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A challenge for the future: aging and HIV infection

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Abstract

Older individuals (≥50 years of age) are increasingly becoming a new at-risk group for HIV-1 infection and, together with those surviving longer due to the introduction of anti-retroviral therapy (ART), it is predicted that more than half of all HIV-1-infected individuals in the United States will be greater than 50 years of age in the year 2015. Older individuals diagnosed with HIV-1 are prone to faster disease progression and reduced T-cell reconstitution despite successful virologic control with anti-retroviral therapy (ART). There is also growing evidence that the T-cell compartment in HIV-1+ adults displays an aged phenotype, and HIV-1-infected individuals are increasingly diagnosed with clinical conditions more commonly seen in older uninfected persons. As aging in the absence of HIV infection is associated with alterations in T-cell function and immunosenescence, the combined impact of both HIV-1 infection and aging may provide an explanation for poorer clinical outcomes observed in older HIV-1-infected individuals. Thus, the development of novel therapeutics to stimulate immune function and delay immunosenescence is critical and would be beneficial to both the elderly and HIV-1-infected individuals.

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Acknowledgments

We wish to thank all the study participants, including those from the Multi-Center AIDS Cohort Study (MACS), for their contribution to this work. We also thank Dr. Rita Effros for many enlightening discussions on this subject matter and Dr. Catherine Brennan for careful reading of this manuscript and constructive criticism of the work. The research described in this review was supported by NIAID Grant 5RO1-AI-058845 and NIA Grant 1RO1-AG-030327 awarded to B.D. Jamieson. T.M. Rickabaugh was also supported by the National Institutes of Health under Ruth L. Kirschstein National Research Service Award, 5 T32 CA009120, from the National Cancer Institute.

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    Tammy M. Rickabaugh & Beth D. Jamieson

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Correspondence to Beth D. Jamieson.

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Rickabaugh, T.M., Jamieson, B.D. A challenge for the future: aging and HIV infection. Immunol Res 48, 59–71 (2010). https://doi.org/10.1007/s12026-010-8167-9

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