Abstract
Graves’ disease (GD) is a common autoimmune disorder with a genetic predisposition. The cytokine interleukin-10 (IL-10) has a central role in mediating inflammation, which may affect the outcome of the patients with GD. To elucidate the impact of IL-10 gene polymorphisms, we performed a two-stage case–control association study of five single-nucleotide polymorphisms (SNPs) within the IL-10 gene as well as a meta-analysis of two SNP’s rs1800896 and rs1800872 covering three previous studies from Iran, Taiwan, and the United Kingdom. The five SNPs were genotyped by SNPstream Genotyping and Taqman PCR. There was a significant increase of G allele of rs1800896 in the two cohorts (P allele = 2.6 × 10−4 and 0.0082 for cohort Shanghai and Xiamen, respectively) compared with the controls. The meta-analysis showed the risk-increasing effects for the G allele of rs1800896 in GD (OR = 1.88; P < 0.00001). The allele and haplotype analysis results suggested that the polymorphisms of IL-10 were associated with GD susceptibility in the Chinese population.
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Acknowledgments
This study would not have been possible without the participation of the patients and healthy volunteers. The study was partly supported by Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Public Health (No. 1994DP131044) and National Natural Science Foundation of China (No. 81070670).
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Nan Liu and Hao Lu contributed equally to this study.
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Liu, N., Lu, H., Tao, F. et al. An association of interleukin-10 gene polymorphisms with Graves’ disease in two Chinese populations. Endocrine 40, 90–94 (2011). https://doi.org/10.1007/s12020-011-9444-7
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DOI: https://doi.org/10.1007/s12020-011-9444-7