R. Cortelazzi, P. Beck-Peccoz, A. Spada, Clin. Endocrinol. (Oxf) 66, 447–453 (2007)

    Article  CAS  Google Scholar 

  92. G. Baviera, F. Corrado, C. Dugo, M.L. Cannata, S. Russo, D. Rosario, Clin. Chem. 53, 1723–1724 (2007)

    Article  PubMed  CAS  Google Scholar 

  93. J. Fuglsang, C. Skjaerbaek, J. Frystyk, A. Flyvbjerg, P. Ovesen, BJOG 113, 110–113 (2006)

    PubMed  CAS  Google Scholar 

  94. J.K. Nien, S. Mazaki-Tovi, R. Romero, O. Erez, J.P. Kusanovic, F. Gotsch, B.L. Pineles, R. Gomez, S. Edwin, M. Mazor, J. Espinoza, B.H. Yoon, S.S. Hassan, J. Perinat. Med. 35, 522–531 (2007)

    Article  PubMed  CAS  Google Scholar 

  95. K. Naruse, M. Yamasaki, H. Umekage, T. Sado, Y. Sakamoto, H. Morikawa, J. Reprod. Immunol. 65, 65–75 (2005)

    Article  PubMed  CAS  Google Scholar 

  96. P.M. Catalano, M. Hoegh, J. Minium, L. Huston-Presley, S. Bernard, S. Kalhan, S. Hauguel-De Mouzon, Diabetologia 49, 1677–1685 (2006)

    Article  PubMed  CAS  Google Scholar 

  97. A.A. Houde, B.D. Murphy, O. Mathieu, V. Bordignon, M.F. Palin, Anim. Genet. 39, 249–257 (2008)

    Article  PubMed  CAS  Google Scholar 

  98. N.W. Cheung, K. Byth, Diabetes Care 26, 2005–2009 (2003)

    Article  PubMed  Google Scholar 

  99. S. Mazaki-Tovi, R. Romero, E. Vaisbuch, O. Erez, P. Mittal, T. Chaiworapongsa, S.K. Kim, P. Pacora, L. Yeo, F. Gotsch, Z. Dong, B.H. Yoon, S.S. Hassan, J.P. Kusanovic, J. Perinat. Med. 37, 637–650 (2009)

    Article  PubMed  CAS  Google Scholar 

  100. K.Y. Lain, A.R. Daftary, R.B. Ness, J.M. Roberts, Clin. Endocrinol. (Oxf) 69, 407–411 (2008)

    Article  Google Scholar 

  101. J. Bienertova-Vasku, Z. Dostalova, K. Kankova, P. Bienert, A. Vasku, V. Unzeitig, J. Obstet. Gynaecol. Res. 34, 858–864 (2008)

    Article  PubMed  CAS  Google Scholar 

  102. R. D’Anna, G. Baviera, F. Corrado, D. Giordano, A. De Vivo, G. Nicocia, A. Di Benedetto, BJOG 113, 1264–1269 (2006)

    Article  PubMed  CAS  Google Scholar 

  103. A.J. O’Sullivan, A.D. Kriketos, A. Martin, M.A. Brown, Hypertens. Pregnancy 25, 193–203 (2006)

    Article  PubMed  CAS  Google Scholar 

  104. R. D’Anna, G. Baviera, F. Corrado, D. Giordano, A. Di Benedetto, V.M. Jasonni, Obstet. Gynecol. 106, 340–344 (2005)

    PubMed  Google Scholar 

  105. S. Franks, N. Engl. J. Med. 333, 853–861 (1995)

    Article  PubMed  CAS  Google Scholar 

  106. M. Brassard, Y. AinMelk, J.P. Baillargeon, Med. Clin. North Am. 92, 1163–1192, xi (2008)

    Google Scholar 

  107. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Hum. Reprod. 19, 41–47 (2004)

    Article  Google Scholar 

  108. L. Sieminska, B. Marek, B. Kos-Kudla, D. Niedziolka, D. Kajdaniuk, M. Nowak, J. Glogowska-Szelag, J. Endocrinol. Invest. 27, 528–534 (2004)

    PubMed  CAS  Google Scholar 

  109. T. Apridonidze, P.A. Essah, M.J. Iuorno, J.E. Nestler, J. Clin. Endocrinol. Metab. 90, 1929–1935 (2005)

    Article  PubMed  CAS  Google Scholar 

  110. B. Yildirim, N. Sabir, B. Kaleli, Fertil. Steril. 79, 1358–1364 (2003)

    Article  PubMed  Google Scholar 

  111. C.G. Solomon, Endocrinol. Metab. Clin. North Am. 28, 247–263 (1999)

    Article  PubMed  CAS  Google Scholar 

  112. M.S. Ardawi, A.A. Rouzi, Fertil. Steril. 83, 1708–1716 (2005)

    Article  PubMed  CAS  Google Scholar 

  113. H.F. Escobar-Morreale, G. Villuendas, J.I. Botella-Carretero, F. Alvarez-Blasco, R. Sanchon, M. Luque-Ramirez, J.L. San Millan, Hum. Reprod. 21, 2257–2265 (2006)

    Article  PubMed  CAS  Google Scholar 

  114. D. Glintborg, J. Frystyk, K. Hojlund, K.K. Andersen, J.E. Henriksen, A.P. Hermann, C. Hagen, A. Flyvbjerg, M. Andersen, Clin. Endocrinol. (Oxf) 68, 165–174 (2008)

    CAS  Google Scholar 

  115. V. Aroda, T.P. Ciaraldi, S.A. Chang, M.H. Dahan, R.J. Chang, R.R. Henry, Fertil. Steril. 89, 1200–1208 (2008)

    Article  PubMed  CAS  Google Scholar 

  116. E Carmina, M.C. Chu, C. Moran, D. Tortoriello, P. Vardhana, G. Tena, R. Preciado, R. Lobo, Fertil. Steril. 89, 642–648 (2008)

    Article  PubMed  CAS  Google Scholar 

  117. M. Jensterle, M. Weber, M. Pfeifer, J. Prezelj, A. Pfutzner, A. Janez, Int. J. Gynaecol. Obstet. 102, 137–140 (2008)

    Article  PubMed  CAS  Google Scholar 

  118. J. Jakubowska, A. Bohdanowicz-Pawlak, A. Milewicz, J. Szymczak, G. Bednarek-Tupikowska, M. Demissie, Gynecol. Endocrinol. 24, 378–384 (2008)

    Article  PubMed  CAS  Google Scholar 

  119. D. Panidis, A. Kourtis, D. Farmakiotis, T. Mouslech, D. Rousso, G. Koliakos, Hum. Reprod. 18, 1790–1796 (2003)

    Article  PubMed  CAS  Google Scholar 

  120. F. Orio Jr, S. Palomba, T. Cascella, G. Milan, R. Mioni, C. Pagano, F. Zullo, A. Colao, G. Lombardi, R. Vettor, J. Clin. Endocrinol. Metab. 88, 2619–2623 (2003)

    Article  PubMed  CAS  Google Scholar 

  121. J. Spranger, M. Mohlig, U. Wegewitz, M. Ristow, A.F. Pfeiffer, T. Schill, H.W. Schlosser, G. Brabant, C. Schofl, Clin. Endocrinol. (Oxf) 61, 738–746 (2004)

    Article  CAS  Google Scholar 

  122. M. Haap, F. Machicao, N. Stefan, C. Thamer, O. Tschritter, F. Schnuck, D. Wallwiener, M. Stumvoll, H.U. Haring, A. Fritsche, Exp. Clin. Endocrinol. Diabetes 113, 275–281 (2005)

    Article  PubMed  CAS  Google Scholar 

  123. K.C. Lewandowski, K. Szosland, C. O’Callaghan, B.K. Tan, H.S. Randeva, A. Lewinski, Mol. Genet. Metab. 85, 61–69 (2005)

    Article  PubMed  CAS  Google Scholar 

  124. N.E. Gulcelik, Y. Aral, R. Serter, G. Koc, J. Natl. Med. Assoc. 100, 64–68 (2008)

    PubMed  Google Scholar 

  125. S. Weerakiet, P. Bunnag, B. Phakdeekitcharoen, S. Wansumrith, S. Chanprasertyothin, R. Jultanmas, A. Thakkinstian, Gynecol. Endocrinol. 23, 153–160 (2007)

    Article  PubMed  Google Scholar 

  126. W. Bik, A. Baranowska-Bik, E. Wolinska-Witort, M. Chmielowska, L. Martynska, B. Baranowska, Gynecol. Endocrinol. 23, 325–331 (2007)

    Article  PubMed  CAS  Google Scholar 

  127. R. Shroff, A. Kerchner, M. Maifeld, E.J. Van Beek, D. Jagasia, A. Dokras, J. Clin. Endocrinol. Metab. 92, 4609–4614 (2007)

    Article  PubMed  CAS  Google Scholar 

  128. T.M. Barber, M. Hazell, C. Christodoulides, S.J. Golding, C. Alvey, K. Burling, A. Vidal-Puig, N.P. Groome, J.A. Wass, S. Franks, M.I. McCarthy, J. Clin. Endocrinol. Metab. 93, 2859–2865 (2008)

    Article  PubMed  CAS  Google Scholar 

  129. A. Xu, Y. Wang, H. Keshaw, L.Y. Xu, K.S. Lam, G.J. Cooper, J. Clin. Invest. 112, 91–100 (2003)

    PubMed  CAS  Google Scholar 

  130. V. Sepilian, M. Nagamani, J. Soc. Gynecol. Investig. 12, 129–134 (2005)

    Article  PubMed  CAS  Google Scholar 

  131. D. Panidis, A. Kourtis, A. Kukuvitis, D. Farmakiotis, N. Xita, I. Georgiou, A. Tsatsoulis, Hum. Reprod. 19, 1728–1733 (2004)

    Article  PubMed  CAS  Google Scholar 

  132. N. Zhang, Y.H. Shi, C.F. Hao, H.F. Gu, Y. Li, Y.R. Zhao, L.C. Wang, Z.J. Chen, Eur. J. Endocrinol. 158, 255–260 (2008)

    Article  PubMed  CAS  Google Scholar 

  133. N. Xita, I. Georgiou, A. Chatzikyriakidou, M. Vounatsou, G.P. Papassotiriou, I. Papassotiriou, A. Tsatsoulis, Clin. Chem. 51, 416–423 (2005)

    Article  PubMed  CAS  Google Scholar 

  134. T. Sir-Petermann, M. Maliqueo, E. Codner, B. Echiburu, N. Crisosto, V. Perez, F. Perez-Bravo, F. Cassorla, J. Clin. Endocrinol. Metab. 92, 4637–4642 (2007)

    Article  PubMed  CAS  Google Scholar 

  135. M. Yilmaz, N. Bukan, R. Ersoy, A. Karakoc, I. Yetkin, G. Ayvaz, N. Cakir, M. Arslan, Hum. Reprod. 20, 2414–2420 (2005)

    Article  PubMed  CAS  Google Scholar 

  136. S.E. Recabarren, R. Smith, R. Rios, M. Maliqueo, B. Echiburu, E. Codner, F. Cassorla, P. Rojas, T. Sir-Petermann, J. Clin. Endocrinol. Metab. 93, 1820–1826 (2008)

    Article  PubMed  CAS  Google Scholar 

  137. A.M. Wolf, D. Wolf, M.A. Avila, A.R. Moschen, C. Berasain, B. Enrich, H. Rumpold, H. Tilg, J. Hepatol. 44, 537–543 (2006)

    Article  PubMed  CAS  Google Scholar 

  138. M. Yoda-Murakami, M. Taniguchi, K. Takahashi, S. Kawamata, K. Saito, N.H. Choi-Miura, M. Tomita, Biochem. Biophys. Res. Commun. 285, 372–377 (2001)

    Article  PubMed  CAS  Google Scholar 

  139. F. Oana, H. Takeda, A. Matsuzawa, S. Akahane, M. Isaji, M. Akahane, Eur. J. Pharmacol. 518, 71–76 (2005)

    Article  PubMed  CAS  Google Scholar 

  140. R. Vuppalanchi, S. Marri, D. Kolwankar, R.V. Considine, N. Chalasani, J. Clin. Gastroenterol. 39, 237–242 (2005)

    Article  PubMed  Google Scholar 

  141. A. Tsuchida, T. Yamauchi, Y. Ito, Y. Hada, T. Maki, S. Takekawa, J. Kamon, M. Kobayashi, R. Suzuki, K. Hara, N. Kubota, Y. Terauchi, P. Froguel, J. Nakae, M. Kasuga, D. Accili, K. Tobe, K. Ueki, R. Nagai, T. Kadowaki, J. Biol. Chem. 279, 30817–30822 (2004)

    Article  PubMed  CAS  Google Scholar 

  142. T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, T. Kadowaki, Nat. Med. 7, 941–946 (2001)

    Article  PubMed  CAS  Google Scholar 

  143. M. Awazawa, K. Ueki, K. Inabe, T. Yamauchi, K. Kaneko, Y. Okazaki, N. Bardeesy, S. Ohnishi, R. Nagai, T. Kadowaki, Biochem. Biophys. Res. Commun. 382, 51–56 (2009)

    Article  PubMed  CAS  Google Scholar 

  144. A.H. Berg, T.P. Combs, X. Du, M. Brownlee, P.E. Scherer, Nat. Med. 7, 947–953 (2001)

    Article  PubMed  CAS  Google Scholar 

  145. M. Neumeier, C. Hellerbrand, E. Gabele, R. Buettner, C. Bollheimer, J. Weigert, A. Schaffler, T.S. Weiss, M. Lichtenauer, J. Scholmerich, C. Buechler, World J. Gastroenterol. 12, 5490–5494 (2006)

    PubMed  CAS  Google Scholar 

  146. E. Durante-Mangoni, R. Zampino, A. Marrone, M.F. Tripodi, L. Rinaldi, L. Restivo, M. Cioffi, G. Ruggiero, L.E. Adinolfi, Aliment. Pharmacol. Ther. 24, 1349–1357 (2006)

    Article  PubMed  CAS  Google Scholar 

  147. K. Tokushige, E. Hashimoto, H. Noto, S. Yatsuji, M. Taniai, N. Torii, K. Shiratori, J. Gastroenterol. 44, 976–982 (2009)

    Article  PubMed  CAS  Google Scholar 

  148. A. Kotronen, H. Yki-Jarvinen, A. Aminoff, R. Bergholm, K.H. Pietilainen, J. Westerbacka, P.J. Talmud, S.E. Humphries, A. Hamsten, B. Isomaa, L. Groop, M. Orho-Melander, E. Ehrenborg, R.M. Fisher, Eur. J. Endocrinol. 160, 593–602 (2009)

    Article  PubMed  CAS  Google Scholar 

  149. E. Tsochatzis, G.V. Papatheodoridis, A.J. Archimandritis, Am. J. Gastroenterol. 101, 2629–2640 (2006)

    PubMed  CAS  Google Scholar 

  150. H. Staiger, C. Kausch, A. Guirguis, M. Weisser, E. Maerker, M. Stumvoll, R. Lammers, F. Machicao, H.U. Haring, Diabetologia 46, 956–960 (2003)

    Article  PubMed  CAS  Google Scholar 

  151. A.M. Delaigle, J.C. Jonas, I.B. Bauche, O. Cornu, S.M. Brichard, Endocrinology 145, 5589–5597 (2004)

    Article  PubMed  CAS  Google Scholar 

  152. C. Punyadeera, A.H. Zorenc, R. Koopman, A.J. McAinch, E. Smit, R. Manders, H.A. Keizer, D. Cameron-Smith, L.J. van Loon, Eur. J. Endocrinol. 152, 427–436 (2005)

    Article  PubMed  CAS  Google Scholar 

  153. M.P. Krause, Y. Liu, V. Vu, L. Chan, A. Xu, M.C. Riddell, G. Sweeney, T.J. Hawke, Am J. Physiol. Cell. Physiol. 295, C203–C212 (2008)

    Article  PubMed  CAS  Google Scholar 

  154. T. Fiaschi, D. Cirelli, G. Comito, S. Gelmini, G. Ramponi, M. Serio, P. Chiarugi, Cell Res. 19, 584–597 (2009)

    Article  PubMed  CAS  Google Scholar 

  155. M.J. Yoon, G.Y. Lee, J.J. Chung, Y.H. Ahn, S.H. Hong, J.B. Kim, Diabetes 55, 2562–2570 (2006)

    Article  PubMed  CAS  Google Scholar 

  156. E. Tomas, T.S. Tsao, A.K. Saha, H.E. Murrey, C.C. Zhang, S.I. Itani, H.F. Lodish, N.B. Ruderman, Proc. Natl. Acad. Sci. USA 99, 16309–16313 (2002)

    Article  PubMed  CAS  Google Scholar 

  157. R.B. Ceddia, R. Somwar, A. Maida, X. Fang, G. Bikopoulos, G. Sweeney, Diabetologia 48, 132–139 (2005)

    Article  PubMed  CAS  Google Scholar 

  158. X. Fang, R. Palanivel, X. Zhou, Y. Liu, A. Xu, Y. Wang, G. Sweeney, J. Mol. Endocrinol. 35, 465–476 (2005)

    Article  PubMed  CAS  Google Scholar 

  159. T. Yamauchi, Y. Nio, T. Maki, M. Kobayashi, T. Takazawa, M. Iwabu, M. Okada-Iwabu, S. Kawamoto, N. Kubota, T. Kubota, Y. Ito, J. Kamon, A. Tsuchida, K. Kumagai, H. Kozono, Y. Hada, H. Ogata, K. Tokuyama, M. Tsunoda, T. Ide, K. Murakami, M. Awazawa, I. Takamoto, P. Froguel, K. Hara, K. Tobe, R. Nagai, K. Ueki, T. Kadowaki, Nat. Med. 13, 332–339 (2007)

    Article  PubMed  CAS  Google Scholar 

  160. Y. Liu, S. Chewchuk, C. Lavigne, S. Brule, G. Pilon, V. Houde, A. Xu, A. Marette, G. Sweeney, Am. J. Physiol. Endocrinol. Metab. 297, E657–E664 (2009)

    Article  PubMed  CAS  Google Scholar 

  161. C. Bonnard, A. Durand, H. Vidal, J. Rieusset, Diabetes Metab. 34, 52–61 (2008)

    Article  PubMed  CAS  Google Scholar 

  162. L.J. Prior, E. Velkoska, R. Watts, D. Cameron-Smith, M.J. Morris, Int. J. Obes. (Lond). 32, 1585–1594 (2008)

    Article  CAS  Google Scholar 

  163. K.L. Mullen, J. Pritchard, I. Ritchie, L.A. Snook, A. Chabowski, A. Bonen, D. Wright, D.J. Dyck, Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R243–R251 (2009)

    PubMed  CAS  Google Scholar 

  164. K.L. Mullen, A.C. Smith, K.A. Junkin, D.J. Dyck, Am. J. Physiol. Endocrinol. Metab. 293, E83–E90 (2007)

    Article  PubMed  CAS  Google Scholar 

  165. H. Kuoppamaa, P. Skrobuk, M. Sihvo, A. Hiukka, A.V. Chibalin, J.R. Zierath, H.A. Koistinen, Diabetes Metab. Res. Rev. 24, 554–562 (2008)

    Article  PubMed  CAS  Google Scholar 

  166. E. Ingelsson, J. Arnlov, B. Zethelius, R.S. Vasan, A. Flyvbjerg, J. Frystyk, C. Berne, A. Hanni, L. Lind, J. Sundstrom, J. Clin. Endocrinol. Metab. 94, 953–957 (2009)

    Article  PubMed  CAS  Google Scholar 

  167. M. Du, Q.W. Shen, M.J. Zhu, S.P. Ford, J. Anim. Sci. 85, 919–927 (2007)

    Article  PubMed  CAS  Google Scholar 

  168. K. Nakashima, Y. Yakabe, Biosci. Biotechnol. Biochem. 71, 1650–1656 (2007)

    Article  PubMed  CAS  Google Scholar 

  169. Q. Zhou, J. Du, Z. Hu, K. Walsh, X.H. Wang, Endocrinology 148, 5696–5705 (2007)

    Article  PubMed  CAS  Google Scholar 

  170. X. Wang, Z. Hu, J. Hu, J. Du, W.E. Mitch, Endocrinology 147, 4160–4168 (2006)

    Article  PubMed  CAS  Google Scholar 

  171. Y. Ikegami, K. Inukai, K. Imai, Y. Sakamoto, H. Katagiri, S. Kurihara, T. Awata, S. Katayama, Diabetes 58, 61–70 (2009)

    Article  PubMed  CAS  Google Scholar 

  172. I. Kharroubi, J. Rasschaert, D.L. Eizirik, M. Cnop, Biochem. Biophys. Res. Commun. 312, 1118–1122 (2003)

    Article  PubMed  CAS  Google Scholar 

  173. T.E. Wade, A. Mathur, D. Lu, D.A. Swartz-Basile, H.A. Pitt, N.J. Zyromski, J. Surg. Res. 154, 78–84 (2009)

    Article  PubMed  CAS  Google Scholar 

  174. M. Okamoto, M. Ohara-Imaizumi, N. Kubota, S. Hashimoto, K. Eto, T. Kanno, T. Kubota, M. Wakui, R. Nagai, M. Noda, S. Nagamatsu, T. Kadowaki, Diabetologia 51, 827–835 (2008)

    Article  PubMed  CAS  Google Scholar 

  175. W. Gu, X. Li, C. Liu, J. Yang, L. Ye, J. Tang, Y. Gu, Y. Yang, J. Hong, Y. Zhang, M. Chen, G. Ning, Endocrine 30, 217–221 (2006)

    Article  PubMed  CAS  Google Scholar 

  176. I. Rakatzi, H. Mueller, O. Ritzeler, N. Tennagels, J. Eckel, Diabetologia 47, 249–258 (2004)

    Article  PubMed  CAS  Google Scholar 

  177. N.J. Zyromski, A. Mathur, H.A. Pitt, T.E. Wade, S. Wang, D.A. Swartz-Basile, A.D. Prather, K.D. Lillemoe, J. Gastrointest. Surg. 13, 831–838 (2009)

    Article  PubMed  Google Scholar 

  178. N.J. Zyromski, A. Mathur, H.A. Pitt, D. Lu, J.T. Gripe, J.J. Walker, K. Yancey, T.E. Wade, D.A. Swartz-Basile, Am. J. Physiol. Gastrointest. Liver Physiol. 295, G552–G558 (2008)

    Article  PubMed  CAS  Google Scholar 

  179. E. Tukiainen, M.L. Kylanpaa, P. Ebeling, E. Kemppainen, P. Puolakkainen, H. Repo, Pancreas 32, 211–214 (2006)

    Article  PubMed  CAS  Google Scholar 

  180. K. Adrych, M. Smoczynski, E. Stelmanska, J. Korczynska, E. Goyke, J. Swierczynski, Pancreas 36, 120–124 (2008)

    Article  PubMed  CAS  Google Scholar 

  181. Y. Qi, N. Takahashi, S.M. Hileman, H.R. Patel, A.H. Berg, U.B. Pajvani, P.E. Scherer, R.S. Ahima, Nat. Med. 10, 524–529 (2004)

    Article  PubMed  CAS  Google Scholar 

  182. N. Kubota, W. Yano, T. Kubota, T. Yamauchi, S. Itoh, H. Kumagai, H. Kozono, I. Takamoto, S. Okamoto, T. Shiuchi, R. Suzuki, H. Satoh, A. Tsuchida, M. Moroi, K. Sugi, T. Noda, H. Ebinuma, Y. Ueta, T. Kondo, E. Araki, O. Ezaki, R. Nagai, K. Tobe, Y. Terauchi, K. Ueki, Y. Minokoshi, T. Kadowaki, Cell Metab. 6, 55–68 (2007)

    Article  PubMed  CAS  Google Scholar 

  183. J. Spranger, S. Verma, I. Gohring, T. Bobbert, J. Seifert, A.L. Sindler, A. Pfeiffer, S.M. Hileman, M. Tschop, W.A. Banks, Diabetes 55, 141–147 (2006)

    Article  PubMed  CAS  Google Scholar 

  184. M. Neumeier, J. Weigert, R. Buettner, J. Wanninger, A. Schaffler, A.M. Muller, S. Killian, S. Sauerbruch, F. Schlachetzki, A. Steinbrecher, C. Aslanidis, J. Scholmerich, C. Buechler, Am. J. Physiol. Endocrinol. Metab. 293, E965–E969 (2007)

    Article  PubMed  CAS  Google Scholar 

  185. F. Rodriguez-Pacheco, A.J. Martinez-Fuentes, S. Tovar, L. Pinilla, M. Tena-Sempere, C. Dieguez, J.P. Castano, M.M. Malagon, Endocrinology 148, 401–410 (2007)

    Article  PubMed  CAS  Google Scholar 

  186. A. Psilopanagioti, H. Papadaki, E.F. Kranioti, T.K. Alexandrides, J.N. Varakis, Neuroendocrinology 89, 38–47 (2009)

    Article  PubMed  CAS  Google Scholar 

  187. T.D. Hoyda, M. Fry, R.S. Ahima, A.V. Ferguson, J. Physiol. 585, 805–816 (2007)

    Article  PubMed  CAS  Google Scholar 

  188. T.D. Hoyda, W.K. Samson, A.V. Ferguson, Endocrinology 150, 832–840 (2009)

    Article  PubMed  CAS  Google Scholar 

  189. M.P. Chen, J.C. Tsai, F.M. Chung, S.S. Yang, L.L. Hsing, S.J. Shin, Y.J. Lee, Arterioscler. Thromb. Vasc. Biol. 25, 821–826 (2005)

    Article  PubMed  CAS  Google Scholar 

  190. S. Soderberg, B. Stegmayr, H. Stenlund, L.G. Sjostrom, A. Agren, L. Johansson, L. Weinehall, T. Olsson, J. Intern. Med. 256, 128–136 (2004)

    Article  PubMed  CAS  Google Scholar 

  191. M. Matsumoto, S. Ishikawa, E. Kajii, Stroke 39, 323–328 (2008)

    Article  PubMed  CAS  Google Scholar 

  192. M. Nishimura, Y. Izumiya, A. Higuchi, R. Shibata, J. Qiu, C. Kudo, H.K. Shin, M.A. Moskowitz, N. Ouchi, Circulation 117, 216–223 (2008)

    Article  PubMed  CAS  Google Scholar 

  193. B.L. Peterlin, M.E. Bigal, S.J. Tepper, M. Urakaze, F.D. Sheftell, A.M. Rapoport, Cephalalgia 27, 435–446 (2007)

    Article  PubMed  CAS  Google Scholar 

  194. T. Yokota, C.S. Meka, T. Kouro, K.L. Medina, H. Igarashi, M. Takahashi, K. Oritani, T. Funahashi, Y. Tomiyama, Y. Matsuzawa, P.W. Kincade, J. Immunol. 171, 5091–5099 (2003)

    PubMed  CAS  Google Scholar 

  195. A.M. Wolf, D. Wolf, H. Rumpold, B. Enrich, H. Tilg, Biochem. Biophys. Res. Commun. 323, 630–635 (2004)

    Article  PubMed  CAS  Google Scholar 

  196. M.C. Wulster-Radcliffe, K.M. Ajuwon, J. Wang, J.A. Christian, M.E. Spurlock, Biochem. Biophys. Res. Commun. 316, 924–929 (2004)

    Article  PubMed  CAS  Google Scholar 

  197. M. Neumeier, J. Weigert, A. Schaffler, G. Wehrwein, U. Muller-Ladner, J. Scholmerich, C. Wrede, C. Buechler, J. Leukoc. Biol. 79, 803–808 (2006)

    Article  PubMed  CAS  Google Scholar 

  198. K.M. Ajuwon, M.E. Spurlock, Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R1220–R1225 (2005)

    PubMed  CAS  Google Scholar 

  199. C. Kobashi, M. Urakaze, M. Kishida, E. Kibayashi, H. Kobayashi, S. Kihara, T. Funahashi, M. Takata, R. Temaru, A. Sato, K. Yamazaki, N. Nakamura, M. Kobayashi, Circ. Res. 97, 1245–1252 (2005)

    Article  PubMed  CAS  Google Scholar 

  200. H. Tilg, A.R. Moschen, Nat. Rev. Immunol. 6, 772–783 (2006)

    Article  PubMed  CAS  Google Scholar 

  201. C. Tsatsanis, V. Zacharioudaki, A. Androulidaki, E. Dermitzaki, I. Charalampopoulos, V. Minas, A. Gravanis, A.N. Margioris, Biochem. Biophys. Res. Commun. 335, 1254–1263 (2005)

    Article  PubMed  CAS  Google Scholar 

  202. K. Ebina, A. Fukuhara, W. Ando, M. Hirao, T. Koga, K. Oshima, M. Matsuda, K. Maeda, T. Nakamura, T. Ochi, I. Shimomura, H. Yoshikawa, J. Hashimoto, Clin. Rheumatol. 28, 445–451 (2009)

    Article  PubMed  Google Scholar 

  203. L. Senolt, K. Pavelka, D. Housa, M. Haluzik, Cytokine 35, 247–252 (2006)

    Article  PubMed  CAS  Google Scholar 

  204. A. Schaffler, A. Ehling, E. Neumann, H. Herfarth, I. Tarner, J. Scholmerich, U. Muller-Ladner, S. Gay, JAMA 290, 1709–1710 (2003)

    Article  PubMed  Google Scholar 

  205. A. Ehling, A. Schaffler, H. Herfarth, I.H. Tarner, S. Anders, O. Distler, G. Paul, J. Distler, S. Gay, J. Scholmerich, E. Neumann, U. Muller-Ladner, J. Immunol. 176, 4468–4478 (2006)

    PubMed  CAS  Google Scholar 

  206. K. Kitahara, N. Kusunoki, T. Kakiuchi, T. Suguro, S. Kawai, Biochem. Biophys. Res. Commun. 378, 218–223 (2009)

    Article  PubMed  CAS  Google Scholar 

  207. T. Nakamura, K. Tokunaga, I. Shimomura, M. Nishida, S. Yoshida, K. Kotani, A.H. Islam, Y. Keno, T. Kobatake, Y. Nagai, Atherosclerosis 107, 239–246 (1994)

    Article  PubMed  CAS  Google Scholar 

  208. N. Ouchi, S. Kihara, Y. Arita, K. Maeda, H. Kuriyama, Y. Okamoto, K. Hotta, M. Nishida, M. Takahashi, T. Nakamura, S. Yamashita, T. Funahashi, Y. Matsuzawa, Circulation 100, 2473–2476 (1999)

    PubMed  CAS  Google Scholar 

  209. H. Kobayashi, N. Ouchi, S. Kihara, K. Walsh, M. Kumada, Y. Abe, T. Funahashi, Y. Matsuzawa, Circ. Res. 94, e27–e31 (2004)

    Article  PubMed  CAS  Google Scholar 

  210. F. Otsuka, S. Sugiyama, S. Kojima, H. Maruyoshi, T. Funahashi, K. Matsui, T. Sakamoto, M. Yoshimura, K. Kimura, S. Umemura, H. Ogawa, J. Am. Coll. Cardiol. 48, 1155–1162 (2006)

    Article  PubMed  CAS  Google Scholar 

  211. R. Shibata, K. Sato, D.R. Pimentel, Y. Takemura, S. Kihara, K. Ohashi, T. Funahashi, N. Ouchi, K. Walsh, Nat. Med. 11, 1096–1103 (2005)

    Article  PubMed  CAS  Google Scholar 

  212. Y. Ikeda, K. Ohashi, R. Shibata, D.R. Pimentel, S. Kihara, N. Ouchi, K. Walsh, FEBS. Lett. 582, 1147–1150 (2008)

    Article  PubMed  CAS  Google Scholar 

  213. N. Sattar, G. Wannamethee, N. Sarwar, J. Tchernova, L. Cherry, A.M. Wallace, J. Danesh, P.H. Whincup, Circulation 114, 623–629 (2006)

    Article  PubMed  CAS  Google Scholar 

  214. R.S. Lindsay, H.E. Resnick, J. Zhu, M.L. Tun, B.V. Howard, Y. Zhang, J. Yeh, L.G. Best, Arterioscler. Thromb. Vasc. Biol. 25, e15–e16 (2005)

    Article  PubMed  CAS  Google Scholar 

  215. T. Pischon, J.K. Pai, J.E. Manson, F.B. Hu, K.M. Rexrode, D. Hunter, E.B. Rimm, Obesity (Silver Spring) 15, 2051–2060 (2007)

    Article  CAS  Google Scholar 

  216. Y. Okamoto, Y. Arita, M. Nishida, M. Muraguchi, N. Ouchi, M. Takahashi, T. Igura, Y. Inui, S. Kihara, T. Nakamura, S. Yamashita, J. Miyagawa, T. Funahashi, Y. Matsuzawa, Horm. Metab. Res. 32, 47–50 (2000)

    Article  PubMed  CAS  Google Scholar 

  217. N. Ouchi, S. Kihara, Y. Arita, M. Nishida, A. Matsuyama, Y. Okamoto, M. Ishigami, H. Kuriyama, K. Kishida, H. Nishizawa, K. Hotta, M. Muraguchi, Y. Ohmoto, S. Yamashita, T. Funahashi, Y. Matsuzawa, Circulation 103, 1057–1063 (2001)

    PubMed  CAS  Google Scholar 

  218. K. Kobayashi, T. Inoguchi, N. Sonoda, N. Sekiguchi, H. Nawata, Biochem. Biophys. Res. Commun. 335, 66–70 (2005)

    Article  PubMed  CAS  Google Scholar 

  219. H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, M.J. Quon, J. Biol. Chem. 278, 45021–45026 (2003)

    Article  PubMed  CAS  Google Scholar 

  220. S. Bacci, C. Menzaghi, T. Ercolino, X. Ma, A. Rauseo, L. Salvemini, C. Vigna, R. Fanelli, U. Di Mario, A. Doria, V. Trischitta, Diabetes Care 27, 2015–2020 (2004)

    Article  PubMed  CAS  Google Scholar 

  221. G. Hoefle, A. Muendlein, C.H. Saely, L. Risch, P. Rein, L. Koch, F. Schmid, S. Aczel, T. Marte, P. Langer, H. Drexel, Thromb. Haemost. 97, 451–457 (2007)

    PubMed  CAS  Google Scholar 

  222. M. Qin, Z. Zeng, J. Zheng, P.K. Shah, S.M. Schwartz, L.D. Adams, B.G. Sharifi, Arterioscler. Thromb. Vasc. Biol. 23, 425–433 (2003)

    Article  PubMed  CAS  Google Scholar 

  223. T. Takeuchi, Y. Adachi, Y. Ohtsuki, M. Furihata, Med. Mol. Morphol. 40, 115–120 (2007)

    Article  PubMed  CAS  Google Scholar 

  224. T. Takahashi, S. Saegusa, H. Sumino, T. Nakahashi, K. Iwai, S. Morimoto, T. Kanda, J. Int. Med. Res. 33, 207–214 (2005)

    PubMed  CAS  Google Scholar 

  225. R. Shibata, N. Ouchi, M. Ito, S. Kihara, I. Shiojima, D.R. Pimentel, M. Kumada, K. Sato, S. Schiekofer, K. Ohashi, T. Funahashi, W.S. Colucci, K. Walsh, Nat. Med. 10, 1384–1389 (2004)

    Article  PubMed  CAS  Google Scholar 

  226. O.A. MacDougald, S. Mandrup, Trends Endocrinol. Metab. 13, 5–11 (2002)

    Article  PubMed  CAS  Google Scholar 

  227. W.S. Yang, W.J. Lee, T. Funahashi, S. Tanaka, Y. Matsuzawa, C.L. Chao, C.L. Chen, T.Y. Tai, L.M. Chuang, J. Clin. Endocrinol. Metab. 86, 3815–3819 (2001)

    Article  PubMed  CAS  Google Scholar 

  228. M.S. Rasmussen, A.S. Lihn, S.B. Pedersen, J.M. Bruun, M. Rasmussen, B. Richelsen, Obesity (Silver Spring) 14, 28–35 (2006)

    Article  CAS  Google Scholar 

  229. K. Hotta, T. Funahashi, Y. Arita, M. Takahashi, M. Matsuda, Y. Okamoto, H. Iwahashi, H. Kuriyama, N. Ouchi, K. Maeda, M. Nishida, S. Kihara, N. Sakai, T. Nakajima, K. Hasegawa, M. Muraguchi, Y. Ohmoto, T. Nakamura, S. Yamashita, T. Hanafusa, Y. Matsuzawa, Arterioscler. Thromb. Vasc. Biol. 20, 1595–1599 (2000)

    PubMed  CAS  Google Scholar 

  230. J. Spranger, A. Kroke, M. Mohlig, M.M. Bergmann, M. Ristow, H. Boeing, A.F. Pfeiffer, Lancet 361, 226–228 (2003)

    Article  PubMed  CAS  Google Scholar 

  231. K. Hara, M. Horikoshi, T. Yamauchi, H. Yago, O. Miyazaki, H. Ebinuma, Y. Imai, R. Nagai, T. Kadowaki, Diabetes Care 29, 1357–1362 (2006)

    Article  PubMed  CAS  Google Scholar 

  232. H. Waki, T. Yamauchi, J. Kamon, Y. Ito, S. Uchida, S. Kita, K. Hara, Y. Hada, F. Vasseur, P. Froguel, S. Kimura, R. Nagai, T. Kadowaki, J. Biol. Chem. 278, 40352–40363 (2003)

    Article  PubMed  CAS  Google Scholar 

  233. T. Yamauchi, J. Kamon, H. Waki, Y. Imai, N. Shimozawa, K. Hioki, S. Uchida, Y. Ito, K. Takakuwa, J. Matsui, M. Takata, K. Eto, Y. Terauchi, K. Komeda, M. Tsunoda, K. Murakami, Y. Ohnishi, T. Naitoh, K. Yamamura, Y. Ueyama, P. Froguel, S. Kimura, R. Nagai, T. Kadowaki, J. Biol. Chem. 278, 2461–2468 (2003)

    Article  PubMed  CAS  Google Scholar 

  234. X. Hu, M. She, H. Hou, Q. Li, Q. Shen, Y. Luo, W. Yin, Acta Biochim. Biophys. Sin. 39, 131–136 (2007)

    Article  PubMed  CAS  Google Scholar 

  235. F. Vasseur, D. Meyre, P. Froguel, Expert Rev. Mol. Med. 8, 1–12 (2006)

    Article  PubMed  Google Scholar 

  236. S.M. Ruchat, R.J. Loos, T. Rankinen, M.C. Vohl, S.J. Weisnagel, J.P. Despres, C. Bouchard, L. Perusse, Diabet. Med. 25, 400–406 (2008)

    Article  PubMed  CAS  Google Scholar 

  237. A. Petrone, S. Zavarella, A. Caiazzo, G. Leto, M. Spoletini, S. Potenziani, J. Osborn, A. Vania, R. Buzzetti, Obesity (Silver Spring) 14, 1498–1504 (2006)

    Article  CAS  Google Scholar 

  238. D. Canoy, R. Luben, A. Welch, S. Bingham, N. Wareham, N. Day, K.T. Khaw, J. Hypertens. 22, 2067–2074 (2004)

    Article  PubMed  CAS  Google Scholar 

  239. J. Ran, T. Hirano, T. Fukui, K. Saito, H. Kageyama, K. Okada, M. Adachi, Metabolism 55, 478–488 (2006)

    Article  PubMed  CAS  Google Scholar 

  240. M. Tanida, J. Shen, Y. Horii, M. Matsuda, S. Kihara, T. Funahashi, I. Shimomura, H. Sawai, Y. Fukuda, Y. Matsuzawa, K. Nagai, Exp. Biol. Med. (Maywood) 232, 390–397 (2007)

    CAS  Google Scholar 

  241. Z.V. Wang, P.E. Scherer, Hypertension 51, 8–14 (2008)

    Article  PubMed  CAS  Google Scholar 

  242. L.R. Kurukulasuriya, S. Stas, G. Lastra, C. Manrique, J.R. Sowers, Endocrinol. Metab. Clin. North Am. 37, 647–662, ix (2008)

    Google Scholar 

  243. J. Hulthe, L.M. Hulten, B. Fagerberg, Metabolism 52, 1612–1614 (2003)

    Article  PubMed  CAS  Google Scholar 

  244. M. von Eynatten, A. Hamann, D. Twardella, P.P. Nawroth, H. Brenner, D. Rothenbacher, Clin. Chem. 52, 853–859 (2006)

    Article  CAS  Google Scholar 

  245. T. Okada, E. Saito, Y. Kuromori, M. Miyashita, F. Iwata, M. Hara, K. Harada, Atherosclerosis 188, 179–183 (2006)

    Article  PubMed  CAS  Google Scholar 

  246. K. Kantartzis, K. Rittig, B. Balletshofer, J. Machann, F. Schick, K. Porubska, A. Fritsche, H.U. Haring, N. Stefan, Clin. Chem. 52, 1934–1942 (2006)

    Article  PubMed  CAS  Google Scholar 

  247. B. Verges, J.M. Petit, L. Duvillard, G. Dautin, E. Florentin, F. Galland, P. Gambert, Arterioscler. Thromb. Vasc. Biol. 26, 1364–1369 (2006)

    Article  PubMed  CAS  Google Scholar 

  248. Y. Okamoto, S. Kihara, T. Funahashi, Y. Matsuzawa, P. Libby, Clin. Sci. (Lond) 110, 267–278 (2006)

    Article  CAS  Google Scholar 

  249. Y. Seino, H. Hirose, I. Saito, H. Itoh, Metabolism 58, 355–360 (2009)

    Article  PubMed  CAS  Google Scholar 

  250. R. Dolezalova, Z. Lacinova, M. Dolinkova, P. Kleiblova, D. Haluzikova, D. Housa, H. Papezova, M. Haluzik, Clin. Endocrinol. (Oxf) 67, 674–678 (2007)

    Article  CAS  Google Scholar 

  251. M.L. Delporte, S.M. Brichard, M.P. Hermans, C. Beguin, M. Lambert, Clin. Endocrinol. (Oxf) 58, 22–29 (2003)

    Article  CAS  Google Scholar 

  252. N. Pannacciulli, R. Vettor, G. Milan, M. Granzotto, A. Catucci, G. Federspil, P. De Giacomo, R. Giorgino, G. De Pergola, J. Clin. Endocrinol. Metab. 88, 1748–1752 (2003)

    Article  PubMed  CAS  Google Scholar 

  253. D. Modan-Moses, D. Stein, C. Pariente, A. Yaroslavsky, A. Ram, M. Faigin, R. Loewenthal, E. Yissachar, R. Hemi, H. Kanety, J. Clin. Endocrinol. Metab. 92, 1843–1847 (2007)

    Article  PubMed  CAS  Google Scholar 

  254. I. Dostalova, K. Smitka, H. Papezova, H. Kvasnickova, J. Nedvidkova, Physiol. Res. 56, 587–594 (2007)

    PubMed  CAS  Google Scholar 

  255. T. Tagami, N. Satoh, T. Usui, K. Yamada, A. Shimatsu, H. Kuzuya, J. Clin. Endocrinol. Metab. 89, 1833–1837 (2004)

    Article  PubMed  CAS  Google Scholar 

  256. T. Pischon, U. Nothlings, H. Boeing, Proc. Nutr. Soc. 67, 128–145 (2008)

    Article  PubMed  Google Scholar 

  257. E. Brakenhielm, N. Veitonmaki, R. Cao, S. Kihara, Y. Matsuzawa, B. Zhivotovsky, T. Funahashi, Y. Cao, Proc. Natl. Acad. Sci. USA 101, 2476–2481 (2004)

    Article  PubMed  CAS  Google Scholar 

  258. A. Korner, K. Pazaitou-Panayiotou, T. Kelesidis, I. Kelesidis, C.J. Williams, A. Kaprara, J. Bullen, A. Neuwirth, S. Tseleni, N. Mitsiades, W. Kiess, C.S. Mantzoros, J. Clin. Endocrinol. Metab. 92, 1041–1048 (2007)

    Article  PubMed  CAS  Google Scholar 

  259. Y. Wang, J.B. Lam, K.S. Lam, J. Liu, M.C. Lam, R.L. Hoo, D. Wu, G.J. Cooper, A. Xu, Cancer Res. 66, 11462–11470 (2006)

    Article  PubMed  CAS  Google Scholar 

  260. M.E. Grossmann, K.J. Nkhata, N.K. Mizuno, A. Ray, M.P. Cleary, Br. J. Cancer 98, 370–379 (2008)

    Article  PubMed  CAS  Google Scholar 

  261. V.G. Kaklamani, M. Sadim, A. Hsi, K. Offit, C. Oddoux, H. Ostrer, H. Ahsan, B. Pasche, C. Mantzoros, Cancer Res. 68, 3178–3184 (2008)

    Article  PubMed  CAS  Google Scholar 

  262. A.E. Cust, R. Kaaks, C. Friedenreich, F. Bonnet, M. Laville, A. Lukanova, S. Rinaldi, L. Dossus, N. Slimani, E. Lundin, A. Tjonneland, A. Olsen, K. Overvad, F. Clavel-Chapelon, S. Mesrine, V. Joulin, J. Linseisen, S. Rohrmann, T. Pischon, H. Boeing, D. Trichopoulos, A. Trichopoulou, V. Benetou, D. Palli, F. Berrino, R. Tumino, C. Sacerdote, A. Mattiello, J.R. Quiros, M.A. Mendez, M.J. Sanchez, N. Larranaga, M.J. Tormo, E. Ardanaz, H.B. Bueno-de-Mesquita, P.H. Peeters, C.H. van Gils, K.T. Khaw, S. Bingham, N. Allen, T. Key, M. Jenab, E. Riboli, J. Clin. Endocrinol. Metab. 92, 255–263 (2007)

    Article  PubMed  CAS  Google Scholar 

  263. T. Mistry, J.E. Digby, K.M. Desai, H.S. Randeva, Eur. Urol. 52, 46–53 (2007)

    Article  PubMed  CAS  Google Scholar 

  264. S. Goktas, M.I. Yilmaz, K. Caglar, A. Sonmez, S. Kilic, S. Bedir, Urology 65, 1168–1172 (2005)

    Article  PubMed  Google Scholar 

  265. D.J. Sher, W.K. Oh, S. Jacobus, M.M. Regan, G.S. Lee, C. Mantzoros, Prostate 68, 1592–1598 (2008)

    Article  PubMed  CAS  Google Scholar 

  266. J.D. Bub, T. Miyazaki, Y. Iwamoto, Biochem. Biophys. Res. Commun. 340, 1158–1166 (2006)

    Article  PubMed  CAS  Google Scholar 

  267. T. Nishihara, M. Baba, M. Matsuda, M. Inoue, Y. Nishizawa, A. Fukuhara, H. Araki, S. Kihara, T. Funahashi, S. Tamura, N. Hayashi, H. Iishi, I. Shimomura, World J. Gastroenterol. 14, 6473–6480 (2008)

    Article  PubMed  CAS  Google Scholar 

  268. V.G. Kaklamani, K.B. Wisinski, M. Sadim, C. Gulden, A. Do, K. Offit, J.A. Baron, H. Ahsan, C. Mantzoros, B. Pasche, JAMA 300, 1523–1531 (2008)

    Article  PubMed  CAS  Google Scholar 

  269. L.G. Carvajal-Carmona, S. Spain, D. Kerr, R. Houlston, J.B. Cazier, I. Tomlinson, CORGI Consortium, Hum. Mol. Genet. 18, 1889–1892 (2009)

    Article  PubMed  CAS  Google Scholar 

  270. S. Shetty, C.M. Kusminski, P.E. Scherer, Trends Pharmacol. Sci. 30, 234–239 (2009)

    Article  PubMed  CAS  Google Scholar 

  271. N.L. Brooks, K.S. Moore, R.D. Clark, M.T. Perfetti, C.M. Trent, T.P. Combs, Diabetes Obes. Metab. 9, 246–258 (2007)

    Article  PubMed  CAS  Google Scholar 

  272. F. Montecucco, F. Mach, Diabetes Obes. Metab. 11, 445–454 (2009)

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We would like to thank Guylaine Lessard for the graphic work and the Natural Sciences and Engineering Research Council of Canada for financial support in the form of a scholarship granted to KBG. Sherbrooke AAC contribution no. 1026.

Author information

Authors and Affiliations

  1. Département de biologie, Université de Sherbrooke, Sherbrooke, QC, Canada

    Karine Brochu-Gaudreau & Richard Blouin

  2. Dairy & Swine R & D Centre, Agriculture & Agri-Food Canada, Sherbrooke, QC, Canada

    Karine Brochu-Gaudreau & Marie-France Palin

  3. Research Institute for the Biology of Farm Animals, Dummerstorf, Germany

    Charlotte Rehfeldt

  4. Department of Animal Science, McGill University, Ste-Anne-de-Bellevue, QC, Canada

    V. Bordignon

  5. Centre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, QC, Canada

    Bruce D. Murphy

Authors
  1. Karine Brochu-Gaudreau
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charlotte Rehfeldt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard Blouin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Bordignon
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bruce D. Murphy
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marie-France Palin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marie-France Palin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brochu-Gaudreau, K., Rehfeldt, C., Blouin, R. et al. Adiponectin action from head to toe. Endocr 37, 11–32 (2010). https://doi.org/10.1007/s12020-009-9278-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-009-9278-8

Keywords

Search

Navigation