Abstract
Glandular odontogenic cyst (GOC) is an uncommon jaw bone cyst of odontogenic origin described in 1987 by Gardner et al. It is a cyst having an unpredictable and potentially aggressive behaviour. It also has the propensity to grow to a large size and tendency to recur with only 111 cases having been reported thus far. The first case occurred in a 42-year-old female and presented as a localized swelling extending from 19 to 29 regions. There was a history of traumatic injury at the site. There was evidence of bicortical expansion and radiographs revealed a multilocular radiolucency. The second case occurred in a 21-year-old male, as a large swelling in the mandible and radiograph revealed radiolucency in the region. On histopathological examination, these lesions were diagnosed as GOC. It was concluded that, two cases submitted by us correlate with the existing literature that GOC’s affect more commonly in the middle age group, having predilection for mandible and that trauma could be a precipitating factor for its occurrence. The increased recurrence rates can be due to its intrinsic biological behavior, multilocularity of the cyst, and incomplete removal of the lining following conservative treatment.
References
Gardner DG, Kessler HP, Morency R, Schaner DL. The glandular odontogenic cyst: an apparent entity. J Oral Pathol. 1988;17:359–66. doi:10.1111/j.1600-0714.1988.tb01298.x.
Padayachee A, Van Wyk CW. Two cystic lesions with features of both the botryoid odontogenic cyst and the central mucoepidermoid tumour: sialo-odontogenic cyst? J Oral Pathol. 1987;16:499–504. doi:10.1111/j.1600-0714.1987.tb00680.x.
Kramer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumors. 2nd ed. Berlin: Springer; 1992.
Kaplan I, Anavi Y, Hirshberg A. Glandular odontogenic cyst: a challenge in diagnosis and treatment. Oral Dis. 2008;14:575–81. doi:10.1111/j.1601-0825.2007.01428.x.
Magnussson B, Goransson L, Odesjo B, Grondahl K, Hirsch JM. Glandular odontogenic cyst: report of seven cases. Dentomaxillofac Radiol. 1997;26:26. doi:10.1038/sj.dmfr.4600205.
Junior OF, Azevedo LR, Sant’ana E, et al. Case report and review of literature. Quintessence Int. 2004;35:385.
Gardner GD, Morency R. The glandular odontogenic cyst, a rare lesion that tends to recur. J Can Dent Assoc. 1993;59:929.
Hussain K, Edmondson HD, Browne RM. Glandular odontogenic cysts: diagnosis and treatment—Review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(5):593–602. doi:10.1016/S1079-2104(05)80101-5.
Patron M, Colmero C, Larrauri J. Glandular odontogenic cyst: clinicopathologic analysis of three cases. Oral Surg Oral Med Oral Pathol. 1991;72:71–4. doi:10.1016/0030-4220(91)90192-F.
Toida M, Nakashima E, Okumura Y, Tatematsu N. Glandular odontogenic cyst: a case report and literature review. J Oral Maxillofac Surg. 1994;52:1312–6. doi:10.1016/0278-2391(94)90054-X.
Tran PT, Cunningham CJ, Baughman RA. Glandular odontogenic cyst. J Endod. 2004;30:182. doi:10.1097/00004770-200403000-00014.
Manor R, Anavi Y, Kaplan I, Calderon S. Radiological features of glandular odontogenic cyst. Dentomaxillofac Radiol. 2003;32:73–9. doi:10.1259/dmfr/22912856.
Noffke C, Raubenheimer EJ. The glandular odontogenic cyst: clinical and Radiological features; review of literature and report of nine cases. Dentomaxillofac Radiol. 2002;31:333. doi:10.1038/sj.dmfr.4600730.
Van Heerden WFP, Raubenheimer EJ, Turner MJ. Glandular odontogenic cyst. Head Neck. 1992;14:316–20. doi:10.1002/hed.2880140412.
Shen J, Fan M, Chen X, Wang S, Wang L, Li Y. Glandular odontogenic cyst in China: report of 12 cases and immunohistochemical study. J Oral Pathol Med. 2006;35:175–82. doi:10.1111/j.1600-0714.2006.00389.x.
Chavez JA, Richter KJ. Glandular odontogenic cyst of the mandible: review. J Oral Maxillofac Surg. 1999;57(4):461–4. doi:10.1016/S0278-2391(99)90291-4.
Takeda Y. Glandular odontogenic cyst mimicking a lateral periodontal cyst: a case report. Int J Oral Maxillofac Surg. 1994;23:96–7. doi:10.1016/S0901-5027(05)80600-9.
Regezi JA. Odontogenic cysts, odontogenic tumors, fibrosseous and giant cell lesions of the jaws. Mod Pathol. 2002;15:33. doi:10.1038/modpathol.3880527.
Geist J, Gordon S, Wesley R. Oral pathology quiz: an unusual pericoronal cyst. J Mich Dent Assoc. 2003;85:40.
Ide F, Shimoyama T, Horie N. Glandular odontogenic cyst with hyaline bodies: an unusual dentigerous presentation. J Oral Pathol Med. 1996;25:401. doi:10.1111/j.1600-0714.1996.tb00286.x.
Waldron CA, Koh ML. Central mucoepidermoid carcinoma of the jaws: a report of four cases with analysis of the literature and discussion of the relationship to mucoepidermoid, sialodontogenic, and glandular odontogenic cysts. J Oral Maxillofac Surg. 1990;48:871–7. doi:10.1016/0278-2391(90)90349-7.
Velez I. Glandular odontogenic cyst. Report of two cases and review of the literature. N Y State Dent J. 2006;72(1):44–5.
Sittitavornwong S, Koehler JR, Said-Al-Naief N. Glandular odontogenic cyst of the anterior maxilla: case report and review of the literature. J Oral Maxillofac Surg. 2006;64:740–5. doi:10.1016/j.joms.2005.12.024.
Kasaboglu O, Basal Z, Usubutun A. Glandular odontogenic cyst presenting as a dentigerous cyst: a case report. J Oral Maxillofac Surg. 2006;64:731–3. doi:10.1016/j.joms.2005.12.020.
Ramer M, Montazem A, Lane SL, Lumerman H. Glandular odontogenic cyst. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol. 1997;84:54–7.
Economopoulou P, Patrikiou A. Glandular odontogenic cyst of the maxilla: report of case. J Oral Maxillofac Surg. 1995;53(7):834–7. doi:10.1016/0278-2391(95)90345-3.
Koppang HS, Johannessen S, Haugen LIC, Haanaes HR, Solheim T, Donath K. Glandular odontogenic cyst (sialo-odontogenic cyst): a report of two cases and literature review of 45 previously reported cases. J Oral Pathol Med. 1998;27:455–62.
Ficarra G, Chou L, Panzoni E. Glandular odontogenic cyst (sialo-odontogenic cyst). Int J Oral Maxillofac Surg. 1990;19:331–3. doi:10.1016/S0901-5027(05)80074-8.
Bhatt V, Monaghan A, Brown AM, Rippin JW. Does the glandular odontogenic cyst require aggressive management? Oral Surg Oral Med Oral Pathol. 2001;92:249–51.
Takeda Y, Oikawa Y, Furuya I, Satoh M, Yamamoto H. Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts. J Oral Sci. 2005;47(2):77–81. doi:10.2334/josnusd.47.77.
Slabbert H, Shear M, Altini M. Vacoulated cells and mucous metaplasia in the epithelial cell lining of residual and radicular cysts. J Oral Pathol Med. 1995;24:309–12. doi:10.1111/j.1600-0714.1995.tb01190.x.
De Soussa SO, Cabexas NT, De Oliveira PT, De Araujo VC. Glandular odontogenic cyst report of a case with cytokeratin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83:478–83. doi:10.1016/S1079-2104(97)90149-9.
Semba I, Kitano M, Mimura T, Sonoda S, Miyawaki A. Case report. Glandular odontogenic cyst: analysis of cytokeratin expression and clinicopathological features. J Oral Pathol Med. 1994;23:377–82. doi:10.1111/j.1600-0714.1994.tb00079.x.
Shear M, Pindborg JJ. Microscopic features of the lateral periodontal cyst. Scand J Dent Res. 1975;83:103.
Gurol M, Burkes EJ Jr, Jacoway J. Botryoid odontogenic cyst. Analysis of 33 cases. J Periodontol. 1995;66:1069.
Kaplan I, Anavi Y, Manor R, Sulkes J, Calderon S. The use of molecular markers as an aid in the diagnosis of glandular odontogenic cyst. Oral Oncol. 2005;41:895–902. doi:10.1016/j.oraloncology.2005.04.015.
Pires FR, Chen SY, Perez DEC, Almedia OP, Kowalski LP. Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst. Oral Oncol. 2004;40:545–51. doi:10.1016/j.oraloncology.2003.11.007.
Tosios KI, Kakarantza-Angelopoulou E, Kapranos N. Immunohistochemical study of Bcl2 protein, Ki 67 antigen and p53 protein in epithelium of glandular odontogenic cysts and dentigerous cysts. J Oral Pathol Med. 2000;29:139–44. doi:10.1034/j.1600-0714.2000.290306.x.
Kaplan I, Gal G, Anavi Y, Manor R, Calderon S. Glandular odontogenic cyst: treatment and recurrence. J Oral Maxillofac Surg. 2005;63:435–41. doi:10.1016/j.joms.2004.08.007.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Krishnamurthy, A., Sherlin, H.J., Ramalingam, K. et al. Glandular Odontogenic Cyst: Report of Two Cases and Review of Literature. Head and Neck Pathol 3, 153–158 (2009). https://doi.org/10.1007/s12105-009-0117-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12105-009-0117-2