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Adult Langerhans cell histiocytosis and sclerosing cholangitis: a case report and review of the literature

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Abstract

Background/aims

Sclerosing cholangitis is a rare complication of Langerhans cell histiocytosis in children which can result in liver failure. This combination is even rarer in adults.

Case report

We report a 65-year-old female who developed sclerosing cholangitis 4 years after the diagnosis of Langerhans cell histiocytosis.

Conclusion

Sclerosing cholangitis caused by Langerhans cell histiocytosis is a rare condition in the adult population, but it has a high mortality. There is no definitive therapy other than liver transplantation. The long-term efficacy of liver transplantation remains unknown.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, Istanbul University Cerrahpasa Medical Faculty, 34098, Aksaray, Istanbul, Turkey

    Ibrahim Hatemi, Birol Baysal, Hakan Senturk & Gulsen Ozbay

  2. Department of Pathology, Istanbul Education and Research Hospital, Abdurrahman Nafiz Gurman Caddesi Kocamustafapasa Fatih, Istanbul, Turkey

    Kemal Behzatoglu & Erol Rustu Bozkurt

Authors
  1. Ibrahim Hatemi
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  2. Birol Baysal
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  3. Hakan Senturk
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  4. Kemal Behzatoglu
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  5. Erol Rustu Bozkurt
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  6. Gulsen Ozbay
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Corresponding author

Correspondence to Ibrahim Hatemi.

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Hatemi, I., Baysal, B., Senturk, H. et al. Adult Langerhans cell histiocytosis and sclerosing cholangitis: a case report and review of the literature. Hepatol Int 4, 653–658 (2010). https://doi.org/10.1007/s12072-010-9205-3

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  • DOI: https://doi.org/10.1007/s12072-010-9205-3

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